Tag : Wnt

Gastroenterology

Activation of Wnt signaling by amniotic fluid stem cell-derived extracellular vesicles attenuates intestinal injury in experimental necrotizing enterocolitis

Newsemia
Activation of Wnt signaling by amniotic fluid stem cell-derived extracellular vesicles attenuates intestinal injury in experimental necrotizing enterocolitis Source link...
Gastroenterology

In Colorectal Cancer Cells With Mutant KRAS, SLC25A22-Mediated Glutaminolysis Reduces DNA Demethylation to Increase WNT Signaling, Stemness, and Drug Resistance

Newsemia
Mutant KRAS promotes glutaminolysis, a process that uses steps from the tricarboxylic cycle to convert glutamine to α-ketoglutarate and other molecules, via glutaminase and solute...
Pharma / Biotech

A Small-Molecule Inhibitor of the Wnt Pathway, Lorecivivint (SM04690), as a Potential Disease-Modifying Agent for the Treatment of Degenerative Disc Disease.

Newsemia
A Small-Molecule Inhibitor of the Wnt Pathway, Lorecivivint (SM04690), as a Potential Disease-Modifying Agent for the Treatment of Degenerative Disc Disease. Spine J. 2020 May...
Cardiology

Exogenous spermine attenuates myocardial fibrosis in diabetic cardiomyopathy by inhibiting endoplasmic reticulum stress and the canonical Wnt signaling pathway.

Newsemia
Related Articles Exogenous spermine attenuates myocardial fibrosis in diabetic cardiomyopathy by inhibiting endoplasmic reticulum stress and the canonical Wnt signaling pathway. Cell Biol Int. 2020...
Biology

Endosomal Wnt signaling proteins control microtubule nucleation in dendrites

Newsemia
by Alexis T. Weiner, Dylan Y. Seebold, Pedro Torres-Gutierrez, Christin Folker, Rachel D. Swope, Gregory O. Kothe, Jessica G. Stoltz, Madeleine K. Zalenski, Christopher Kozlowski,...
Biology

Glioblastoma cells vampirize WNT from neurons and trigger a JNK/MMP signaling loop that enhances glioblastoma progression and neurodegeneration

Newsemia
by Marta Portela, Varun Venkataramani, Natasha Fahey-Lozano, Esther Seco, Maria Losada-Perez, Frank Winkler, Sergio Casas-Tintó Glioblastoma (GB) is the most lethal brain tumor, and Wingless...
Biology

Dissecting the dynamics of signaling events in the BMP, WNT, and NODAL cascade during self-organized fate patterning in human gastruloids

Newsemia
by Sapna Chhabra, Lizhong Liu, Ryan Goh, Xiangyu Kong, Aryeh Warmflash During gastrulation, the pluripotent epiblast self-organizes into the 3 germ layers—endoderm, mesoderm and ectoderm,...
Biology

Control over single-cell distribution of G1 lengths by WNT governs pluripotency

Newsemia
by Jiwon Jang, Dasol Han, Mahdi Golkaram, Morgane Audouard, Guojing Liu, Daniel Bridges, Stefan Hellander, Alex Chialastri, Siddharth S. Dey, Linda R. Petzold, Kenneth S....
Latest News

Mutations in TFAP2B and previously unimplicated genes of the BMP, Wnt, and Hedgehog pathways in syndromic craniosynostosis

Newsemia
Timberlake, AT; Jin, SC; Nelson-Williams, C; Wu, R; Furey, CG; Islam, B; Haider, S; … Lifton, RP; + view all Timberlake, AT; Jin, SC; Nelson-Williams,...
Latest News

Wnt signaling regulates cytosolic translocation of Connexin 43

Newsemia
Hou, X; Khan, MRA; Turmaine, M; Thrasivoulou, C; Becker, DL; Ahmed, A; (2019) Wnt signaling regulates cytosolic translocation of Connexin 43. American Journal of Physiology...

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