Tag : randomised

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The clinical and cost-effectiveness of a Victim Improvement Package (VIP) for the reduction of chronic symptoms of depression or anxiety in older victims of common crime (the VIP trial): study protocol for a randomised controlled trial

Newsemia
Serfaty, M; Aspden, T; Satchell, J; Kessel, A; Laycock, G; Brewin, CR; Buszewicz, M; … Blanchard, M; + view all Serfaty, M; Aspden, T; Satchell,...
Latest News

Improved two-stage estimation to adjust for treatment switching in randomised trials: g-estimation to address time-dependent confounding

Newsemia
Latimer, NR; White, IR; Tilling, K; Siebert, U; (2020) Improved two-stage estimation to adjust for treatment switching in randomised trials: g-estimation to address time-dependent confounding....
Latest News

Sample size calculation in randomised phase II selection trials using a margin of practical equivalence

Newsemia
Dehbi, H-M; Hackshaw, A; (2020) Sample size calculation in randomised phase II selection trials using a margin of practical equivalence. Trials , 21 , Article...
Cardiology

A Three-Part, Randomised Study to Investigate the Safety, Tolerability, Pharmacokinetics and Mode of Action of BC 007, Neutraliser of Pathogenic Autoantibodies Against G-Protein Coupled Receptors in Healthy, Young and Elderly Subjects.

Newsemia
Related Articles A Three-Part, Randomised Study to Investigate the Safety, Tolerability, Pharmacokinetics and Mode of Action of BC 007, Neutraliser of Pathogenic Autoantibodies Against G-Protein...
Cardiology

Infant respiratory syncytial virus prophylaxis and nasopharyngeal microbiota until 6 years of life: a subanalysis of the MAKI randomised controlled trial.

Newsemia
Related Articles Infant respiratory syncytial virus prophylaxis and nasopharyngeal microbiota until 6 years of life: a subanalysis of the MAKI randomised controlled trial. Lancet Respir...
Pharma / Biotech

Safety, Pharmacokinetics and Pharmacodynamics of Branebrutinib (BMS-986195), a Covalent, Irreversible Inhibitor of Bruton's Tyrosine Kinase: Randomised Phase I, Placebo-Controlled Trial in Healthy Participants.

Newsemia
Safety, Pharmacokinetics and Pharmacodynamics of Branebrutinib (BMS-986195), a Covalent, Irreversible Inhibitor of Bruton’s Tyrosine Kinase: Randomised Phase I, Placebo-Controlled Trial in Healthy Participants. Br J...
Latest News

Reducing expectations for antibiotics in primary care: a randomised experiment to test the response to fear based messages about antimicrobial resistance

Newsemia
Roope, L; Tonkin-Crine, S; Herd, N; Michie, S; Pouwels, K; Castro-Sanchez, E; Sallis, A; … Wordsworth, S; + view all Roope, L; Tonkin-Crine, S; Herd,...
Cardiology

Survival, Prevalence, Progression and Repair of Abdominal Aortic Aneurysms: Results from Three Randomised Controlled Screening Trials Over Three Decades.

Newsemia
Related Articles Survival, Prevalence, Progression and Repair of Abdominal Aortic Aneurysms: Results from Three Randomised Controlled Screening Trials Over Three Decades. Clin Epidemiol. 2020;12:95-103 Authors:...
Latest News

CALIBER – A phase II randomised feasibility trial of chemoablation with mitomycin versus surgical management in low risk non-muscle invasive bladder cancer

Newsemia
Mostafid, AH; Porta, N; Cresswell, J; Griffiths, T; Kelly, JD; Penegar, SR; Davenport, K; … Hall, E; + view all Mostafid, AH; Porta, N; Cresswell,...
AI/ML

Haptic vs sensorimotor training in the treatment of upper limb dysfunction in multiple sclerosis: A multi-center, randomised controlled trial.

Newsemia
Related Articles Haptic vs sensorimotor training in the treatment of upper limb dysfunction in multiple sclerosis: A multi-center, randomised controlled trial. J Neurol Sci. 2020...
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Antiretroviral therapy alone versus antiretroviral therapy with a kick and kill approach, on measures of the HIV reservoir in participants with recent HIV infection (the RIVER trial): a phase 2, randomised trial

Newsemia
Fidler, S; Stöhr, W; Pace, M; Dorrell, L; Lever, A; Pett, S; Kinloch-de Loes, S; … RIVER trial study group, ; + view all Fidler,...
Cardiology

Reducing weight and increasing physical activity in people at high risk of cardiovascular disease: a randomised controlled trial comparing the effectiveness of enhanced motivational interviewing intervention with usual care

Newsemia
Objective The epidemic of obesity is contributing to the increasing prevalence of people at high risk of cardiovascular disease (CVD), negating the medical advances in...
Gastroenterology

P062 A SYSTEMATIC REVIEW ON POWER ESTIMATION TO SUPPORT SAMPLE SIZE CALCULATION FOR RANDOMISED TRIALS IN INFLAMMATORY BOWEL DISEASE

Newsemia
Inflammatory bowel disease is a collection of disorders of the gastrointestinal tract, characterised by relapsing and remitting inflammation. Studies have reported several pharmacological or non-pharmacological...
Pharma / Biotech

Methotrexate effect on immunogenicity and long-term maintenance of adalimumab in axial spondyloarthritis: a multicentric randomised trial.

Newsemia
Related Articles Methotrexate effect on immunogenicity and long-term maintenance of adalimumab in axial spondyloarthritis: a multicentric randomised trial. RMD Open. 2020 Jan;6(1): Authors: Ducourau E,...
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An exploratory parallel-group randomised controlled trial of antenatal Guided Self-Help (plus usual care) versus usual care alone for pregnant women with depression: DAWN trial

Newsemia
Trevillion, K; Ryan, EG; Pickles, A; Heslin, M; Byford, S; Nath, S; Bick, D; … Howard, LM; + view all Trevillion, K; Ryan, EG; Pickles,...
Latest News

A randomised comparison of the effect of haemodynamic monitoring with CardioMEMS in addition to standard care on quality of life and hospitalisations in patients with chronic heart failure Design and rationale of the MONITOR HF multicentre randomised clinical trial

Newsemia
Brugts, JJ; Veenis, JF; Radhoe, SP; Linssen, GCM; van Gent, M; Borleffs, CJW; van Ramshorst, J; … de Boer, RA; + view all Brugts, JJ;...
Cardiology

Rationale and design of the AFFIRM-AHF trial: a randomised, double-blind, placebo-controlled trial comparing the effect of intravenous ferric carboxymaltose on hospitalisations and mortality in iron-deficient patients admitted for acute heart failure.

Newsemia
Rationale and design of the AFFIRM-AHF trial: a randomised, double-blind, placebo-controlled trial comparing the effect of intravenous ferric carboxymaltose on hospitalisations and mortality in iron-deficient...
Gastroenterology

Effects of alternate-day fasting on body weight and dyslipidaemia in patients with non-alcoholic fatty liver disease: a randomised controlled trial

Newsemia
Alternate-day fasting (ADF) is a novel diet therapy that may achieve reduction in body weight and improvement of dyslipidaemia, but the impact of this diet...

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