Tag: metabolite

Pharma / Biotech

Systemic exposure to 5-Fluorouracil and its metabolite, 5,6-dihydrofluorouracil, and development of a limited sampling strategy for therapeutic drug management of 5-Fluorouracil in patients with gastrointestinal malignancy.

Newsemia
Related Articles Systemic exposure to 5-Fluorouracil and its metabolite, 5,6-dihydrofluorouracil, and development of a limited sampling strategy for therapeutic drug management of 5-Fluorouracil in patients...
Pharma / Biotech

Bioanalytical method for the simultaneous quantification of irinotecan and its active metabolite SN-38 in mouse plasma and tissue homogenates using HPLC-fluorescence.

Newsemia
Related Articles Bioanalytical method for the simultaneous quantification of irinotecan and its active metabolite SN-38 in mouse plasma and tissue homogenates using HPLC-fluorescence. J Chromatogr...
Pharma / Biotech

Metabolite Identification Using An Ion Mobility-Enhanced Data-Independent Acquisition Strategy and Automated Data Processing.

Newsemia
Related Articles Metabolite Identification Using An Ion Mobility-Enhanced Data-Independent Acquisition Strategy and Automated Data Processing. Rapid Commun Mass Spectrom. 2020 Mar 24;:e8792 Authors: Radchenko T,...
AI/ML

Deep learning-based target metabolite isolation and big data-driven measurement uncertainty estimation in proton magnetic resonance spectroscopy of the brain.

Newsemia
Related Articles Deep learning-based target metabolite isolation and big data-driven measurement uncertainty estimation in proton magnetic resonance spectroscopy of the brain. Magn Reson Med. 2020...
Gastroenterology

TMAVA, a Metabolite of Intestinal Microbes, Is Increased in Plasma From Patients With Liver Steatosis, Inhibits γ-butyrobetaine Hydroxylase, and Exacerbates Fatty Liver in Mice

Newsemia
The authors identified a metabolite produced by intestinal bacteria, TMAVA, that worsens fatty liver disease by reducing production of the amino acid carnitine. Carnitine might...
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Ulcerative colitis and a missing microbe in the gut

Newsemia
Ulcerative colitis is a seriously debilitating inflammatory disease of the bowel leading to crippling symptoms that can affect the quality of life severely. Researchers from...
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Scientists identify new biomarker for identifying individuals at risk of depression

Newsemia
Chronic pain, or inflammation, is believed to be one of the major factors in the onset of major depressive disorder. Source link...
Pharma / Biotech

Characterizing biopersistence potential of the metabolite 5:3 fluorotelomer carboxylic acid after repeated oral exposure to the 6:2 fluorotelomer alcohol.

Newsemia
Related Articles Characterizing biopersistence potential of the metabolite 5:3 fluorotelomer carboxylic acid after repeated oral exposure to the 6:2 fluorotelomer alcohol. Toxicol Appl Pharmacol. 2020...
Gastroenterology

Key mechanism identified for how antiviral immune responses reprogram liver metabolism

Newsemia
Researchers at the CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences identified a key mechanism for how antiviral immune responses reprogram...

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