RNA

Cutting the test time for disease biomarkers using extracellular vesicles

When an individual has cancer, or any number of other diseases, early detection can make a huge difference in the outcome. A research team led by the University of Notre...

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Dicerna doses first patient in trial of RNA inhibitor for chronic HBV

[ad_1] Dicerna dosed the first patient in a phase 1 clinical trial for DCR-HBVS, an investigational GalXCTM-based therapy for the treatment of chronic hepatitis B, according to a press release.“Dosing...

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Insulin-producing beta cells can change their function in diabetes, reveals study

[ad_1] A revolutionary new study using only materials derived from humans has revealed that insulin-producing beta cells can change their function in diabetes - and that this change may be...

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Harvard scientists uncover key mechanism that allows viruses to replicate

[ad_1] Viruses are masterful invaders. They cannibalize host cells by injecting their genetic material, often making thousands of copies of themselves in a single cell to ensure their replication and...

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Single nucleosome imaging reveals loose genome chromatin networks via active RNA polymerase II

Although chromatin organization and dynamics play a critical role in gene transcription, how they interplay remains unclear. To approach this issue, we investigated genome-wide chromatin behavior under various transcriptional conditions...

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Correction to: Serum HBV RNA quantification: useful for monitoring natural history of chronic hepatitis B infection

[ad_1] Following publication of the original article [1] Source link [ad_1]

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The RNA Export Factor ALY1 Enables Genome-Wide RNA-Directed DNA Methylation

RNA-directed DNA methylation (RdDM) is a set of mechanisms by which transcriptionally repressive DNA and histone methylation are targeted to viruses, transposable elements, and some transgenes. We identified an Arabidopsis...

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Active RNA polymerase II curbs chromatin movement

Chromosomes are not very mobile during interphase. In this issue, Nagashima et al. (2019. J. Cell Biol. https://doi.org/10.1083/jcb.201811090) propose that the overall stabilization of genome structure is achieved by loose...

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The enigma of circular RNA

The post The enigma of circular RNA appeared first on Biochemistry Blog: Biochemistry Help. Source link

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MIT researchers develop novel method for analyzing massive cell datasets

[ad_1] Data-sampling method makes "sketches" of unwieldy biological datasets while still capturing the full diversity of cell types. Source link [ad_2]

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Assessing the Response of Small RNA Populations to Allopolyploidy Using Resynthesized Brassica napus Allotetraploids

AbstractAllopolyploidy, combining interspecific hybridization with whole genome duplication, has had significant impact on plant evolution. Its evolutionary success is related to the rapid and profound genome reorganizations that allow neoallopolyploids...

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Researchers uncover potential clue to halt destruction of nerve cells in people with ALS

A special focus on rogue proteins may hold future promise in stopping the progression of nerve cell destruction in people who have amyotrophic lateral sclerosis or frontotemporal dementia. Source link

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Uncovering the Structure of HIV Integrase to Inform Drug Discovery

[ad_1] In this interview Dr Kushol Gupta, Research Assistant Professor in the Department of Biochemistry and Biophysics at the Perelman School of Medicine, University of Pennsylvania talks to News-Medical and...

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Novel ECCITE-seq technique expands multimodal single cell analysis

[ad_1] A new technique called ECCITE-seq, developed by scientists at the New York Genome Center's Technology Innovation Lab, allows researchers to perform high-throughput measurements of multiple modalities of information from...

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RNA binding to p62 impacts selective autophagy

The post RNA binding to p62 impacts selective autophagy appeared first on Biochemistry Blog: Biochemistry Help. Source link

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Researchers discover critical RNA processing aberrations

[ad_1] Research by a Barrow Neurological Center scientist on mechanisms of dysfunctional RNA processing in ALS and frontaltemporal dementia (FTD) was published in the April issue of Acta Neuropathologica. The...

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STAT Plus: Drugging the undruggable and other challenges on the road to targeting RNA with pills

[ad_1] Michael Gilman is the CEO of a biotech startup showing early progress on a technology that was once thought to be impossible, but which may herald an entirely new...

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A biotech startup’s lofty goal: Kill cancer with pills that target RNA instead of proteins

[ad_1] Arrakis Therapeutics is named for the desert planet in the legendary “Dune” series of science-fiction novels. It’s an apt name because the Waltham, Mass., startup is trying to achieve...

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RNA Binding Motif Protein 48 Is Required for U12 Splicing and Maize Endosperm Differentiation

The last eukaryotic common ancestor had two classes of introns that are still found in most eukaryotic lineages. Common U2-type and rare U12-type introns are spliced by the major and...

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Serum HBV RNA quantification: useful for monitoring natural history of chronic hepatitis B infection

[ad_1] As an alternative biomarker of intrahepatic covalently closed circular DNA (cccDNA) transcriptional activity, hepatitis B virus (HBV) RNA may evolve during long-lasting virus-host interactions during chronic h... Source link...

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