Tag : pharmacokinetic

Pharma / Biotech

Role of rutin nanoemulsion in ameliorating oxidative stress: Pharmacokinetic and Pharmacodynamics studies.

Newsemia
Related Articles Role of rutin nanoemulsion in ameliorating oxidative stress: Pharmacokinetic and Pharmacodynamics studies. Chem Phys Lipids. 2020 Feb 04;:104890 Authors: Sharma S, Rabbani SA,...
Gastroenterology

P065 CHARACTERIZATION OF EARLY CLINICAL AND PHARMACOKINETIC RESPONSE PROFILES OF VEDOLIZUMAB: AN INTERIM ANALYSIS OF ENTERPRET, A PHASE 4 CLINICAL STUDY

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Vedolizumab (VDZ), a gut-selective antibody that binds specifically to integrin α4β7, is approved for treatment of adults with moderate-to-severe ulcerative colitis (UC). An association between...
Pharma / Biotech

Factor Xa inhibitors in clinical practice: Comparison of pharmacokinetic profiles.

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Related Articles Factor Xa inhibitors in clinical practice: Comparison of pharmacokinetic profiles. Drug Metab Pharmacokinet. 2019 Oct 25;: Authors: Goto E, Horinaka S, Ishimitsu T,...
Pharma / Biotech

Preclinical pharmacokinetic, biodistribution, radiation dosimetry, and toxicity studies of 99mTc-HYNIC-(Ser)3-LTVPWY: A novel HER2-targeted peptide radiotracer.

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Related Articles Preclinical pharmacokinetic, biodistribution, radiation dosimetry, and toxicity studies of 99mTc-HYNIC-(Ser)3-LTVPWY: A novel HER2-targeted peptide radiotracer. Regul Toxicol Pharmacol. 2020 Jan 29;:104591 Authors: Ardakani...
Pharma / Biotech

A randomized phase I pharmacokinetic trial comparing the potential biosimilar adalimumab (CinnoRA®) with the reference product (Humira®) in healthy volunteers.

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Related Articles A randomized phase I pharmacokinetic trial comparing the potential biosimilar adalimumab (CinnoRA®) with the reference product (Humira®) in healthy volunteers. Expert Opin Investig...
Pharma / Biotech

Pharmacokinetics, Pharmacodynamics and Dermal Distribution of 5-Methoxypsoralen Based on a Physiologically Based Pharmacokinetic Model to Support Phytotherapy Using Brosimum gaudichaudii.

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Related Articles Pharmacokinetics, Pharmacodynamics and Dermal Distribution of 5-Methoxypsoralen Based on a Physiologically Based Pharmacokinetic Model to Support Phytotherapy Using Brosimum gaudichaudii. Planta Med. 2020...
Pharma / Biotech

A multilevel object-oriented modelling methodology for physiologically-based pharmacokinetics (PBPK): Evaluation with a semi-mechanistic pharmacokinetic model.

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A multilevel object-oriented modelling methodology for physiologically-based pharmacokinetics (PBPK): Evaluation with a semi-mechanistic pharmacokinetic model. Comput Methods Programs Biomed. 2020 Jan 09;189:105322 Authors: Reig-Lopez J,...
Pharma / Biotech

Pharmacokinetic and pharmacodynamic of the cognitive enhancer modafinil: Relevant clinical and forensic aspects.

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Related Articles Pharmacokinetic and pharmacodynamic of the cognitive enhancer modafinil: Relevant clinical and forensic aspects. Subst Abus. 2020 Jan 17;:1-19 Authors: Sousa A, Dinis-Oliveira RJ...
Pharma / Biotech

Physiologically based pharmacokinetic modelling of oxycodone drug-drug interactions.

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Related Articles Physiologically based pharmacokinetic modelling of oxycodone drug-drug interactions. Biopharm Drug Dispos. 2020 Jan 10;: Authors: Rytkönen J, Ranta VP, Kokki M, Kokki H,...
Pharma / Biotech

Liquid chromatography-tandem mass spectrometry bioanalytical method for the determination of kavain in mice plasma: Application to a pharmacokinetic study.

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Related Articles Liquid chromatography-tandem mass spectrometry bioanalytical method for the determination of kavain in mice plasma: Application to a pharmacokinetic study. J Chromatogr B Analyt...
Pharma / Biotech

A rapid and sensitive UHPLC-MS/MS method for the determination of ziyuglycoside I and its application in a preliminary pharmacokinetic study in healthy and leukopenic rats.

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A rapid and sensitive UHPLC-MS/MS method for the determination of ziyuglycoside I and its application in a preliminary pharmacokinetic study in healthy and leukopenic rats....
Pharma / Biotech

Prediction of dolutegravir pharmacokinetics and dose optimization in neonates via physiologically based pharmacokinetic (PBPK) modelling.

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Related Articles Prediction of dolutegravir pharmacokinetics and dose optimization in neonates via physiologically based pharmacokinetic (PBPK) modelling. J Antimicrob Chemother. 2019 Dec 20;: Authors: Bunglawala...
Pharma / Biotech

Rubusoside-assisted solubilization of poorly soluble C6-Ceramide for a pilot pharmacokinetic study.

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Related Articles Rubusoside-assisted solubilization of poorly soluble C6-Ceramide for a pilot pharmacokinetic study. Prostaglandins Other Lipid Mediat. 2019 Dec 10;:106402 Authors: Chen J, Khiste SK,...
Pharma / Biotech

Bioactive indanes: Development and validation of an LC-MS/MS bioanalytical method for the determination of PH46A, a new potential anti-inflammatory agent, in dog and rat plasma and its application to a pharmacokinetic study in dog.

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Related Articles Bioactive indanes: Development and validation of an LC-MS/MS bioanalytical method for the determination of PH46A, a new potential anti-inflammatory agent, in dog and...
Pharma / Biotech

Dotinurad: a clinical pharmacokinetic study of a novel, selective urate reabsorption inhibitor in subjects with hepatic impairment.

Newsemia
Related Articles Dotinurad: a clinical pharmacokinetic study of a novel, selective urate reabsorption inhibitor in subjects with hepatic impairment. Clin Exp Nephrol. 2019 Nov 23;:...
Pharma / Biotech

Population Pharmacokinetic Modeling of Plasma Δ9 -tetrahydrocannabinol and an Active and Inactive Metabolite Following Controlled Smoked Cannabis Administration.

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Related Articles Population Pharmacokinetic Modeling of Plasma Δ9 -tetrahydrocannabinol and an Active and Inactive Metabolite Following Controlled Smoked Cannabis Administration. Br J Clin Pharmacol. 2019...
Pharma / Biotech

Oral delivery of lycopene-loaded microemulsion for brain-targeting: preparation, characterization, pharmacokinetic evaluation and tissue distribution.

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Related Articles Oral delivery of lycopene-loaded microemulsion for brain-targeting: preparation, characterization, pharmacokinetic evaluation and tissue distribution. Drug Deliv. 2019 Dec;26(1):1191-1205 Authors: Guo Y, Mao X,...
Pharma / Biotech

Use of a physiologically-based pharmacokinetic model to explore the potential disparity in nicotine disposition between adult and adolescent nonhuman primates.

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Related Articles Use of a physiologically-based pharmacokinetic model to explore the potential disparity in nicotine disposition between adult and adolescent nonhuman primates. Toxicol Appl Pharmacol....
Pharma / Biotech

Population pharmacokinetic model of Vancomycin based on therapeutic drug monitoring data in critically ill septic patients.

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Related Articles Population pharmacokinetic model of Vancomycin based on therapeutic drug monitoring data in critically ill septic patients. J Crit Care. 2019 Nov 05;55:116-121 Authors:...

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