Tag : Protein structure

AI/ML

Structure guided prediction of Pyrazinamide resistance mutations in pncA.

Newsemia
Related Articles Structure guided prediction of Pyrazinamide resistance mutations in pncA. Sci Rep. 2020 02 05;10(1):1875 Authors: Karmakar M, Rodrigues CHM, Horan K, Denholm JT,...
Biology

Cryo-EM structures of the human PA200 and PA200-20S complex reveal regulation of proteasome gate opening and two PA200 apertures

Newsemia
by Hongxin Guan, Youwang Wang, Ting Yu, Yini Huang, Mianhuan Li, Abdullah F. U. H. Saeed, Vanja Perčulija, Daliang Li, Jia Xiao, Dongmei Wang, Ping...
Biology

A polymorphic helix of a Salmonella needle protein relays signals defining distinct steps in type III secretion

Newsemia
by Emily Z. Guo, Daniel C. Desrosiers, Jan Zalesak, James Tolchard, Mélanie Berbon, Birgit Habenstein, Thomas Marlovits, Antoine Loquet, Jorge E. Galán Type III protein-secretion...
AI/ML

Model learns how individual amino acids determine protein function

Newsemia
A machine-learning model from MIT researchers computationally breaks down how segments of amino acid chains determine a protein’s function, which could help researchers design and...

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