Tag : Molecular structure

Pharma / Biotech

C-terminal-modified LY2510924: a versatile scaffold for targeting C-X-C chemokine receptor type 4.

Newsemia
Related Articles C-terminal-modified LY2510924: a versatile scaffold for targeting C-X-C chemokine receptor type 4. Sci Rep. 2019 10 25;9(1):15284 Authors: Suzuki K, Ui T, Nagano...
Pharma / Biotech

Scaffold morphing of arbidol (umifenovir) in search of multi-targeting therapy halting the interaction of SARS-CoV-2 with ACE2 and other proteases involved in COVID-19.

Newsemia
Related Articles Scaffold morphing of arbidol (umifenovir) in search of multi-targeting therapy halting the interaction of SARS-CoV-2 with ACE2 and other proteases involved in COVID-19....
Pharma / Biotech

Novel spectrofluorimetric quantification of alogliptin benzoate in biofluids exploiting its interaction with 4-chloro-7-nitrobenzofurazan.

Newsemia
Related Articles Novel spectrofluorimetric quantification of alogliptin benzoate in biofluids exploiting its interaction with 4-chloro-7-nitrobenzofurazan. Luminescence. 2020 Mar;35(2):284-291 Authors: Aref HA, Hammad SF, Darwish KM,...
Dermatology

Interaction of C20-substituted derivative of pregnenolone acetate with copper (II) leads to ROS generation, DNA cleavage and apoptosis in cervical cancer cells: Therapeutic potential of copper chelation for cancer treatment.

Newsemia
Related Articles Interaction of C20-substituted derivative of pregnenolone acetate with copper (II) leads to ROS generation, DNA cleavage and apoptosis in cervical cancer cells: Therapeutic...
Pharma / Biotech

Multifunctional nanoparticles from albumin for stimuli-responsive efficient dual drug delivery.

Newsemia
Related Articles Multifunctional nanoparticles from albumin for stimuli-responsive efficient dual drug delivery. Bioorg Chem. 2019 07;88:102959 Authors: Nosrati H, Abhari F, Charmi J, Davaran S,...
Pharma / Biotech

Structure based design of macrocyclic factor XIa inhibitors: Discovery of cyclic P1 linker moieties with improved oral bioavailability.

Newsemia
Related Articles Structure based design of macrocyclic factor XIa inhibitors: Discovery of cyclic P1 linker moieties with improved oral bioavailability. Bioorg Med Chem Lett. 2019...
Pharma / Biotech

Discovery of novel pyridazine derivatives as glucose transporter type 4 (GLUT4) translocation activators.

Newsemia
Related Articles Discovery of novel pyridazine derivatives as glucose transporter type 4 (GLUT4) translocation activators. Bioorg Med Chem Lett. 2019 07 15;29(14):1785-1790 Authors: Tsuji T,...
Biology

Building de novo cryo-electron microscopy structures collaboratively with citizen scientists

Newsemia
by Firas Khatib, Ambroise Desfosses, Foldit Players , Brian Koepnick, Jeff Flatten, Zoran Popović, David Baker, Seth Cooper, Irina Gutsche, Scott Horowitz With the rapid...

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