Tag : RNA interference

Biology

Back-spliced RNA from retrotransposon binds to centromere and regulates centromeric chromatin loops in maize

Newsemia
by Yalin Liu, Handong Su, Jing Zhang, Yang Liu, Chao Feng, Fangpu Han In most plants, centromeric DNA contains highly repetitive sequences, including tandem repeats...
Biology

Intestinal peroxisomal fatty acid β-oxidation regulates neural serotonin signaling through a feedback mechanism

Newsemia
by Aude D. Bouagnon, Lin Lin, Shubhi Srivastava, Chung-Chih Liu, Oishika Panda, Frank C. Schroeder, Supriya Srinivasan, Kaveh Ashrafi The ability to coordinate behavioral responses...
Latest News

ICR scientists carry out first comprehensive assessment of chemical probe resources

Newsemia
A new report urges biomedical researchers to use online web resources very carefully, taking into account their complementary benefits and weaknesses, when selecting small-molecule chemical...
Biology

CEH-60/PBX regulates vitellogenesis and cuticle permeability through intestinal interaction with UNC-62/MEIS in <i>Caenorhabditis elegans</i>

Newsemia
by Pieter Van de Walle, Ellen Geens, Geert Baggerman, Francisco José Naranjo-Galindo, Peter Askjaer, Liliane Schoofs, Liesbet Temmerman The onset of sexual maturity involves dramatic...
Biology

Dynamic evolution in the key honey bee pathogen deformed wing virus: Novel insights into virulence and competition using reverse genetics

Newsemia
by Eugene V. Ryabov, Anna K. Childers, Dawn Lopez, Kyle Grubbs, Francisco Posada-Florez, Daniel Weaver, William Girten, Dennis vanEngelsdorp, Yanping Chen, Jay D. Evans The...
Biology

Opposing signaling pathways regulate morphology in response to temperature in the fungal pathogen Histoplasma capsulatum

Newsemia
by Lauren Rodriguez, Mark Voorhies, Sarah Gilmore, Sinem Beyhan, Anthony Myint, Anita Sil Phenotypic switching between 2 opposing cellular states is a fundamental aspect of...
Biology

MDT-15/MED15 permits longevity at low temperature via enhancing lipidostasis and proteostasis

Newsemia
by Dongyeop Lee, Seon Woo A. An, Yoonji Jung, Yasuyo Yamaoka, Youngjae Ryu, Grace Ying Shyen Goh, Arshia Beigi, Jae-Seong Yang, Gyoo Yeol Jung, Dengke...
Biology

AMPK regulates germline stem cell quiescence and integrity through an endogenous small RNA pathway

Newsemia
by Pratik Kadekar, Richard Roy During suboptimal growth conditions, Caenorhabditis elegans larvae undergo a global developmental arrest called “dauer.” During this stage, the germline stem...
Biology

CRL4<sup>Mahj</sup> E3 ubiquitin ligase promotes neural stem cell reactivation

Newsemia
by Phuong Thao Ly, Ye Sing Tan, Chwee Tat Koe, Yingjie Zhang, Gengqiang Xie, Sharyn Endow, Wu-Min Deng, Fengwei Yu, Hongyan Wang The ability of...
Biology

Systematically improved in vitro culture conditions reveal new insights into the reproductive biology of the human parasite <i>Schistosoma mansoni</i>

Newsemia
by Jipeng Wang, Rui Chen, James J. Collins III Schistosomes infect over 200 million people. The prodigious egg output of these parasites is the sole...
Biology

HSP-4/BiP expression in secretory cells is regulated by a developmental program and not by the unfolded protein response

Newsemia
by Ji Zha, Mingjie Ying, Jasmine Alexander-Floyd, Tali Gidalevitz Differentiation of secretory cells leads to sharp increases in protein synthesis, challenging endoplasmic reticulum (ER) proteostasis....
Biology

The histone methyltransferase G9a regulates tolerance to oxidative stress–induced energy consumption

Newsemia
by Human Riahi, Carlijn Brekelmans, Sarah Foriel, Sarah H. Merkling, Taylor A. Lyons, Pavel M. Itskov, Tjitske Kleefstra, Carlos Ribeiro, Ronald P. van Rij, Jamie...
Biology

A single pair of leucokinin neurons are modulated by feeding state and regulate sleep–metabolism interactions

Newsemia
by Maria E. Yurgel, Priyanka Kakad, Meet Zandawala, Dick R. Nässel, Tanja A. Godenschwege, Alex C. Keene Dysregulation of sleep and feeding has widespread health...
Biology

Developmental regulation of regenerative potential in <i>Drosophila</i> by ecdysone through a bistable loop of ZBTB transcription factors

Newsemia
by Karine Narbonne-Reveau, Cédric Maurange In many organisms, the regenerative capacity of tissues progressively decreases as development progresses. However, the developmental mechanisms that restrict regenerative...
Biology

Identification and characterization of a mosquito-specific eggshell organizing factor in <i>Aedes aegypti</i> mosquitoes

Newsemia
by Jun Isoe, Lauren E. Koch, Yurika E. Isoe, Alberto A. Rascón Jr., Heidi E. Brown, Brooke B. Massani, Roger L. Miesfeld Mosquito-borne diseases are...
Latest News

Alnylam announces positive results from Phase 1/2 study of lumasiran for treating primary hyperoxaluria-1

Newsemia
Alnylam Pharmaceuticals, Inc., the leading RNAi therapeutics company, announced today updated positive results from its Phase 1/2 clinical study of lumasiran, an investigational, subcutaneously administered...
Latest News

Alnylam reports further progress on broadening the therapeutic potential of RNAi

Newsemia
Alnylam Pharmaceuticals, Inc., the leading RNAi therapeutics company, announced today further progress on the Company’s platform efforts in extrahepatic delivery of novel siRNA conjugates, including...
Biology

Midgut-derived neuropeptide F controls germline stem cell proliferation in a mating-dependent manner

Newsemia
by Tomotsune Ameku, Yuto Yoshinari, Michael J. Texada, Shu Kondo, Kotaro Amezawa, Goro Yoshizaki, Yuko Shimada-Niwa, Ryusuke Niwa Stem cell maintenance is established by neighboring...

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