Tag : splicing

Biology

An F-Box Protein, Mdm30, Interacts with TREX Subunit Sub2 To Regulate Cellular Abundance Cotranscriptionally in Orchestrating mRNA Export Independently of Splicing and Mitochondrial Function [Research Article]

Newsemia
Although an F-box protein, Mdm30, is found to regulate ubiquitylation of the Sub2 component of TREX (transcription-export) complex for proteasomal degradation in stimulation of mRNA...
Pediatrics

New Computational Tools Identify Alternative Splicing Changes in Aggressive Cancers

Newsemia
A multi-institutional group of researchers led by Children’s Hospital of Philadelphia (CHOP) has linked a strong cancer driver gene to changes in proteins that regulate...
Biology

Heterogeneous Nuclear Ribonucleoprotein H1 Coordinates with Phytochrome and the U1 snRNP Complex to Regulate Alternative Splicing in Physcomitrella patens

Newsemia
Plant photoreceptors tightly regulate gene expression to control photomorphogenic responses. Although gene expression is modulated by photoreceptors at various levels, the regulatory mechanism at the...
Biology

Evolution of intron splicing towards optimized gene expression is based on various <i>Cis</i>- and <i>Trans</i>-molecular mechanisms

Newsemia
by Idan Frumkin, Ido Yofe, Raz Bar-Ziv, Yonat Gurvich, Yen-Yun Lu, Yoav Voichek, Ruth Towers, Dvir Schirman, Heike Krebber, Yitzhak Pilpel Splicing expands, reshapes, and...
Biology

Differential Interleukin-2 Transcription Kinetics Render Mouse but Not Human T Cells Vulnerable to Splicing Inhibition Early after Activation [Research Article]

Newsemia
T cells are nodal players in the adaptive immune response against pathogens and malignant cells. Alternative splicing plays a crucial role in T cell activation,...
AI/ML

Deep-learning augmented RNA-seq analysis of transcript splicing.

Newsemia
Related Articles Deep-learning augmented RNA-seq analysis of transcript splicing. Nat Methods. 2019 04;16(4):307-310 Authors: Zhang Z, Pan Z, Ying Y, Xie Z, Adhikari S, Phillips...

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