Tag: smallmolecule

Pharma / Biotech

A Small-Molecule Inhibitor of the Wnt Pathway, Lorecivivint (SM04690), as a Potential Disease-Modifying Agent for the Treatment of Degenerative Disc Disease.

Newsemia
A Small-Molecule Inhibitor of the Wnt Pathway, Lorecivivint (SM04690), as a Potential Disease-Modifying Agent for the Treatment of Degenerative Disc Disease. Spine J. 2020 May...
Cardiology

A small-molecule LF3 abrogates β-catenin/TCF4-mediated suppression of NaV1.5 expression in HL-1 cardiomyocytes.

Newsemia
Related Articles A small-molecule LF3 abrogates β-catenin/TCF4-mediated suppression of NaV1.5 expression in HL-1 cardiomyocytes. J Mol Cell Cardiol. 2019 Aug 13;: Authors: Zhao L, Sun...
Gastroenterology

Small-molecule inhibitors of cyclophilins block opening of the mitochondrial permeability transition pore and protect mice from hepatic ischemia–reperfusion injury

Newsemia
Hepatic ischemia–reperfusion injury is a complication of liver surgery that involves mitochondrial dysfunction resulting from mitochondrial permeability transition pore (mPTP) opening. Cyclophilin D (PPIF or...
Pharma / Biotech

Management of Acute Coronary Syndrome Using Small-Molecule Glycoprotein IIb/IIIa Inhibitors: The Contemporary Role of Aggrastat<sup>®</sup> (tirofiban hydrochloride) Injection for High-Risk Patients

Newsemia
This monograph discusses the current role of small-molecule GP IIb/IIa inhibitors in the management of patients at high risk for thrombotic events and describes the...
Pharma / Biotech

Management of Acute Coronary Syndrome Using Small-Molecule Glycoprotein IIb/IIIa Inhibitors: The Contemporary Role of Aggrastat (tirofiban hydrochloride) Injection for High-Risk Patients

Newsemia
This monograph discusses the current role of small-molecule GP IIb/IIa inhibitors in the management of patients at high risk for thrombotic events and describes the...
Pharma / Biotech

General Pharmacokinetic Features of Small-Molecule Compounds Exhibiting Target-Mediated Drug Disposition (TMDD): A Simulation-Based Study.

Newsemia
General Pharmacokinetic Features of Small-Molecule Compounds Exhibiting Target-Mediated Drug Disposition (TMDD): A Simulation-Based Study. J Clin Pharmacol. 2018 Nov 02;: Authors: Bach T, Jiang Y,...

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