Tag: molecule

Pharma / Biotech

Small Molecule Dysregulation of TEAD Lipidation Induces a Dominant-Negative Inhibition of Hippo Pathway Signaling.

Newsemia
Related Articles Small Molecule Dysregulation of TEAD Lipidation Induces a Dominant-Negative Inhibition of Hippo Pathway Signaling. Cell Rep. 2020 Jun 23;31(12):107809 Authors: Holden JK, Crawford...
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Direct structural link between SARS-CoV-2 and essential fatty acid

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Now, a new study published on the preprint server bioRxiv in June 2020 reports the discovery of a novel free fatty acid (FFA) binding pocket...
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Glycans "lock and load" the SARS-CoV-2 spike protein for infection

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A new study by scientists from the University of California San Diego, USA and Maynooth University, Ireland and published on the preprint server bioRxiv* in...
Neurology

Research provides new evidence for potential blood-based biomarker for Alzheimer's

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A potential blood-based biomarker for Alzheimer’s and other neurodegenerative diseases seems even more promising thanks to new research from a Massachusetts General Hospital-led study. Source...
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New strategy identified to address the underlying cause of LAD1 patients' symptoms

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Owing to a rare genetic mutation, individuals with leukocyte adhesion deficiency type 1 (LAD1) experience a suite of symptoms that trace back to an immune...
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Study uncovers cause of blood-vessel leakiness in eye diseases

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Scientists have identified a key step in the process that leads to leaky vessels and harmful swelling in eye diseases, according to a new study...
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New family of molecules to join altered receptors in Alzheimer's, Parkinson's and Huntington's

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An article published in the Journal of Medicinal Chemistry shows a new family of molecules with high affinity to join imidazoline receptors, which are altered...
Biology

A Redox-Sensitive Thiol in Wis1 Modulates the Fission Yeast Mitogen-Activated Protein Kinase Response to H2O2 and Is the Target of a Small Molecule [Research Article]

Newsemia
Oxidation of a highly conserved cysteine (Cys) residue located in the kinase activation loop of mitogen-activated protein kinase kinases (MAPKK) inactivates mammalian MKK6. This residue...

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