Tag: Membrane proteins

Biology

Optogenetics reveals Cdc42 local activation by scaffold-mediated positive feedback and Ras GTPase

Newsemia
by Iker Lamas, Laura Merlini, Aleksandar Vještica, Vincent Vincenzetti, Sophie G. Martin Local activity of the small GTPase Cdc42 is critical for cell polarization. Whereas...
Biology

Loss of MYO5B expression deregulates late endosome size which hinders mitotic spindle orientation

Newsemia
by Changsen Leng, Arend W. Overeem, Fernando Cartón-Garcia, Qinghong Li, Karin Klappe, Jeroen Kuipers, Yingying Cui, Inge S. Zuhorn, Diego Arango, Sven C. D. van...
Biology

Yeast α-arrestin Art2 is the key regulator of ubiquitylation-dependent endocytosis of plasma membrane vitamin B1 transporters

Newsemia
by Jérôme Savocco, Sylvain Nootens, Wilhelmine Afokpa, Mathilde Bausart, Xiaoqian Chen, Jennifer Villers, Henri-François Renard, Martine Prévost, Ruddy Wattiez, Pierre Morsomme Endocytosis of membrane proteins...
Biology

Mechanical stiffness of reconstituted actin patches correlates tightly with endocytosis efficiency

Newsemia
by Jessica Planade, Reda Belbahri, Micaela Boiero Sanders, Audrey Guillotin, Olivia du Roure, Alphée Michelot, Julien Heuvingh Clathrin-mediated endocytosis involves the sequential assembly of more...
Biology

EXP1 is critical for nutrient uptake across the parasitophorous vacuole membrane of malaria parasites

Newsemia
by Paolo Mesén-Ramírez, Bärbel Bergmann, Thuy Tuyen Tran, Matthias Garten, Jan Stäcker, Isabel Naranjo-Prado, Katharina Höhn, Joshua Zimmerberg, Tobias Spielmann Intracellular malaria parasites grow in...
Biology

Loss of Bardet-Biedl syndrome proteins causes synaptic aberrations in principal neurons

Newsemia
by Naila Haq, Christoph Schmidt-Hieber, Fernando J. Sialana, Lorenza Ciani, Janosch P. Heller, Michelle Stewart, Liz Bentley, Sara Wells, Richard J. Rodenburg, Patrick M. Nolan,...
Biology

Reticulon and CLIMP-63 regulate nanodomain organization of peripheral ER tubules

Newsemia
by Guang Gao, Chengjia Zhu, Emma Liu, Ivan R. Nabi The endoplasmic reticulum (ER) is an expansive, membrane-enclosed organelle composed of smooth peripheral tubules and...
Biology

Identification of N-linked glycans as specific mediators of neuronal uptake of acetylated α-Synuclein

Newsemia
by Melissa Birol, Slawomir P. Wojcik, Andrew D. Miranker, Elizabeth Rhoades Cell-to-cell transmission of toxic forms of α-Synuclein (αS) is thought to underlie disease progression...
Biology

Protein interactions and consensus clustering analysis uncover insights into herpesvirus virion structure and function relationships

Newsemia
by Anna Hernández Durán, Todd M. Greco, Benjamin Vollmer, Ileana M. Cristea, Kay Grünewald, Maya Topf Infections with human herpesviruses are ubiquitous and a public...
Biology

CRISPR screening using an expanded toolkit of autophagy reporters identifies TMEM41B as a novel autophagy factor

Newsemia
by Christopher J. Shoemaker, Tina Q. Huang, Nicholas R. Weir, Nicole Polyakov, Sebastian W. Schultz, Vladimir Denic The power of forward genetics in yeast is...
Biology

Multiple functional neurosteroid binding sites on GABA<sub>A</sub> receptors

Newsemia
by Zi-Wei Chen, John R. Bracamontes, Melissa M. Budelier, Allison L. Germann, Daniel J. Shin, Krishnan Kathiresan, Ming-Xing Qian, Brad Manion, Wayland W. L. Cheng,...
Biology

Direct visualization of single-molecule membrane protein interactions in living cells

Newsemia
by Do-Hyeon Kim, Soyeon Park, Dong-Kyun Kim, Min Gyu Jeong, Jungeun Noh, Yonghoon Kwon, Kai Zhou, Nam Ki Lee, Sung Ho Ryu Interactions between membrane...
Biology

More diversity in epithelial cell polarity: A fruit flies’ gut feeling

Newsemia
by H-Arno J. Müller Multicellular animals face the principle challenge to deal with two distinct compartments: the internal organismal compartment and the external environment. This...
Biology

Intramembrane ionic protein–lipid interaction regulates integrin structure and function

Newsemia
by Jun Guo, Youhua Zhang, Hua Li, Huiying Chu, Qinshu Wang, Shutan Jiang, Yan Li, Hongbin Shen, Guohui Li, Jianfeng Chen, Chenqi Xu Protein transmembrane...
Biology

EBP1: A crucial growth regulator downstream of receptor kinases across kingdoms

Newsemia
by Martin Stegmann Controlling organ growth and development is crucial for all multicellular organisms and is controlled by plasma membrane localized receptor kinases (RKs) across...

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