Tag: regulates

Biology

IRE1α regulates macrophage polarization, PD-L1 expression, and tumor survival

Newsemia
by Alyssa Batista, Jeffrey J. Rodvold, Su Xian, Stephen C. Searles, Alyssa Lew, Takao Iwawaki, Gonzalo Almanza, T. Cameron Waller, Jonathan Lin, Kristen Jepsen, Hannah...
Biology

Mitotic phosphorylation of the ULK complex regulates cell cycle progression

Newsemia
by Akinori Yamasaki, Yui Jin, Yoshinori Ohsumi Autophagy is an intracellular degradation pathway targeting organelles and macromolecules, thereby regulating various cellular functions. Phosphorylation is a...
Biology

Tumor Necrosis Factor Alpha Regulates Skeletal Myogenesis by Inhibiting SP1 Interaction with cis-Acting Regulatory Elements within the Fbxl2 Gene Promoter [Research Article]

Newsemia
FBXL2 is an important ubiquitin E3 ligase component that modulates inflammatory signaling and cell cycle progression, but its molecular regulation is largely unknown. Here, we...
Gastroenterology

Creatine Transporter, Reduced in Colon Tissues From Patients With Inflammatory Bowel Diseases, Regulates Energy Balance in Intestinal Epithelial Cells, Epithelial Integrity, and Barrier Function

Newsemia
Patients with inflammatory bowel diseases (IBD) have intestinal barrier dysfunction. Creatine regulates energy distribution within cells and reduces the severity of colitis in mice. We...
Biology

Mutual Balance of Histone Deacetylases 1 and 2 and the Acetyl Reader ATAD2 Regulates the Level of Acetylation of Histone H4 on Nascent Chromatin of Human Cells [Research Article]

Newsemia
Newly synthesized histone H4 that is incorporated into chromatin during DNA replication is acetylated on lysines 5 and 12. Histone deacetylase 1 (HDAC1) and HDAC2...

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