Tag: Mouse models

Biology

Spontaneous generation of prions and transmissible PrP amyloid in a humanised transgenic mouse model of A117V GSS

Newsemia
by Emmanuel A. Asante, Jacqueline M. Linehan, Andrew Tomlinson, Tatiana Jakubcova, Shyma Hamdan, Andrew Grimshaw, Michelle Smidak, Asif Jeelani, Akin Nihat, Simon Mead, Sebastian Brandner,...
Biology

Ten tips for a text-mining-ready article: How to improve automated discoverability and interpretability

Newsemia
by Robert Leaman, Chih-Hsuan Wei, Alexis Allot, Zhiyong Lu Data-driven research in biomedical science requires structured, computable data. Increasingly, these data are created with support...
Biology

Neuronal activity triggers uptake of hematopoietic extracellular vesicles in vivo

Newsemia
by Ivan-Maximiliano Kur, Pierre-Hugues Prouvot, Ting Fu, Wei Fan, Felicia Müller-Braun, Avash Das, Saumya Das, Thomas Deller, Jochen Roeper, Albrecht Stroh, Stefan Momma Communication with...
Biology

Maternal obesity-induced endoplasmic reticulum stress causes metabolic alterations and abnormal hypothalamic development in the offspring

Newsemia
by Soyoung Park, Alice Jang, Sebastien G. Bouret The steady increase in the prevalence of obesity and associated type II diabetes mellitus is a major...
Biology

Pancreatic β cell microRNA-26a alleviates type 2 diabetes by improving peripheral insulin sensitivity and preserving β cell function

Newsemia
by Haixia Xu, Xiao Du, Jia Xu, Yu Zhang, Yan Tian, Geng Liu, Xiuxuan Wang, Meilin Ma, Wenya Du, Yu Liu, Lunzhi Dai, Wendong Huang,...
Biology

Lack of the MHC class II chaperone H2-O causes susceptibility to autoimmune diseases

Newsemia
by Robin A. Welsh, Nianbin Song, Catherine A. Foss, Tatiana Boronina, Robert N. Cole, Scheherazade Sadegh-Nasseri DO (HLA-DO, in human; murine H2-O) is a highly...
Biology

Barrel cortex VIP/ChAT interneurons suppress sensory responses in vivo

Newsemia
by Amir Dudai, Nadav Yayon, Vitaly Lerner, Gen-ichi Tasaka, Yair Deitcher, Karin Gorfine, Naomi Niederhoffer, Adi Mizrahi, Hermona Soreq, Michael London Cortical interneurons expressing vasoactive...
Biology

SK2 channels in cerebellar Purkinje cells contribute to excitability modulation in motor-learning–specific memory traces

Newsemia
by Giorgio Grasselli, Henk-Jan Boele, Heather K. Titley, Nora Bradford, Lisa van Beers, Lindsey Jay, Gerco C. Beekhof, Silas E. Busch, Chris I. de Zeeuw,...
Biology

The deubiquitinase USP6 affects memory and synaptic plasticity through modulating NMDA receptor stability

Newsemia
by Fanwei Zeng, Xuehai Ma, Lin Zhu, Qiang Xu, Yuzhe Zeng, Yue Gao, Guilin Li, Tiantian Guo, Haibin Zhang, Xiaoyan Tang, Ziqiang Wang, Zesen Ye,...
Biology

Loss of adenomatous polyposis coli function renders intestinal epithelial cells resistant to the cytokine IL-22

Newsemia
by Yu Chen, Maud Vandereyken, Ian P. Newton, Ignacio Moraga, Inke S. Näthke, Mahima Swamy Interleukin-22 (IL-22) is a critical immune defence cytokine that maintains...
Biology

NLRX1 inhibits the early stages of CNS inflammation and prevents the onset of spontaneous autoimmunity

Newsemia
by Marjan Gharagozloo, Shaimaa Mahmoud, Camille Simard, Kenzo Yamamoto, Diwakar Bobbala, Subburaj Ilangumaran, Matthew D. Smith, Albert Lamontagne, Samir Jarjoura, Jean-Bernard Denault, Véronique Blais, Louis...
Biology

MCC950/CRID3 potently targets the NACHT domain of wild-type NLRP3 but not disease-associated mutants for inflammasome inhibition

Newsemia
by Lieselotte Vande Walle, Irma B. Stowe, Pavel Šácha, Bettina L. Lee, Dieter Demon, Amelie Fossoul, Filip Van Hauwermeiren, Pedro H. V. Saavedra, Petr Šimon,...
Biology

Activation of the intrinsic fibroinflammatory program in adult pancreatic acinar cells triggered by Hippo signaling disruption

Newsemia
by Jun Liu, Ming Gao, Michael Nipper, Janice Deng, Francis E. Sharkey, Randy L. Johnson, Howard C. Crawford, Yidong Chen, Pei Wang Damaged acinar cells...
Biology

Nystagmus in patients with congenital stationary night blindness (CSNB) originates from synchronously firing retinal ganglion cells

Newsemia
by Beerend H. J. Winkelman, Marcus H. C. Howlett, Maj-Britt Hölzel, Coen Joling, Kathryn H. Fransen, Gobinda Pangeni, Sander Kamermans, Hiraki Sakuta, Masaharu Noda, Huibert...
Biology

Adult bone marrow progenitors become decidual cells and contribute to embryo implantation and pregnancy

Newsemia
by Reshef Tal, Shafiq Shaikh, Pallavi Pallavi, Aya Tal, Francesc López-Giráldez, Fang Lyu, Yuan-Yuan Fang, Shruti Chinchanikar, Ying Liu, Harvey J. Kliman, Myles Alderman III,...
Biology

Loss of Bardet-Biedl syndrome proteins causes synaptic aberrations in principal neurons

Newsemia
by Naila Haq, Christoph Schmidt-Hieber, Fernando J. Sialana, Lorenza Ciani, Janosch P. Heller, Michelle Stewart, Liz Bentley, Sara Wells, Richard J. Rodenburg, Patrick M. Nolan,...

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