Tag : Transfer RNA

Biology

How the initiating ribosome copes with ppGpp to translate mRNAs

Newsemia
by Daria S. Vinogradova, Victor Zegarra, Elena Maksimova, Jose Alberto Nakamoto, Pavel Kasatsky, Alena Paleskava, Andrey L. Konevega, Pohl Milón During host colonization, bacteria use...
Biology

Single-molecule correlated chemical probing reveals large-scale structural communication in the ribosome and the mechanism of the antibiotic spectinomycin in living cells

Newsemia
by Arnab Sengupta, Greggory M. Rice, Kevin M. Weeks The ribosome moves between distinct structural states and is organized into multiple functional domains. Here, we...
Biology

mRNA association by aminoacyl tRNA synthetase occurs at a putative anticodon mimic and autoregulates translation in response to tRNA levels

Newsemia
by Ofri Levi, Yoav Arava Aminoacyl-tRNA synthetases (aaRSs) are well studied for their role in binding and charging tRNAs with cognate amino acids. Recent RNA...
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Unique gene therapy approach paves new way to tackle rare, inherited diseases

Newsemia
Nonsense mutations are single-letter errors in the genetic code that prematurely halt the production of critical proteins. These unfinished proteins are unable to function normally,...
Biology

Lso2 is a conserved ribosome-bound protein required for translational recovery in yeast

Newsemia
by Yinuo J. Wang, Pavanapuresan P. Vaidyanathan, Maria F. Rojas-Duran, Namrata D. Udeshi, Kristen M. Bartoli, Steven A. Carr, Wendy V. Gilbert Ribosome-binding proteins function...

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