Tag: VEGF

Cardiology

The NO-donor MPC-1011 stimulates angiogenesis and arteriogenesis and improves hindlimb ischemia via a cGMP-dependent pathway involving VEGF and SDF-1α.

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Related Articles The NO-donor MPC-1011 stimulates angiogenesis and arteriogenesis and improves hindlimb ischemia via a cGMP-dependent pathway involving VEGF and SDF-1α. Atherosclerosis. 2020 May 30;304:30-38...
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Study uncovers cause of blood-vessel leakiness in eye diseases

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Scientists have identified a key step in the process that leads to leaky vessels and harmful swelling in eye diseases, according to a new study...
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Study may provide novel targetable mechanisms of therapeutic resistance to anti-VEGF therapies

Newsemia
To establish a molecular signature of this resistance in ovarian cancer, the authors developed preclinical tumor models of adaptive resistance to chronic anti-VEGF treatment. Source...
Gastroenterology

Combination therapy improves survival in patients with hepatocellular carcinoma

Newsemia
Combination therapy with the PD-L1 inhibitor atezolizumab and the VEGF inhibitor bevacizumab significantly improves overall survival and progression-free survival in patients with unresectable hepatocellular carcinoma...
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Drugs used to treat retinal diseases are excreted into human breast milk, study finds

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Certain drugs used to treat retinal diseases are excreted into breast milk, raising possible safety concerns for developing infants, suggests a first-of-its-kind study led by...
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'Eye-in-a-dish' model helps scientists to uncover 'surprising' AMD gene variant

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Researchers have discovered a new genetic variant responsible for blood vessel dysregulation in the development of age-related macular degeneration (AMD). Source link...
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Study shows therapeutic potential of VEGF-A mRNA for regenerative angiogenesis in humans

Newsemia
An international team of researchers from academia and the biopharma industry has published a Phase 1a/b study, showing the therapeutic potential of mRNA encoding for...
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Raised VEGF: High sensitivity and specificity in the diagnosis of POEMS syndrome

Newsemia
Pihan, M; Keddie, S; D’Sa, S; Church, AJ; Yong, KL; Reilly, MM; Lunn, MP; (2018) Raised VEGF: High sensitivity and specificity in the diagnosis of...
Gastroenterology

NCCN updates Clinical Practice Guidelines to include new recommendations for CABOMETYX tablets

Newsemia
Exelixis, Inc. today announced that the National Comprehensive Cancer Network updated its Clinical Practice Guidelines to include new recommendations for CABOMETYX tablets. Source link...
Pharma / Biotech

Involvement of vascular endothelial growth factor (VEGF) and mitogen-activated protein kinases (MAPK) in the mechanism of neuroleptic drugs.

Newsemia
Related Articles Involvement of vascular endothelial growth factor (VEGF) and mitogen-activated protein kinases (MAPK) in the mechanism of neuroleptic drugs. Pharmacol Rep. 2018 Aug 22;70(5):1032-1039...

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