Tag : Sequence motif analysis

Biology

ORANGE: A CRISPR/Cas9-based genome editing toolbox for epitope tagging of endogenous proteins in neurons

Newsemia
by Jelmer Willems, Arthur P. H. de Jong, Nicky Scheefhals, Eline Mertens, Lisa A. E. Catsburg, Rogier B. Poorthuis, Fred de Winter, Joost Verhaagen, Frank...
Biology

A compact Cas9 ortholog from <i>Staphylococcus Auricularis</i> (SauriCas9) expands the DNA targeting scope

Newsemia
by Ziying Hu, Shuai Wang, Chengdong Zhang, Ning Gao, Miaomiao Li, Deqian Wang, Daqi Wang, Dong Liu, Huihui Liu, Sang-Ging Ong, Hongyan Wang, Yongming Wang...
Biology

How the initiating ribosome copes with ppGpp to translate mRNAs

Newsemia
by Daria S. Vinogradova, Victor Zegarra, Elena Maksimova, Jose Alberto Nakamoto, Pavel Kasatsky, Alena Paleskava, Andrey L. Konevega, Pohl Milón During host colonization, bacteria use...
Biology

Transcriptional regulatory divergence underpinning species-specific learned vocalization in songbirds

Newsemia
by Hongdi Wang, Azusa Sawai, Noriyuki Toji, Rintaro Sugioka, Yukino Shibata, Yuika Suzuki, Yu Ji, Shin Hayase, Satoru Akama, Jun Sese, Kazuhiro Wada Learning of...
Biology

Molecular basis for the PAM expansion and fidelity enhancement of an evolved Cas9 nuclease

Newsemia
by Weizhong Chen, Hongyuan Zhang, Yifei Zhang, Yu Wang, Jianhua Gan, Quanjiang Ji Clustered regularly interspaced short palindromic repeats (CRISPR)-Cas systems have been harnessed as...
Biology

N-terminal β-strand underpins biochemical specialization of an ATG8 isoform

Newsemia
by Erin K. Zess, Cassandra Jensen, Neftaly Cruz-Mireles, Juan Carlos De la Concepcion, Jan Sklenar, Madlen Stephani, Richard Imre, Elisabeth Roitinger, Richard Hughes, Khaoula Belhaj,...
Biology

Evolution of protein kinase substrate recognition at the active site

Newsemia
by David Bradley, Pedro Beltrao Protein kinases catalyse the phosphorylation of target proteins, controlling most cellular processes. The specificity of serine/threonine kinases is partly determined...
Biology

A unified mechanism for LLPS of ALS/FTLD-causing FUS as well as its modulation by ATP and oligonucleic acids

Newsemia
by Jian Kang, Liangzhong Lim, Yimei Lu, Jianxing Song 526-residue Fused in sarcoma (FUS) undergoes liquid–liquid phase separation (LLPS) for its functions, which can further...
Biology

Detecting T cell receptors involved in immune responses from single repertoire snapshots

Newsemia
by Mikhail V. Pogorelyy, Anastasia A. Minervina, Mikhail Shugay, Dmitriy M. Chudakov, Yuri B. Lebedev, Thierry Mora, Aleksandra M. Walczak Hypervariable T cell receptors (TCRs)...
Biology

Phosphorylation of the VAR2CSA extracellular region is associated with enhanced adhesive properties to the placental receptor CSA

Newsemia
by Dominique Dorin-Semblat, Marilou Tétard, Aurélie Claës, Jean-Philippe Semblat, Sébastien Dechavanne, Zaineb Fourati, Romain Hamelin, Florence Armand, Graziella Matesic, Sofia Nunes-Silva, Anand Srivastava, Stéphane Gangnard,...
Biology

Proteome-wide analysis of chaperone-mediated autophagy targeting motifs

Newsemia
by Philipp Kirchner, Mathieu Bourdenx, Julio Madrigal-Matute, Simoni Tiano, Antonio Diaz, Boris A. Bartholdy, Britta Will, Ana Maria Cuervo Chaperone-mediated autophagy (CMA) contributes to the...
Biology

A novel evolutionary conserved mechanism of RNA stability regulates synexpression of primordial germ cell-specific genes prior to the sex-determination stage in medaka

Newsemia
by Amaury Herpin, Cornelia Schmidt, Susanne Kneitz, Clara Gobé, Martina Regensburger, Aurélie Le Cam, Jérome Montfort, Mateus C. Adolfi, Christina Lillesaar, Dagmar Wilhelm, Michael Kraeussling,...
Biology

Comprehensive profiling of the STE20 kinase family defines features essential for selective substrate targeting and signaling output

Newsemia
by Chad J. Miller, Hua Jane Lou, Craig Simpson, Bert van de Kooij, Byung Hak Ha, Oriana S. Fisher, Natasha L. Pirman, Titus J. Boggon,...
Biology

Phosphodiesterase beta is the master regulator of cAMP signalling during malaria parasite invasion

Newsemia
by Christian Flueck, Laura G. Drought, Andrew Jones, Avnish Patel, Abigail J. Perrin, Eloise M. Walker, Stephanie D. Nofal, Ambrosius P. Snijders, Michael J. Blackman,...
Biology

Contingency in the convergent evolution of a regulatory network: Dosage compensation in <i>Drosophila</i>

Newsemia
by Chris Ellison, Doris Bachtrog The repeatability or predictability of evolution is a central question in evolutionary biology and most often addressed in experimental evolution...
Biology

Molecular recognition and maturation of SOD1 by its evolutionarily destabilised cognate chaperone hCCS

Newsemia
by Fernanda A. Sala, Gareth S. A. Wright, Svetlana V. Antonyuk, Richard C. Garratt, S. Samar Hasnain Superoxide dismutase-1 (SOD1) maturation comprises a string of...
Biology

Genome-wide functional analyses of plant coiled–coil NLR-type pathogen receptors reveal essential roles of their N-terminal domain in oligomerization, networking, and immunity

Newsemia
by Tadeusz Wróblewski, Laurentiu Spiridon, Eliza Cristina Martin, Andrei-Jose Petrescu, Keri Cavanaugh, Maria Jose-Truco, Huaqin Xu, Dariusz Gozdowski, Krzysztof Pawłowski, Richard W. Michelmore, Frank L.W....

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