toxicity

Strategy to prevent cardiac toxicity induced by polyacrylic acid decorated iron MRI contrast agent and investigation of its mechanism.

Related Articles Strategy to prevent cardiac toxicity induced by polyacrylic acid decorated iron MRI contrast agent and investigation of its mechanism. Biomaterials. 2019 Aug 22;222:119442 Authors: Fu H, Miao C,...

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Population susceptibility: A vital consideration in chemical risk evaluation under the Lautenberg Toxic Substances Control Act

by Patricia D. Koman, Veena Singla, Juleen Lam, Tracey J. Woodruff The 2016 Frank Lautenberg Chemical Safety for the 21st Century Act (Lautenberg TSCA) amended the 1976 Toxic Substances Control...

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Adolescent Cancer Survivors Face an Uphill Toxicity Fight

Aggressive identification and treatment strategies have led to an overall cure rate for childhood malignancies of greater than 80%, but an increasing number of surviving patients are developing therapy-related toxicities...

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Novel antibiotics effective against gram-positive and -negative multi-resistant bacteria with limited resistance

by Irène Nicolas, Valérie Bordeau, Arnaud Bondon, Michèle Baudy-Floc’h, Brice Felden Antibiotics are a medical wonder, but an increasing frequency of resistance among most human pathogens is rendering them ineffective....

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FDA approves new multiple myeloma drug despite toxicity concerns

The Food and Drug Administration on Wednesday approved a new drug to treat patients with multiple myeloma, overruling a panel of outside cancer experts who expressed concerns about its toxicity....

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Iron-mediated aggregation and toxicity in a novel neuronal cell culture model with inducible alpha-synuclein expression

Iron-mediated aggregation and toxicity in a novel neuronal cell culture model with inducible alpha-synuclein expression Source link

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Specific activation of pro-Infliximab enhances selectivity and safety of rheumatoid arthritis therapy

by Yun-Chi Lu, Chih-Hung Chuang, Kuo-Hsiang Chuang, I-Ju Chen, Bo-Cheng Huang, Wen-Han Lee, Hsin-Ell Wang, Jia-Je Li, Yi-An Cheng, Kai-Wen Cheng, Jaw-Yuan Wang, Yuan-Chin Hsieh, Wen-Wei Lin, Tian-Lu Cheng During...

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Newborn Infant With Mothball Toxicity Due to Maternal Ingestion

Naphthalene poisoning due to exposure to mothballs is a common cause of toxicity in children worldwide. Naphthalene toxicity is known to cause hemolytic anemia, methemoglobinemia, and hepatic and renal injury....

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The importance of inter-individual Kupffer cell variability in the governance of hepatic toxicity in a 3D primary human liver microtissue model

[ad_1] The importance of inter-individual Kupffer cell variability in the governance of hepatic toxicity in a 3D primary human liver microtissue model Source link [ad_1]

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Mechanistic investigations of the liver toxicity of the free fatty acid receptor 1 agonist fasiglifam (TAK875) and its primary metabolites.

Related Articles Mechanistic investigations of the liver toxicity of the free fatty acid receptor 1 agonist fasiglifam (TAK875) and its primary metabolites. J Biochem Mol Toxicol. 2019 May 08;:e22345 Authors:...

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Targeted Degradation of Glucose Transporters Protects against Arsenic Toxicity [Research Article]

The abundance of cell surface glucose transporters must be precisely regulated to ensure optimal growth under constantly changing environmental conditions. We recently conducted a proteomic analysis of the cellular response...

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Potential Mechanisms of Target-Independent Uptake and Toxicity of Antibody-Drug Conjugates.

Related Articles Potential Mechanisms of Target-Independent Uptake and Toxicity of Antibody-Drug Conjugates. Pharmacol Ther. 2019 Apr 24;: Authors: Mahalingaiah PK, Ciurlionis R, Durbin KR, Yeager RL, Philip BK, Bawa B,...

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Protective effects of higenamine combined with [6]-gingerol against doxorubicin-induced mitochondrial dysfunction and toxicity in H9c2 cells and potential mechanisms.

[ad_1] Related Articles Protective effects of higenamine combined with [6]-gingerol against doxorubicin-induced mitochondrial dysfunction and toxicity in H9c2 cells and potential mechanisms. Biomed Pharmacother. 2019 Apr 24;115:108881 Authors: Wen J,...

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Synthetic peptide can inhibit toxicity, aggregation of protein in Alzheimer's disease

[ad_1] Alzheimer's is a disease of aggregation. Neurons in the human brain make a protein called amyloid beta. Such proteins on their own, called monomers of amyloid beta, perform important...

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Vitamin D Toxicity: 6 Shocking Side Effects Of Hypervitaminosis D

[ad_1] Too much of a good thing can be bad, and an excess of Vitamin D can lead to a whole lot of complications. Source link [ad_2]

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Proton Therapy Demonstrates Efficacy and Reduced Toxicity in Largest-Ever Cohort of Pediatric High-Risk Neuroblastoma Patients

Researchers from Children's Hospital of Philadelphia and the Perelman School of Medicine at the University of Pennsylvania analyzed the largest cohort to date of pediatric patients with high-risk neuroblastoma treated...

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Proton therapy shows efficacy, low toxicity in large cohort of children with high-risk neuroblastoma

Researchers analyzed the largest cohort to date of pediatric patients with high-risk neuroblastoma treated with proton radiation therapy (PRT), finding both that proton therapy was effective at reducing tumors and...

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Selectivity, efficacy and toxicity studies of UCCB01-144, a dimeric neuroprotective PSD-95 inhibitor.

[ad_1] Related Articles Selectivity, efficacy and toxicity studies of UCCB01-144, a dimeric neuroprotective PSD-95 inhibitor. Neuropharmacology. 2019 Mar 02;: Authors: Bach A, Clausen BH, Kristensen LK, Andersen MG, Ellman DG,...

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Peripheral neuropathy associated with silver toxicity

Silver is known to be a potent bactericidal agent. It has a proinflammatory effect by inducing inflammatory cytokines and reactive oxygen species. Silver can also have a direct cytotoxic effect...

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Comprehensive Toxicity Assessment of PEGylated Magnetic Nanoparticles for in vivo applications.

[ad_1] Related Articles Comprehensive Toxicity Assessment of PEGylated Magnetic Nanoparticles for in vivo applications. Colloids Surf B Biointerfaces. 2019 Feb 03;177:253-259 Authors: Caro C, Egea-Benavente D, Polvillo R, Royo JL,...

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