Tag : Piperazines / therapeutic use

Pharma / Biotech

Structure-Based Design and Pharmacokinetic Optimization of Covalent Allosteric Inhibitors of the Mutant GTPase KRASG12C.

Newsemia
Related Articles Structure-Based Design and Pharmacokinetic Optimization of Covalent Allosteric Inhibitors of the Mutant GTPase KRASG12C. J Med Chem. 2020 05 14;63(9):4468-4483 Authors: Kettle JG,...
Dentistry

A Runaway PRH/HHEX-Notch3-Positive Feedback Loop Drives Cholangiocarcinoma and Determines Response to CDK4/6 Inhibition.

Newsemia
Related Articles A Runaway PRH/HHEX-Notch3-Positive Feedback Loop Drives Cholangiocarcinoma and Determines Response to CDK4/6 Inhibition. Cancer Res. 2020 02 15;80(4):757-770 Authors: Kitchen P, Lee KY,...

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