Tag : T Cells

Biology

Lack of the MHC class II chaperone H2-O causes susceptibility to autoimmune diseases

Newsemia
by Robin A. Welsh, Nianbin Song, Catherine A. Foss, Tatiana Boronina, Robert N. Cole, Scheherazade Sadegh-Nasseri DO (HLA-DO, in human; murine H2-O) is a highly...
Biology

Yap suppresses T-cell function and infiltration in the tumor microenvironment

Newsemia
by Eleni Stampouloglou, Nan Cheng, Anthony Federico, Emily Slaby, Stefano Monti, Gregory L. Szeto, Xaralabos Varelas A major challenge for cancer immunotherapy is sustaining T-cell...
Biology

NLRX1 inhibits the early stages of CNS inflammation and prevents the onset of spontaneous autoimmunity

Newsemia
by Marjan Gharagozloo, Shaimaa Mahmoud, Camille Simard, Kenzo Yamamoto, Diwakar Bobbala, Subburaj Ilangumaran, Matthew D. Smith, Albert Lamontagne, Samir Jarjoura, Jean-Bernard Denault, Véronique Blais, Louis...
Biology

TSC1/mTOR-controlled metabolic–epigenetic cross talk underpins DC control of CD8<sup>+</sup> T-cell homeostasis

Newsemia
by Lei Shi, Xia Chen, Aiping Zang, Tiantian Li, Yanxiang Hu, Shixin Ma, Mengdie Lü, Huiyong Yin, Haikun Wang, Xiaoming Zhang, Bei Zhang, Qibin Leng,...
Biology

Attenuation of chronic antiviral T-cell responses through constitutive COX2-dependent prostanoid synthesis by lymph node fibroblasts

Newsemia
by Karin Schaeuble, Hélène Cannelle, Stéphanie Favre, Hsin-Ying Huang, Susanne G. Oberle, Daniel E. Speiser, Dietmar Zehn, Sanjiv A. Luther Lymphoid T-zone fibroblastic reticular cells...
Biology

Regulation of membrane phospholipid asymmetry by Notch-mediated flippase expression controls the number of intraepithelial TCRαβ<sup>+</sup>CD8αα<sup>+</sup> T cells

Newsemia
by Chieko Ishifune, Shin-ichi Tsukumo, Yoichi Maekawa, Katsuto Hozumi, Doo Hyun Chung, Chihiro Motozono, Sho Yamasaki, Hiroyasu Nakano, Koji Yasutomo Intestinal intraepithelial lymphocytes (IELs) expressing...
Biology

High-resolution mapping reveals that microniches in the gastric glands control <i>Helicobacter pylori</i> colonization of the stomach

Newsemia
by Connie Fung, Shumin Tan, Mifuyu Nakajima, Emma C. Skoog, Luis Fernando Camarillo-Guerrero, Jessica A. Klein, Trevor D. Lawley, Jay V. Solnick, Tadashi Fukami, Manuel...
Biology

miR-181a/b-1 controls thymic selection of Treg cells and tunes their suppressive capacity

Newsemia
by Marcin Łyszkiewicz, Samantha J. Winter, Katrin Witzlau, Lisa Föhse, Rebecca Brownlie, Jacek Puchałka, Nikita A. Verheyden, Heike Kunze-Schumacher, Esther Imelmann, Jonas Blume, Solaiman Raha,...
Biology

Intramembrane ionic protein–lipid interaction regulates integrin structure and function

Newsemia
by Jun Guo, Youhua Zhang, Hua Li, Huiying Chu, Qinshu Wang, Shutan Jiang, Yan Li, Hongbin Shen, Guohui Li, Jianfeng Chen, Chenqi Xu Protein transmembrane...
Biology

The Foxp3<sup>+</sup> regulatory T-cell population requires IL-4Rα signaling to control inflammation during helminth infections

Newsemia
by Nada Abdel Aziz, Justin Komguep Nono, Thabo Mpotje, Frank Brombacher Forkhead box P3 (Foxp3+) regulatory T (Treg)-cell function is controlled by environmental cues of...
Biology

The human lymph node microenvironment unilaterally regulates T-cell activation and differentiation

Newsemia
by Konstantin Knoblich, Sara Cruz Migoni, Susan M. Siew, Elizabeth Jinks, Baksho Kaul, Hannah C. Jeffery, Alfie T. Baker, Muath Suliman, Katerina Vrzalikova, Hisham Mehenna,...

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