Tag: Mutations

Gastroenterology

Undifferentiated carcinoma with osteoclast-like giant cells of the pancreas harboring KRAS and BRCA mutations: case report and whole exome sequencing analysis

Newsemia
Undifferentiated carcinoma with osteoclast-like giant cells (UC-OGC) is an extremely uncommon pancreatic neoplasm that comprises less than 1% of all exocrine pancreatic tumors. To date,...
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Coronavirus Becoming More Dangerous Despite Not Mutating, WHO Says

Newsemia
According to a new update from the World Health Organization, the coronavirus behind the pandemic isn’t mutating to become more dangerous. However, that doesn’t make...
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Many cells in human uterus carry 'cancer-driving' mutations that arise early in life

Newsemia
Many cells in the inner lining of the uterus carry ‘cancer-driving’ mutations that frequently arise early in life, report scientists from the Wellcome Sanger Institute,...
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Plasma monitoring of EGFR mutations in NSCLC may help predict resistance to tyrosine kinase inhibitors

Newsemia
Oncotarget Volume 11, Issue 11 reported that at clinical progression, 64 EGFR T790M plasma positive patients were subjected to second line-treatment with osimertinib and strictly...
AI/ML

Predicting the impacts of mutations on protein-ligand binding affinity based on molecular dynamics simulations and machine learning methods.

Newsemia
Related Articles Predicting the impacts of mutations on protein-ligand binding affinity based on molecular dynamics simulations and machine learning methods. Comput Struct Biotechnol J. 2020;18:439-454...
Gastroenterology

Commonly observed RNF43 mutations retain functionality in attenuating Wnt/β-catenin signaling and unlikely confer Wnt-dependency onto colorectal cancers

Newsemia
Commonly observed RNF43 mutations retain functionality in attenuating Wnt/β-catenin signaling and unlikely confer Wnt-dependency onto colorectal cancers Source link...
Neurology

Scientists reveal ability to reverse Huntington's disease-causing DNA repeat mutations in the lab

Newsemia
Neurodegenerative diseases, like Huntington’s disease and myotonic dystrophy, are often referred to as DNA repeat diseases, named because of long repeated sequences in the DNA...

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