Mutations

Targeting EGFR exon 20 insertion mutations in non-small cell lung cancer

The post Targeting EGFR exon 20 insertion mutations in non-small cell lung cancer appeared first on Biochemistry Blog: Biochemistry Help. Source link

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Gene mutations may match patients to pancreatic cancer treatments

[ad_1] Researchers from the University of Pittsburg Medical Center have found specific genetic mutations that revealed which pancreatic cancer tumors could be susceptible to existing chemotherapy drugs, according to an...

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Mutations May Help Target Pancreatic Cancer Tx

[ad_1] (MedPage Today) -- Gene alterations could make tumors vulnerable to agents used for other cancers Source link [ad_1]

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CRISPR base editing, known for precision, hits a snag with off-target mutations

[ad_1] The version of CRISPR whose selling point has been its precision suffers, ironically, from the same shortcoming that has dogged other forms of the genome editor — that it...

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Gene mutations linked to pancreatic cancer development

[ad_1] Inherited genetic mutations may increase the risk for pancreatic cancer in patients with specific pancreatic lesions, according to data published in Gastroenterology.Nicholas Roberts, PhD, of the department of pathology...

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Prognostic impact of ATM mutations in patients with metastatic colorectal cancer

[ad_1] Prognostic impact of ATM mutations in patients with metastatic colorectal cancer Source link [ad_1]

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BRAF V600E and SRC mutations as molecular markers for predicting prognosis and conversion surgery in Stage IV colorectal cancer

[ad_1] BRAF V600E and SRC mutations as molecular markers for predicting prognosis and conversion surgery in Stage IV colorectal cancer Source link [ad_1]

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Somatic mutations of PREX2 gene in patients with hepatocellular carcinoma

[ad_1] Somatic mutations of PREX2 gene in patients with hepatocellular carcinoma Source link [ad_1]

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Mutations in Hepatitis D Virus Allow it to Escape Detection by CD8+ T Cells and Evolve at the Population Level

[ad_1] Hepatitis D virus (HDV) super-infection in patients with hepatitis B virus (HBV) is associated with rapid progression to liver cirrhosis and hepatocellular carcinoma. Treatment options are limited, and no...

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Sudden death in mild hypertrophic cardiomyopathy with compound DSG2/DSC2/MYH6 mutations: Revisiting phenotype after genetic assessment in a master runner athlete.

[ad_1] Related Articles Sudden death in mild hypertrophic cardiomyopathy with compound DSG2/DSC2/MYH6 mutations: Revisiting phenotype after genetic assessment in a master runner athlete. J Electrocardiol. 2019 Jan 02;53:95-99 Authors: Castellana...

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Mapping mutations in esophageal cancer could improve treatment options

[ad_1] Mutations that cause oesophageal adenocarcinoma have been mapped in unprecedented detail - unveiling that more than half could be targeted by drugs currently in trials for other cancer types....

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Prevalence of Germline Mutations Associated with Cancer Risk in Patients With Intraductal Papillary Mucinous Neoplasms

[ad_1] Many patients with pancreatic adenocarcinoma (PDAC) carry germline mutations associated with increased risk of cancer. It is not clear whether patients with intraductal papillary mucinous neoplasms (IPMNs), which are...

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Response to: An immunohistochemical approach to detect oncogenic CTNNB1 mutations in primary neoplastic tissues

[ad_1] Response to: An immunohistochemical approach to detect oncogenic CTNNB1 mutations in primary neoplastic tissues Source link [ad_1]

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Interferon regulatory factor 6 mutations implicated in neural tube defects, including spina bifida

[ad_1] Mutations in a gene known as interferon regulatory factor 6 that cause cleft lip and palate also are implicated in neural tube defects such as spina bifida, suggests new...

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Chewing induced reflex seizures ("eating epilepsy") and eye closure sensitivity as a common feature in pediatric patients with SYNGAP1 mutations: Review of literature and report of 8 cases.

[ad_1] Related Articles Chewing induced reflex seizures ("eating epilepsy") and eye closure sensitivity as a common feature in pediatric patients with SYNGAP1 mutations: Review of literature and report of 8...

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Environment-dependent pleiotropic effects of mutations on the maximum growth rate <i>r</i> and carrying capacity <i>K</i> of population growth

[ad_1] by Xinzhu Wei, Jianzhi Zhang Maximum growth rate per individual (r) and carrying capacity (K) are key life-history traits that together characterize the density-dependent population growth and therefore are...

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SMuRF: Portable and accurate ensemble prediction of somatic mutations.

[ad_1] SMuRF: Portable and accurate ensemble prediction of somatic mutations. Bioinformatics. 2019 Jan 12;: Authors: Huang W, Guo YA, Muthukumar K, Baruah P, Chang MM, Skanderup AJ Abstract Summary: Somatic...

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Safety, Tolerability, and Pharmacokinetics of Single Ascending Doses of ELX-02, a Potential Treatment for Genetic Disorders Caused by Nonsense Mutations, in Healthy Volunteers.

[ad_1] Related Articles Safety, Tolerability, and Pharmacokinetics of Single Ascending Doses of ELX-02, a Potential Treatment for Genetic Disorders Caused by Nonsense Mutations, in Healthy Volunteers. Clin Pharmacol Drug Dev....

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Old Tissues Have Many Mutations, Even Absent Cancer

[ad_1] Cancer is the result of random mutational damage to nuclear DNA, but most such damage has no real effect, not even to the behavior of the affected cell. Cells...

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Rare mutations of ADAM17 from TOFs induce hypertrophy in human embryonic stem cell-derived cardiomyocytes via HB-EGF signaling.

[ad_1] Related Articles Rare mutations of ADAM17 from TOFs induce hypertrophy in human embryonic stem cell-derived cardiomyocytes via HB-EGF signaling. Clin Sci (Lond). 2019 Jan 04;: Authors: Xie Y, Ma...

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