Tag: Motor Neurons

Biology

A widespread family of heat-resistant obscure (Hero) proteins protect against protein instability and aggregation

Newsemia
by Kotaro Tsuboyama, Tatsuya Osaki, Eriko Matsuura-Suzuki, Hiroko Kozuka-Hata, Yuki Okada, Masaaki Oyama, Yoshiho Ikeuchi, Shintaro Iwasaki, Yukihide Tomari Proteins are typically denatured and aggregated...
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Injection approach to deliver gene-silencing vector effectively blocks ALS progression

Newsemia
Writing in Nature Medicine, an international team headed by researchers at University of California San Diego School of Medicine describe a new way to effectively...
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Some plant foods causing paralysis, death, in malnourished populations

Newsemia
There are a lot of plants eaten for food that may also contain toxins that harm the brain and the nervous system, when present in...
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Northwestern scientists receive $3.1 million grant to investigate drug therapies for ALS

Newsemia
Two Northwestern University scientists have received a $3.1 million grant from the National Institute on Aging to collaborate and investigate drug therapies for amyotrophic lateral...
Biology

Glutamatergic neurons of the gigantocellular reticular nucleus shape locomotor pattern and rhythm in the freely behaving mouse

Newsemia
by Maxime Lemieux, Frederic Bretzner Because of their intermediate position between supraspinal locomotor centers and spinal circuits, gigantocellular reticular nucleus (GRN) neurons play a key...
Biology

Trpm4 ion channels in pre-Bötzinger complex interneurons are essential for breathing motor pattern but not rhythm

Newsemia
by Maria Cristina D. Picardo, Yae K. Sugimura, Kaitlyn E. Dorst, Prajkta S. Kallurkar, Victoria T. Akins, Xingru Ma, Ryoichi Teruyama, Romain Guinamard, Kaiwen Kam,...
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Study points to potential new biomarker and drug target for amyotrophic lateral sclerosis

Newsemia
Research led by stem cell scientists at Harvard University points to a potential new biomarker and drug target for amyotrophic lateral sclerosis, a neurological disease...
Neurology

Ezogabine treatment reduces motor neuron excitability in ALS patients, study shows

Newsemia
Brian Wainger, MD, PhD, of the Healey Center for ALS at Massachusetts General Hospital presented initial, top-level results of a recently completed phase 2 clinical...
Biology

Multimodal sensory information is represented by a combinatorial code in a sensorimotor system

Newsemia
by Rosangela Follmann, Christopher John Goldsmith, Wolfgang Stein A ubiquitous feature of the nervous system is the processing of simultaneously arriving sensory inputs from different...
Neurology

Study shows that rogue proteins may underlie some ALS and frontotemporal dementia cases

Newsemia
ALS — amyotrophic lateral sclerosis — is a neurodegenerative disease that attacks motor neurons in the brain and spinal cord, slowly robbing its victims of...
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Alternative method identified for delivering nusinersen to spinal muscular atrophy patients

Newsemia
A new report has identified an alternative method to deliver nusinersen to patients with spinal muscular atrophy using a subcutaneous intrathecal catheter system configured by...

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