Tag : mouse

Gastroenterology

7 LACTOBACILLUS REUTERI SUPPRESSES PRO-INFLAMMATORY DRIVEN REACTIVE OXYGEN SPECIES IN VITRO IN HUMAN INTESTINAL EPITHELIAL CELLS AND IN VIVO IN A TNBS COLITIS MOUSE MODEL

Newsemia
Reactive oxygen species (ROS) play a role in maintaining intestinal epithelial homeostasis and are normally kept at low levels via antioxidant compounds. Dysregulation of ROS...
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Characterizing embryonic gene expression patterns in the mouse using nonredundant sequence-based selection

Newsemia
Sousa-Nunes, R; Rana, AA; Kettleborough, R; Brickman, JM; Clements, M; Forrest, A; Grimmond, S; … Beddington, RS; + view all Sousa-Nunes, R; Rana, AA; Kettleborough,...
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T1 Mapping Detects Pharmacological Retardation of Diffuse Cardiac Fibrosis in Mouse Pressure-Overload Hypertrophy

Newsemia
Stuckey, DJ; McSweeney, SJ; Thin, MZ; Habib, J; Price, AN; Fiedler, LR; Gsell, W; … Schneider, MD; + view all Stuckey, DJ; McSweeney, SJ; Thin,...
Gastroenterology

6 NOVEL BRD4 INHIBITORS BLOCK THE PATHOLOGICAL ACTIVATION OF BRD4-NFκB SIGNALING AND SUPPRESS COLONIC INFLAMMATION IN IBD MOUSE MODELS

Newsemia
Ulcerative Colitis (UC) and Crohn’s Disease (CD) are two major types of inflammatory bowel disease (IBD), with recurrent symptoms and significant morbidity. Long-term persistence of...
Gastroenterology

P152 EVALUATING THE EFFICACY OF GLUTAMATE CARBOXYPEPTIDASE II (GCPII) INHIBITORS IN “WILD-TYPE” MICE: LESSONS LEARNED FROM THE DEDICATOR OF CYTOKINESIS 2 MUTANT MOUSE

Newsemia
Glutamate carboxypeptidase II (GCPII) is highly upregulated in human IBD and is a therapeutic target under active investigation by our laboratory. We recently published that...
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Systemic AAV9 gene therapy using the synapsin I promoter rescues a mouse model of neuronopathic Gaucher disease but with limited cross-correction potential to astrocytes

Newsemia
Massaro, G; Hughes, MP; Whaler, SM; Wallom, K-L; Priestman, DA; Platt, FM; Waddington, SN; Massaro, G; Hughes, MP; Whaler, SM; Wallom, K-L; Priestman, DA; Platt,...
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Cervical gene delivery of the antimicrobial peptide, Human β‐defensin (HBD)-3, in a mouse model of ascending infection-related preterm birth

Newsemia
Suff, N; Rajvinder, K; Diaz, A; Ng, J; Baruteau, J; Perocheau, D; Taylor, P; … Peebles, DM; + view all Suff, N; Rajvinder, K; Diaz,...

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