Tag: Tcell

Gastroenterology

Hepatocellular Carcinoma Cells Upregulate PVRL1, Stabilizing PVR and Inhibiting the Cytotoxic T-cell Response via TIGIT to Mediate Tumor Resistance to PD1 Inhibitors in Mice

Newsemia
Immune checkpoint inhibitors are effective in treatment of some hepatocellular carcinomas (HCCs), but these tumors do not always respond to inhibitors of programmed cell death...
Biology

IL-23 signaling regulation of pro-inflammatory T-cell migration uncovered by phosphoproteomics

Newsemia
by Candelas Álvarez-Salamero, Raquel Castillo-González, Gloria Pastor-Fernández, Isabel R. Mariblanca, Jesús Pino, Danay Cibrian, María N. Navarro Interleukin 23 (IL-23) triggers pathogenic features in pro-inflammatory,...
Biology

Yap suppresses T-cell function and infiltration in the tumor microenvironment

Newsemia
by Eleni Stampouloglou, Nan Cheng, Anthony Federico, Emily Slaby, Stefano Monti, Gregory L. Szeto, Xaralabos Varelas A major challenge for cancer immunotherapy is sustaining T-cell...
Biology

Modality Solutions Webinar Replay: Cold Chain Validation Best Practices Including CAR T-cell and ADC Immunotherapies

Newsemia
HOUSTON (PRWEB) November 22, 2019 Modality Solutions, biopharmaceutical cold chain engineering firm, hosted a live webinar covering a step-by-step cold chain validation guide to meet...
Biology

Immatics Implements Genedata Biologics® into Proprietary T-Cell Receptor Discovery and Engineering XCEPTOR® Platform

Newsemia
BASEL, Switzerland (PRWEB) November 12, 2019 Genedata, the leading provider of enterprise software solutions for biopharmaceutical R&D, today announced that Immatics Biotechnologies , a clinical-stage...
Neurology

Phase 2 clinical trial of CAR T-cell therapy starts at Atlantic Health System

Newsemia
Atlantic Health System is treating patients in a new Phase 2 clinical trial of CAR T-cell therapy at Morristown Medical Center. A select number of...
Pharma / Biotech

VCAM-1 Density and Tumor Perfusion Predict T-cell Infiltration and Treatment Response in Preclinical Models.

Newsemia
Related Articles VCAM-1 Density and Tumor Perfusion Predict T-cell Infiltration and Treatment Response in Preclinical Models. Neoplasia. 2019 Sep 11;21(10):1036-1050 Authors: Riegler J, Gill H,...
Latest News

Comparative analysis of melphalan versus busulphan T-cell deplete conditioning using alemtuzumab in unrelated donor stem cell transplantation for acute myeloid leukaemia

Newsemia
Sellar, RS; Mehra, V; Fox, TA; Grigg, A; Kulasekararaj, A; Sarma, A; de Lavallade, H; … Potter, VT; + view all Sellar, RS; Mehra, V;...
Biology

TSC1/mTOR-controlled metabolic–epigenetic cross talk underpins DC control of CD8<sup>+</sup> T-cell homeostasis

Newsemia
by Lei Shi, Xia Chen, Aiping Zang, Tiantian Li, Yanxiang Hu, Shixin Ma, Mengdie Lü, Huiyong Yin, Haikun Wang, Xiaoming Zhang, Bei Zhang, Qibin Leng,...
Biology

Attenuation of chronic antiviral T-cell responses through constitutive COX2-dependent prostanoid synthesis by lymph node fibroblasts

Newsemia
by Karin Schaeuble, Hélène Cannelle, Stéphanie Favre, Hsin-Ying Huang, Susanne G. Oberle, Daniel E. Speiser, Dietmar Zehn, Sanjiv A. Luther Lymphoid T-zone fibroblastic reticular cells...

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