Tag : Upregulation

Cardiology

Proteomic analysis reveals upregulation of ACE2, the putative SARS-CoV-2 receptor in pressure- but not volume-overloaded human hearts.

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Related Articles Proteomic analysis reveals upregulation of ACE2, the putative SARS-CoV-2 receptor in pressure- but not volume-overloaded human hearts. Hypertension. 2020 Sep 24;: Authors: Stegbauer...
Cardiology

Hexokinase II Upregulation Contributes to Asiaticoside-Induced Protection of H9c2 Cardioblasts During Oxygen-Glucose Deprivation/Reoxygenation.

Newsemia
Related Articles Hexokinase II Upregulation Contributes to Asiaticoside-Induced Protection of H9c2 Cardioblasts During Oxygen-Glucose Deprivation/Reoxygenation. J Cardiovasc Pharmacol. 2020 01;75(1):84-90 Authors: Zhang J, Yao M,...
Dermatology

Targeting PHGDH Upregulation Reduces Glutathione Levels and Resensitizes Resistant NRAS-Mutant Melanoma to MAPK Kinase Inhibition

Newsemia
Melanomas frequently harbor activating NRAS mutations leading to activation of MAPK kinase (MEK) and extracellular signal–regulated kinase 1/2 signaling; however, the clinical efficacy of inhibitors...
Cardiology

MCU Up-regulation contributes to myocardial ischemia-reperfusion Injury through calpain/OPA-1-mediated mitochondrial fusion/mitophagy Inhibition.

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Related Articles MCU Up-regulation contributes to myocardial ischemia-reperfusion Injury through calpain/OPA-1-mediated mitochondrial fusion/mitophagy Inhibition. J Cell Mol Med. 2019 11;23(11):7830-7843 Authors: Guan L, Che Z,...
Gastroenterology

Correction: Upregulation of SNX5 predicts poor prognosis and promotes hepatocellular carcinoma progression by modulating the EGFR-ERK1/2 signaling pathway

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Correction: Upregulation of SNX5 predicts poor prognosis and promotes hepatocellular carcinoma progression by modulating the EGFR-ERK1/2 signaling pathway Source link...
Cardiology

IL-10 provides cardioprotection in diabetic myocardial infarction via upregulation of Heme clearance pathways.

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Related Articles IL-10 provides cardioprotection in diabetic myocardial infarction via upregulation of Heme clearance pathways. JCI Insight. 2020 Sep 03;5(17): Authors: Gupta R, Liu L,...
Cardiology

Up-regulation of ANXA1 suppresses polymorphonuclear neutrophil infiltration and myeloperoxidase activity by activating STAT3 signaling pathway in rat models of myocardial ischemia-reperfusion injury.

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Related Articles Up-regulation of ANXA1 suppresses polymorphonuclear neutrophil infiltration and myeloperoxidase activity by activating STAT3 signaling pathway in rat models of myocardial ischemia-reperfusion injury. Cell...
Cardiology

Hypoxia exacerbates cardiomyocyte injury via upregulation of Wnt3a and inhibition of Sirt3.

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Hypoxia exacerbates cardiomyocyte injury via upregulation of Wnt3a and inhibition of Sirt3. Cytokine. 2020 Aug 17;136:155237 Authors: Li Y, Du L, Cheng S, Guo J,...
Neurology

Researchers show how upregulation of a single gene by SARs-CoV-2 can trigger cytokine storm

Newsemia
The SARS-CoV-19 virus initially has a limited capability to invade, attacking only one intracellular genetic target, the aryl hydrocarbon receptors (AhRs). Source link...
Cardiology

PDE5 inhibitor sildenafil attenuates cardiac microRNA 214 upregulation and pro-apoptotic signaling after chronic alcohol ingestion in mice.

Newsemia
Related Articles PDE5 inhibitor sildenafil attenuates cardiac microRNA 214 upregulation and pro-apoptotic signaling after chronic alcohol ingestion in mice. Mol Cell Biochem. 2020 Jun 13;:...

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