Tag: Substitution mutation

Biology

Molecular basis for the PAM expansion and fidelity enhancement of an evolved Cas9 nuclease

Newsemia
by Weizhong Chen, Hongyuan Zhang, Yifei Zhang, Yu Wang, Jianhua Gan, Quanjiang Ji Clustered regularly interspaced short palindromic repeats (CRISPR)-Cas systems have been harnessed as...
Biology

Extensive loss of cell-cycle and DNA repair genes in an ancient lineage of bipolar budding yeasts

Newsemia
by Jacob L. Steenwyk, Dana A. Opulente, Jacek Kominek, Xing-Xing Shen, Xiaofan Zhou, Abigail L. Labella, Noah P. Bradley, Brandt F. Eichman, Neža Čadež, Diego...
Biology

Mutational signatures of redox stress in yeast single-strand DNA and of aging in human mitochondrial DNA share a common feature

Newsemia
by Natalya P. Degtyareva, Natalie Saini, Joan F. Sterling, Victoria C. Placentra, Leszek J. Klimczak, Dmitry A. Gordenin, Paul W. Doetsch Redox stress is a...

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