Tag : Mouse models

Biology

Pancreatic β cell microRNA-26a alleviates type 2 diabetes by improving peripheral insulin sensitivity and preserving β cell function

Newsemia
by Haixia Xu, Xiao Du, Jia Xu, Yu Zhang, Yan Tian, Geng Liu, Xiuxuan Wang, Meilin Ma, Wenya Du, Yu Liu, Lunzhi Dai, Wendong Huang,...
Biology

Lack of the MHC class II chaperone H2-O causes susceptibility to autoimmune diseases

Newsemia
by Robin A. Welsh, Nianbin Song, Catherine A. Foss, Tatiana Boronina, Robert N. Cole, Scheherazade Sadegh-Nasseri DO (HLA-DO, in human; murine H2-O) is a highly...
Biology

Barrel cortex VIP/ChAT interneurons suppress sensory responses in vivo

Newsemia
by Amir Dudai, Nadav Yayon, Vitaly Lerner, Gen-ichi Tasaka, Yair Deitcher, Karin Gorfine, Naomi Niederhoffer, Adi Mizrahi, Hermona Soreq, Michael London Cortical interneurons expressing vasoactive...
Biology

SK2 channels in cerebellar Purkinje cells contribute to excitability modulation in motor-learning–specific memory traces

Newsemia
by Giorgio Grasselli, Henk-Jan Boele, Heather K. Titley, Nora Bradford, Lisa van Beers, Lindsey Jay, Gerco C. Beekhof, Silas E. Busch, Chris I. de Zeeuw,...
Biology

The deubiquitinase USP6 affects memory and synaptic plasticity through modulating NMDA receptor stability

Newsemia
by Fanwei Zeng, Xuehai Ma, Lin Zhu, Qiang Xu, Yuzhe Zeng, Yue Gao, Guilin Li, Tiantian Guo, Haibin Zhang, Xiaoyan Tang, Ziqiang Wang, Zesen Ye,...
Biology

Loss of adenomatous polyposis coli function renders intestinal epithelial cells resistant to the cytokine IL-22

Newsemia
by Yu Chen, Maud Vandereyken, Ian P. Newton, Ignacio Moraga, Inke S. Näthke, Mahima Swamy Interleukin-22 (IL-22) is a critical immune defence cytokine that maintains...
Biology

NLRX1 inhibits the early stages of CNS inflammation and prevents the onset of spontaneous autoimmunity

Newsemia
by Marjan Gharagozloo, Shaimaa Mahmoud, Camille Simard, Kenzo Yamamoto, Diwakar Bobbala, Subburaj Ilangumaran, Matthew D. Smith, Albert Lamontagne, Samir Jarjoura, Jean-Bernard Denault, Véronique Blais, Louis...
Biology

MCC950/CRID3 potently targets the NACHT domain of wild-type NLRP3 but not disease-associated mutants for inflammasome inhibition

Newsemia
by Lieselotte Vande Walle, Irma B. Stowe, Pavel Šácha, Bettina L. Lee, Dieter Demon, Amelie Fossoul, Filip Van Hauwermeiren, Pedro H. V. Saavedra, Petr Šimon,...
Biology

Activation of the intrinsic fibroinflammatory program in adult pancreatic acinar cells triggered by Hippo signaling disruption

Newsemia
by Jun Liu, Ming Gao, Michael Nipper, Janice Deng, Francis E. Sharkey, Randy L. Johnson, Howard C. Crawford, Yidong Chen, Pei Wang Damaged acinar cells...
Biology

Nystagmus in patients with congenital stationary night blindness (CSNB) originates from synchronously firing retinal ganglion cells

Newsemia
by Beerend H. J. Winkelman, Marcus H. C. Howlett, Maj-Britt Hölzel, Coen Joling, Kathryn H. Fransen, Gobinda Pangeni, Sander Kamermans, Hiraki Sakuta, Masaharu Noda, Huibert...
Biology

Adult bone marrow progenitors become decidual cells and contribute to embryo implantation and pregnancy

Newsemia
by Reshef Tal, Shafiq Shaikh, Pallavi Pallavi, Aya Tal, Francesc López-Giráldez, Fang Lyu, Yuan-Yuan Fang, Shruti Chinchanikar, Ying Liu, Harvey J. Kliman, Myles Alderman III,...
Biology

Loss of Bardet-Biedl syndrome proteins causes synaptic aberrations in principal neurons

Newsemia
by Naila Haq, Christoph Schmidt-Hieber, Fernando J. Sialana, Lorenza Ciani, Janosch P. Heller, Michelle Stewart, Liz Bentley, Sara Wells, Richard J. Rodenburg, Patrick M. Nolan,...
Biology

Nesting box imager: Contact-free, real-time measurement of activity, surface body temperature, and respiratory rate applied to hibernating mouse models

Newsemia
by Nathaniel E. Kallmyer, Han Jong Shin, Ethan A. Brem, William J. Israelsen, Nigel F. Reuel Noncontact methods to measure animal activity and physiology are...
Biology

Attenuation of chronic antiviral T-cell responses through constitutive COX2-dependent prostanoid synthesis by lymph node fibroblasts

Newsemia
by Karin Schaeuble, Hélène Cannelle, Stéphanie Favre, Hsin-Ying Huang, Susanne G. Oberle, Daniel E. Speiser, Dietmar Zehn, Sanjiv A. Luther Lymphoid T-zone fibroblastic reticular cells...
Biology

Targeted genetic screening in mice through haploid embryonic stem cells identifies critical genes in bone development

Newsemia
by Meizhu Bai, Yujiao Han, Yuxuan Wu, Jiaoyang Liao, Lin Li, Lijun Wang, Qing Li, Wenhui Xing, Luonan Chen, Weiguo Zou, Jinsong Li Mutagenic screening...
Biology

Complement alone drives efficacy of a chimeric antigonococcal monoclonal antibody

Newsemia
by Sunita Gulati, Frank J. Beurskens, Bart-Jan de Kreuk, Marcel Roza, Bo Zheng, Rosane B. DeOliveira, Jutamas Shaughnessy, Nancy A. Nowak, Ronald P. Taylor, Marina...
Biology

Correction: Lipoprotein Receptor LRP1 Regulates Leptin Signaling and Energy Homeostasis in the Adult Central Nervous System

Newsemia
by Qiang Liu, Juan Zhang, Celina Zerbinatti, Yan Zhan, Benedict J. Kolber, Joachim Herz, Louis J. Muglia, Guojun Bu Source link...

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