Tag : RNA sequencing

Biology

Back-spliced RNA from retrotransposon binds to centromere and regulates centromeric chromatin loops in maize

Newsemia
by Yalin Liu, Handong Su, Jing Zhang, Yang Liu, Chao Feng, Fangpu Han In most plants, centromeric DNA contains highly repetitive sequences, including tandem repeats...
Latest News

MIT researchers develop method to isolate T cells primed for certain allergies or infections

Newsemia
When your immune system is exposed to a vaccine, an allergen, or an infectious microbe, subsets of T cells that can recognize a foreign intruder...
Biology

Recurrent functional misinterpretation of RNA-seq data caused by sample-specific gene length bias

Newsemia
by Shir Mandelboum, Zohar Manber, Orna Elroy-Stein, Ran Elkon Data normalization is a critical step in RNA sequencing (RNA-seq) analysis, aiming to remove systematic effects...
Gastroenterology

Mount Sinai researchers discover drug resistance signature in Crohn's disease

Newsemia
By mapping out more than 100,000 immune cells in patients with Crohn’s disease, Mount Sinai researchers have discovered a signature of cells that are involved...
Biology

Tagger—A Swiss army knife for multiomics to dissect cell type–specific mechanisms of gene expression in mice

Newsemia
by Lech Kaczmarczyk, Vikas Bansal, Ashish Rajput, Raza-ur Rahman, Wiesław Krzyżak, Joachim Degen, Stefanie Poll, Martin Fuhrmann, Stefan Bonn, Walker Scot Jackson A deep understanding...
Latest News

Study maps bone marrow niche populations and their differentiation paths

Newsemia
Bone marrow contains biological factories, which pump out billions of new blood cells daily. The non-blood cells that maintain this production also have the potential...
Biology

Ancient RNA from Late Pleistocene permafrost and historical canids shows tissue-specific transcriptome survival

Newsemia
by Oliver Smith, Glenn Dunshea, Mikkel-Holger S. Sinding, Sergey Fedorov, Mietje Germonpre, Hervé Bocherens, M. T. P. Gilbert While sequencing ancient DNA (aDNA) from archaeological...
Latest News

Researchers use artificial intelligence to predict molecular classification of colorectal cancer

Newsemia
Treating physicians need information about the molecular subtype of the tumor if they are to provide targeted therapy for colorectal carcinoma. Source link...
Biology

DPPA2/4 and SUMO E3 ligase PIAS4 opposingly regulate zygotic transcriptional program

Newsemia
by Yao-Long Yan, Chao Zhang, Jing Hao, Xue-Lian Wang, Jia Ming, Li Mi, Jie Na, Xinli Hu, Yangming Wang The molecular mechanism controlling the zygotic...
Biology

G1/S cell cycle regulators mediate effects of circadian dysregulation on tumor growth and provide targets for timed anticancer treatment

Newsemia
by Yool Lee, Nicholas F. Lahens, Shirley Zhang, Joseph Bedont, Jeffrey M. Field, Amita Sehgal Circadian disruption has multiple pathological consequences, but the underlying mechanisms...
Biology

Evidence that alternative transcriptional initiation is largely nonadaptive

Newsemia
by Chuan Xu, Joong-Ki Park, Jianzhi Zhang Alternative transcriptional initiation (ATI) refers to the frequent observation that one gene has multiple transcription start sites (TSSs)....

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