Tag : transporters

Gastroenterology

Editing Myosin VB Gene to Create Porcine Model of Microvillus Inclusion Disease, With Microvillus-lined Inclusions and Alterations in Sodium Transporters

Newsemia
Microvillus inclusion disease (MVID) is caused by inactivating mutations in the myosin VB gene (MYO5B). MVID is a complex disorder characterized by chronic, watery, life-threatening...
Cardiology

NCX and EAAT transporters in ischemia: At the crossroad between glutamate metabolism and cell survival.

Newsemia
Related Articles NCX and EAAT transporters in ischemia: At the crossroad between glutamate metabolism and cell survival. Cell Calcium. 2020 Jan 13;86:102160 Authors: Piccirillo S,...
Pharma / Biotech

Value of quantifying ABC transporters by mass spectrometry and impact on in vitro-to-in vivo prediction of transporter-mediated drug-drug interactions of rivaroxaban.

Newsemia
Related Articles Value of quantifying ABC transporters by mass spectrometry and impact on in vitro-to-in vivo prediction of transporter-mediated drug-drug interactions of rivaroxaban. Eur J...
Biology

Yeast α-arrestin Art2 is the key regulator of ubiquitylation-dependent endocytosis of plasma membrane vitamin B1 transporters

Newsemia
by Jérôme Savocco, Sylvain Nootens, Wilhelmine Afokpa, Mathilde Bausart, Xiaoqian Chen, Jennifer Villers, Henri-François Renard, Martine Prévost, Ruddy Wattiez, Pierre Morsomme Endocytosis of membrane proteins...
Pharma / Biotech

Pharmacokinetic Drug-Drug Interactions Between Trospium Chloride and Ranitidine Substrates of Organic Cation Transporters in Healthy Human Subjects.

Newsemia
Related Articles Pharmacokinetic Drug-Drug Interactions Between Trospium Chloride and Ranitidine Substrates of Organic Cation Transporters in Healthy Human Subjects. J Clin Pharmacol. 2019 Sep 22;:...
Biology

The Arabidopsis Pleiotropic Drug Resistance Transporters PEN3 and PDR12 Mediate Camalexin Secretion for Resistance to Botrytis cinerea

Newsemia
Plant defense often depends on the synthesis and targeted delivery of antimicrobial metabolites at pathogen contact sites. The pleiotropic drug resistance (PDR) transporter PENETRATION3 (PEN3)/PDR8...
Biology

Structures suggest a mechanism for energy coupling by a family of organic anion transporters

Newsemia
by Jonathan B. Leano, Samir Batarni, Jacob Eriksen, Narinobu Juge, John E. Pak, Tomomi Kimura-Someya, Yaneth Robles-Colmenares, Yoshinori Moriyama, Robert M. Stroud, Robert H. Edwards...
Pharma / Biotech

Diet-induced obese alters the expression and function of hepatic drug-metabolizing enzymes and transporters in rats.

Newsemia
Related Articles Diet-induced obese alters the expression and function of hepatic drug-metabolizing enzymes and transporters in rats. Biochem Pharmacol. 2019 May 04;: Authors: Zhang L,...
Biology

Clubroot Disease Stimulates Early Steps of Phloem Differentiation and Recruits SWEET Sucrose Transporters within Developing Galls

Newsemia
Successful biotrophic plant pathogens can divert host nutrition toward infection sites. Here we describe how the protist Plasmodiophora brassicae establishes a long-term feeding relationship with...

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