Tag : mutant

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HER2-mediated internalization of cytotoxic agents in ERBB2 amplified or mutant lung cancers

Newsemia
Li, BT; Michelini, F; Misale, S; Cocco, E; Baldino, L; Cai, Y; Shifman, S; … Scaltriti, M; + view all Li, BT; Michelini, F; Misale,...
Gastroenterology

P152 EVALUATING THE EFFICACY OF GLUTAMATE CARBOXYPEPTIDASE II (GCPII) INHIBITORS IN “WILD-TYPE” MICE: LESSONS LEARNED FROM THE DEDICATOR OF CYTOKINESIS 2 MUTANT MOUSE

Newsemia
Glutamate carboxypeptidase II (GCPII) is highly upregulated in human IBD and is a therapeutic target under active investigation by our laboratory. We recently published that...
Pharma / Biotech

Establishment of the experimental procedure for prediction of conjugation capacity in mutant UGT1A1.

Newsemia
Related Articles Establishment of the experimental procedure for prediction of conjugation capacity in mutant UGT1A1. PLoS One. 2019;14(11):e0225244 Authors: Takaoka Y, Takeuchi A, Sugano A,...
Biology

Correction of Glycogen Synthase Kinase 3{beta} in Myotonic Dystrophy 1 Reduces the Mutant RNA and Improves Postnatal Survival of DMSXL Mice [Research Article]

Newsemia
Myotonic dystrophy type 1 (DM1) is a multisystem neuromuscular disease without cure. One of the possible therapeutic approaches for DM1 is correction of the RNA-binding...
Biology

Targeting oxidative pentose phosphate pathway prevents recurrence in mutant <i>Kras</i> colorectal carcinomas

Newsemia
by WenChao Gao, YuTing Xu, Tao Chen, ZunGuo Du, XiuJuan Liu, ZhiQian Hu, Dong Wei, ChunFang Gao, Wei Zhang, QingQuan Li Recurrent tumors originate from...
Neurology

Rational design of linear tripeptides against the aggregation of human mutant SOD1 protein causing amyotrophic lateral sclerosis

Newsemia
Formation of protein aggregation is considered a hallmark feature of various neurological diseases. Amyotrophic lateral sclerosis is one such devastating neurodegenerative disorder characterized by mutation...
Biology

The Second Site Modifier, Sympathy for the ligule, Encodes a Homolog of Arabidopsis ENHANCED DISEASE RESISTANCE4 and Rescues the Liguleless narrow Maize Mutant

Newsemia
Liguleless narrow1 encodes a plasma membrane-localized receptor-like kinase required for normal development of maize (Zea mays) leaves, internodes, and inflorescences. The semidominant Lgn-R mutation lacks...

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