Tag : Transcription factors

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Vitamin D could help suppress excessive T cell-mediated lung inflammation in severe COVID-19

Newsemia
As COVID-19 continues to spread over the world scientists continue to seek the reasons for the difference in disease severity from person to person. Source...
Biology

The pregnant myometrium is epigenetically activated at contractility-driving gene loci prior to the onset of labor in mice

Newsemia
by Virlana M. Shchuka, Luis E. Abatti, Huayun Hou, Nawrah Khader, Anna Dorogin, Michael D. Wilson, Oksana Shynlova, Jennifer A. Mitchell During gestation, uterine smooth...
Biology

IRE1α regulates macrophage polarization, PD-L1 expression, and tumor survival

Newsemia
by Alyssa Batista, Jeffrey J. Rodvold, Su Xian, Stephen C. Searles, Alyssa Lew, Takao Iwawaki, Gonzalo Almanza, T. Cameron Waller, Jonathan Lin, Kristen Jepsen, Hannah...
Latest News

Study provides molecular explanation to a longstanding mystery in viral oncology

Newsemia
The oncogenic herpesvirus (HHV8 or KSHV) causes a cancer known as Kaposi’s Sarcoma. An international team of scientists led by the University of Helsinki has...
Latest News

Targeting specific nuclear transport systems may lead to possible therapeutic strategies for cancer

Newsemia
Although less often the focus of cancer research, recent studies have hinted at the possible importance of a type of protein known as nuclear transport...
Biology

CEH-60/PBX regulates vitellogenesis and cuticle permeability through intestinal interaction with UNC-62/MEIS in <i>Caenorhabditis elegans</i>

Newsemia
by Pieter Van de Walle, Ellen Geens, Geert Baggerman, Francisco José Naranjo-Galindo, Peter Askjaer, Liliane Schoofs, Liesbet Temmerman The onset of sexual maturity involves dramatic...
Biology

Opposing signaling pathways regulate morphology in response to temperature in the fungal pathogen Histoplasma capsulatum

Newsemia
by Lauren Rodriguez, Mark Voorhies, Sarah Gilmore, Sinem Beyhan, Anthony Myint, Anita Sil Phenotypic switching between 2 opposing cellular states is a fundamental aspect of...
Biology

Changes in chromatin accessibility ensure robust cell cycle exit in terminally differentiated cells

Newsemia
by Yiqin Ma, Daniel J. McKay, Laura Buttitta During terminal differentiation, most cells exit the cell cycle and enter into a prolonged or permanent G0...
Biology

Dissecting the transcriptome landscape of the human fetal neural retina and retinal pigment epithelium by single-cell RNA-seq analysis

Newsemia
by Yuqiong Hu, Xiaoye Wang, Boqiang Hu, Yunuo Mao, Yidong Chen, Liying Yan, Jun Yong, Ji Dong, Yuan Wei, Wei Wang, Lu Wen, Jie Qiao,...
Biology

Simple nutrients bypass the requirement for HLH-30 in coupling lysosomal nutrient sensing to survival

Newsemia
by John T. Murphy, Haiyan Liu, Xiucui Ma, Alex Shaver, Brian M. Egan, Clara Oh, Alexander Boyko, Travis Mazer, Samuel Ang, Rohan Khopkar, Ali Javaheri,...
Biology

HSP-4/BiP expression in secretory cells is regulated by a developmental program and not by the unfolded protein response

Newsemia
by Ji Zha, Mingjie Ying, Jasmine Alexander-Floyd, Tali Gidalevitz Differentiation of secretory cells leads to sharp increases in protein synthesis, challenging endoplasmic reticulum (ER) proteostasis....
Biology

Environment-induced same-sex mating in the yeast <i>Candida albicans</i> through the Hsf1–Hsp90 pathway

Newsemia
by Guobo Guan, Li Tao, Huizhen Yue, Weihong Liang, Jiao Gong, Jian Bing, Qiushi Zheng, Amanda O. Veri, Shuru Fan, Nicole Robbins, Leah E. Cowen,...

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