Tag : metabolite

Pharma / Biotech

Metabolite profile comparisons between ascending and descending colon tissue in healthy adults.

Newsemia
Related Articles Metabolite profile comparisons between ascending and descending colon tissue in healthy adults. World J Gastroenterol. 2020 Jan 21;26(3):335-352 Authors: Baxter BA, Parker KD,...
Cardiology

Cardioprotective GLP-1 metabolite prevents ischemic cardiac injury by inhibiting mitochondrial trifunctional protein-α.

Newsemia
Related Articles Cardioprotective GLP-1 metabolite prevents ischemic cardiac injury by inhibiting mitochondrial trifunctional protein-α. J Clin Invest. 2020 03 02;130(3):1392-1404 Authors: Siraj MA, Mundil D,...
Pharma / Biotech

Population Pharmacokinetics of Esketamine Nasal Spray and its Metabolite Noresketamine in Healthy Subjects and Patients with Treatment-Resistant Depression.

Newsemia
Related Articles Population Pharmacokinetics of Esketamine Nasal Spray and its Metabolite Noresketamine in Healthy Subjects and Patients with Treatment-Resistant Depression. Clin Pharmacokinet. 2020 Oct 31;:...
AI/ML

Next-generation metabolic engineering approaches towards development of plant cell suspension cultures as specialized metabolite producing biofactories.

Newsemia
Related Articles Next-generation metabolic engineering approaches towards development of plant cell suspension cultures as specialized metabolite producing biofactories. Biotechnol Adv. 2020 Sep 22;:107635 Authors: Arya...
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Scientists investigate active plasma metabolite of remdesivir in SARS-CoV-2 mouse model

Newsemia
Using mouse models, scientists have investigated the active plasma metabolite of remdesivir, GS-441 524, and hydroxychloroquine as possible drug candidates in COVID-19. The research shows...
Cardiology

Heart Failure Disturbs Gut-Blood Barrier and Increases Plasma Trimethylamine, a Toxic Bacterial Metabolite.

Newsemia
Related Articles Heart Failure Disturbs Gut-Blood Barrier and Increases Plasma Trimethylamine, a Toxic Bacterial Metabolite. Int J Mol Sci. 2020 Aug 26;21(17): Authors: Drapala A,...
Neurology

Third Trimester Cerebellar Metabolite Concentrations are Decreased in Very Premature Infants with Structural Brain Injury.

Newsemia
Related Articles Third Trimester Cerebellar Metabolite Concentrations are Decreased in Very Premature Infants with Structural Brain Injury. Sci Rep. 2019 02 04;9(1):1212 Authors: Basu SK,...
Cardiology

A Cardiovascular Disease-Linked Gut Microbial Metabolite Acts via Adrenergic Receptors.

Newsemia
Related Articles A Cardiovascular Disease-Linked Gut Microbial Metabolite Acts via Adrenergic Receptors. Cell. 2020 03 05;180(5):862-877.e22 Authors: Nemet I, Saha PP, Gupta N, Zhu W,...
Neurology

Experimental therapy slows zika replication and prevents microcephaly in mice

Newsemia
An international group of researchers have discovered that inhibiting AHR (aryl hydrocarbon receptor), a protein with roles in regulating immunity, stem cell maintenance and cellular...
Pharma / Biotech

Systemic exposure to 5-Fluorouracil and its metabolite, 5,6-dihydrofluorouracil, and development of a limited sampling strategy for therapeutic drug management of 5-Fluorouracil in patients with gastrointestinal malignancy.

Newsemia
Related Articles Systemic exposure to 5-Fluorouracil and its metabolite, 5,6-dihydrofluorouracil, and development of a limited sampling strategy for therapeutic drug management of 5-Fluorouracil in patients...
Pharma / Biotech

Bioanalytical method for the simultaneous quantification of irinotecan and its active metabolite SN-38 in mouse plasma and tissue homogenates using HPLC-fluorescence.

Newsemia
Related Articles Bioanalytical method for the simultaneous quantification of irinotecan and its active metabolite SN-38 in mouse plasma and tissue homogenates using HPLC-fluorescence. J Chromatogr...

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