Tag: Transcription factors

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Targeting specific nuclear transport systems may lead to possible therapeutic strategies for cancer

Newsemia
Although less often the focus of cancer research, recent studies have hinted at the possible importance of a type of protein known as nuclear transport...
Biology

CEH-60/PBX regulates vitellogenesis and cuticle permeability through intestinal interaction with UNC-62/MEIS in <i>Caenorhabditis elegans</i>

Newsemia
by Pieter Van de Walle, Ellen Geens, Geert Baggerman, Francisco José Naranjo-Galindo, Peter Askjaer, Liliane Schoofs, Liesbet Temmerman The onset of sexual maturity involves dramatic...
Biology

Opposing signaling pathways regulate morphology in response to temperature in the fungal pathogen Histoplasma capsulatum

Newsemia
by Lauren Rodriguez, Mark Voorhies, Sarah Gilmore, Sinem Beyhan, Anthony Myint, Anita Sil Phenotypic switching between 2 opposing cellular states is a fundamental aspect of...
Biology

Changes in chromatin accessibility ensure robust cell cycle exit in terminally differentiated cells

Newsemia
by Yiqin Ma, Daniel J. McKay, Laura Buttitta During terminal differentiation, most cells exit the cell cycle and enter into a prolonged or permanent G0...
Biology

Dissecting the transcriptome landscape of the human fetal neural retina and retinal pigment epithelium by single-cell RNA-seq analysis

Newsemia
by Yuqiong Hu, Xiaoye Wang, Boqiang Hu, Yunuo Mao, Yidong Chen, Liying Yan, Jun Yong, Ji Dong, Yuan Wei, Wei Wang, Lu Wen, Jie Qiao,...
Biology

Simple nutrients bypass the requirement for HLH-30 in coupling lysosomal nutrient sensing to survival

Newsemia
by John T. Murphy, Haiyan Liu, Xiucui Ma, Alex Shaver, Brian M. Egan, Clara Oh, Alexander Boyko, Travis Mazer, Samuel Ang, Rohan Khopkar, Ali Javaheri,...
Biology

HSP-4/BiP expression in secretory cells is regulated by a developmental program and not by the unfolded protein response

Newsemia
by Ji Zha, Mingjie Ying, Jasmine Alexander-Floyd, Tali Gidalevitz Differentiation of secretory cells leads to sharp increases in protein synthesis, challenging endoplasmic reticulum (ER) proteostasis....
Biology

Environment-induced same-sex mating in the yeast <i>Candida albicans</i> through the Hsf1–Hsp90 pathway

Newsemia
by Guobo Guan, Li Tao, Huizhen Yue, Weihong Liang, Jiao Gong, Jian Bing, Qiushi Zheng, Amanda O. Veri, Shuru Fan, Nicole Robbins, Leah E. Cowen,...
Biology

Developmental regulation of regenerative potential in <i>Drosophila</i> by ecdysone through a bistable loop of ZBTB transcription factors

Newsemia
by Karine Narbonne-Reveau, Cédric Maurange In many organisms, the regenerative capacity of tissues progressively decreases as development progresses. However, the developmental mechanisms that restrict regenerative...
Biology

Proximal recolonization by self-renewing microglia re-establishes microglial homeostasis in the adult mouse brain

Newsemia
by Lihong Zhan, Grietje Krabbe, Fei Du, Ian Jones, Meredith C. Reichert, Maria Telpoukhovskaia, Lay Kodama, Chao Wang, Seo-hyun Cho, Faten Sayed, Yaqiao Li, David...
Biology

Insulin signaling and reduced glucocorticoid receptor activity attenuate postprandial gene expression in liver

Newsemia
by Adrija Kalvisa, Majken S. Siersbæk, Stine M. Præstholm, Line J. L. Christensen, Ronni Nielsen, Oliver Stohr, Sabine Vettorazzi, Jan Tuckermann, Morris White, Susanne Mandrup,...
Biology

JMJD5 links CRY1 function and proteasomal degradation

Newsemia
by Anand R. Saran, Diana Kalinowska, Sangphil Oh, Ralf Janknecht, Luciano DiTacchio The circadian oscillator is a molecular feedback circuit whose orchestration involves posttranslational control...
Biology

<i>Jagged1/Notch2</i> controls kidney fibrosis via <i>Tfam</i>-mediated metabolic reprogramming

Newsemia
by Shizheng Huang, Jihwan Park, Chengxiang Qiu, Kiwung Chung, Szu-yuan Li, Yasemin Sirin, Seung Hyeok Han, Verdon Taylor, Ursula Zimber-Strobl, Katalin Susztak While Notch signaling...

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