Tag : TDP43

Neurology

Association of TDP-43 proteinopathy, cerebral amyloid angiopathy, and Lewy bodies with cognitive impairment in individuals with or without Alzheimer’s disease neuropathology

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Association of TDP-43 proteinopathy, cerebral amyloid angiopathy, and Lewy bodies with cognitive impairment in individuals with or without Alzheimer’s disease neuropathology Source link...
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TDP-43 extracted from frontotemporal lobar degeneration subject brains displays distinct aggregate assemblies and neurotoxic effects reflecting disease progression rates

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Laferrière, F; Maniecka, Z; Pérez-Berlanga, M; Hruska-Plochan, M; Gilhespy, L; Hock, E-M; Wagner, U; … Polymenidou, M; + view all Laferrière, F; Maniecka, Z; Pérez-Berlanga,...
Cardiology

Age-related deregulation of TDP-43 after stroke enhances NF-κB-mediated inflammation and neuronal damage.

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Related Articles Age-related deregulation of TDP-43 after stroke enhances NF-κB-mediated inflammation and neuronal damage. J Neuroinflammation. 2018 Nov 09;15(1):312 Authors: Thammisetty SS, Pedragosa J, Weng...
Biology

The N Termini of TAR DNA-Binding Protein 43 (TDP43) C-Terminal Fragments Influence Degradation, Aggregation Propensity, and Morphology [Research Article]

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Fragments of the TAR DNA-binding protein 43 (TDP43) are major components of intracellular aggregates associated with amyotrophic lateral sclerosis and frontotemporal dementia. A variety of...
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Senataxin mutations elicit motor neuron degeneration phenotypes and yield TDP-43 mislocalization in ALS4 mice and human patients

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Bennett, CL; Dastidar, SG; Ling, S-C; Malik, B; Ashe, T; Wadhwa, M; Miller, DB; … La Spada, AR; + view all Bennett, CL; Dastidar, SG;...

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