Tag : Mechanistic

Pharma / Biotech

Assessment of romosozumab efficacy in the treatment of postmenopausal osteoporosis: results from a mechanistic PK-PD mechanostat model of bone remodeling.

Newsemia
Related Articles Assessment of romosozumab efficacy in the treatment of postmenopausal osteoporosis: results from a mechanistic PK-PD mechanostat model of bone remodeling. Bone. 2020 Jan...
Pharma / Biotech

Quantitative Proteomics and Mechanistic Modeling of Transporter-mediated Disposition in Non-Alcoholic Fatty Liver Disease.

Newsemia
Related Articles Quantitative Proteomics and Mechanistic Modeling of Transporter-mediated Disposition in Non-Alcoholic Fatty Liver Disease. Clin Pharmacol Ther. 2019 Oct 20;: Authors: Vildhede A, Kimoto...
Pharma / Biotech

Mechanistic profiling of the release kinetics of siRNA from lipidoid-polymer hybrid nanoparticles in vitro and in vivo after pulmonary administration.

Newsemia
Related Articles Mechanistic profiling of the release kinetics of siRNA from lipidoid-polymer hybrid nanoparticles in vitro and in vivo after pulmonary administration. J Control Release....
Pharma / Biotech

Danazol Oral Absorption Modelling in the Fasted Dog: An Example of Mechanistic Understanding of Formulation Effects on Drug Pharmacokinetics.

Newsemia
Related Articles Danazol Oral Absorption Modelling in the Fasted Dog: An Example of Mechanistic Understanding of Formulation Effects on Drug Pharmacokinetics. Eur J Pharm Biopharm....
Pharma / Biotech

Mechanistic investigations of the liver toxicity of the free fatty acid receptor 1 agonist fasiglifam (TAK875) and its primary metabolites.

Newsemia
Related Articles Mechanistic investigations of the liver toxicity of the free fatty acid receptor 1 agonist fasiglifam (TAK875) and its primary metabolites. J Biochem Mol...
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Mechanistic insights from targeted molecular profiling of repolarization alternans in the intact human heart

Newsemia
Orini, M; Yanni, J; Taggart, P; Hanson, B; Hayward, M; Smith, A; Zhang, H; … Lambiase, PD; + view all Orini, M; Yanni, J; Taggart,...
Neurology

A connectome-based mechanistic model of focal cortical dysplasia.

Newsemia
Related Articles A connectome-based mechanistic model of focal cortical dysplasia. Brain. 2019 Feb 05;: Authors: Hong SJ, Lee HM, Gill R, Crane J, Sziklas V,...
AI/ML

Mechanistic Reactivity Descriptors for the Prediction of Ames Mutagenicity of Primary Aromatic Amines.

Newsemia
Related Articles Mechanistic Reactivity Descriptors for the Prediction of Ames Mutagenicity of Primary Aromatic Amines. J Chem Inf Model. 2019 Jan 29;: Authors: Kuhnke L,...
Cardiology

Mechanistic Pathways of ATP Sensitive Potassium Channels Referring to Cardio-Protective Effects and Cellular Functions.

Newsemia
Related Articles Mechanistic Pathways of ATP Sensitive Potassium Channels Referring to Cardio-Protective Effects and Cellular Functions. Drug Res (Stuttg). 2019 Jan 04;: Authors: Vishwakarma VK,...

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