Tag: Small interfering RNAs

Biology

NCX1 represents an ionic Na<sup>+</sup> sensing mechanism in macrophages

Newsemia
by Patrick Neubert, Arne Homann, David Wendelborn, Anna-Lorena Bär, Luka Krampert, Maximilian Trum, Agnes Schröder, Stefan Ebner, Andrea Weichselbaum, Valentin Schatz, Peter Linz, Roland Veelken,...
Biology

YTHDF2 promotes mitotic entry and is regulated by cell cycle mediators

Newsemia
by Qili Fei, Zhongyu Zou, Ian A. Roundtree, Hui-Lung Sun, Chuan He The N6-methyladenosine (m6A) modification regulates mRNA stability and translation. Here, we show that...
Biology

A long noncoding RNA sensitizes genotoxic treatment by attenuating ATM activation and homologous recombination repair in cancers

Newsemia
by Kunming Zhao, Xingwen Wang, Xuting Xue, Li Li, Ying Hu Ataxia-telangiectasia mutated (ATM) is an apical kinase of the DNA damage response following DNA...
Biology

Control over single-cell distribution of G1 lengths by WNT governs pluripotency

Newsemia
by Jiwon Jang, Dasol Han, Mahdi Golkaram, Morgane Audouard, Guojing Liu, Daniel Bridges, Stefan Hellander, Alex Chialastri, Siddharth S. Dey, Linda R. Petzold, Kenneth S....
Biology

Reticulon and CLIMP-63 regulate nanodomain organization of peripheral ER tubules

Newsemia
by Guang Gao, Chengjia Zhu, Emma Liu, Ivan R. Nabi The endoplasmic reticulum (ER) is an expansive, membrane-enclosed organelle composed of smooth peripheral tubules and...
Biology

DPPA2/4 and SUMO E3 ligase PIAS4 opposingly regulate zygotic transcriptional program

Newsemia
by Yao-Long Yan, Chao Zhang, Jing Hao, Xue-Lian Wang, Jia Ming, Li Mi, Jie Na, Xinli Hu, Yangming Wang The molecular mechanism controlling the zygotic...
Biology

Phenotypic selection with an intrabody library reveals an anti-apoptotic function of PKM2 requiring Mitofusin-1

Newsemia
by Tong Liu, Tomomi Kuwana, Hongkai Zhang, Matthew G. Vander Heiden, Richard A. Lerner, Donald D. Newmeyer Bcl-2 family proteins control a decisive apoptotic event:...
Biology

AMPK regulates germline stem cell quiescence and integrity through an endogenous small RNA pathway

Newsemia
by Pratik Kadekar, Richard Roy During suboptimal growth conditions, Caenorhabditis elegans larvae undergo a global developmental arrest called “dauer.” During this stage, the germline stem...
Biology

G1/S cell cycle regulators mediate effects of circadian dysregulation on tumor growth and provide targets for timed anticancer treatment

Newsemia
by Yool Lee, Nicholas F. Lahens, Shirley Zhang, Joseph Bedont, Jeffrey M. Field, Amita Sehgal Circadian disruption has multiple pathological consequences, but the underlying mechanisms...
Biology

Spontaneously slow-cycling subpopulations of human cells originate from activation of stress-response pathways

Newsemia
by Mingwei Min, Sabrina L. Spencer Slow-cycling subpopulations exist in bacteria, yeast, and mammalian systems. In the case of cancer, slow-cycling subpopulations have been proposed...
Biology

TRIM2, a novel member of the antiviral family, limits New World arenavirus entry

Newsemia
by Nicolas Sarute, Nouhou Ibrahim, Bani Medegan Fagla, Madakasira Lavanya, Christian Cuevas, Spyridon Stavrou, Guliz Otkiran-Clare, Henna Tyynismaa, Jorge Henao-Mejia, Susan R. Ross Tripartite motif...
Biology

The Cdk8/19-cyclin C transcription regulator functions in genome replication through metazoan Sld7

Newsemia
by Kerstin Köhler, Luis Sanchez-Pulido, Verena Höfer, Anika Marko, Chris P. Ponting, Ambrosius P. Snijders, Regina Feederle, Aloys Schepers, Dominik Boos Accurate genome duplication underlies...
Biology

JMJD5 links CRY1 function and proteasomal degradation

Newsemia
by Anand R. Saran, Diana Kalinowska, Sangphil Oh, Ralf Janknecht, Luciano DiTacchio The circadian oscillator is a molecular feedback circuit whose orchestration involves posttranslational control...
Biology

Noncoding RNA Ginir functions as an oncogene by associating with centrosomal proteins

Newsemia
by Suchismita Panda, Meenakshi Setia, Navjot Kaur, Varsha Shepal, Vivek Arora, Divya Kumari Singh, Abir Mondal, Abhishek Teli, Madhura Tathode, Rajendra Gajula, L. C. Padhy,...
Biology

Refined RIP-seq protocol for epitranscriptome analysis with low input materials

Newsemia
by Yong Zeng, Shiyan Wang, Shanshan Gao, Fraser Soares, Musadeqque Ahmed, Haiyang Guo, Miranda Wang, Junjie Tony Hua, Jiansheng Guan, Michael F. Moran, Ming Sound...

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