Tag: Mammalian genomics

Biology

Discovery of genes required for body axis and limb formation by global identification of retinoic acid–regulated epigenetic marks

Newsemia
by Marie Berenguer, Karolin F. Meyer, Jun Yin, Gregg Duester Identification of target genes that mediate required functions downstream of transcription factors is hampered by...
Biology

Precise genomic mapping of 5-hydroxymethylcytosine via covalent tether-directed sequencing

Newsemia
by Povilas Gibas, Milda Narmontė, Zdislav Staševskij, Juozas Gordevičius, Saulius Klimašauskas, Edita Kriukienė 5-hydroxymethylcytosine (5hmC) is the most prevalent intermediate on the oxidative DNA demethylation...
Biology

Single-cell transcriptomics of the naked mole-rat reveals unexpected features of mammalian immunity

Newsemia
by Hugo G. Hilton, Nimrod D. Rubinstein, Peter Janki, Andrea T. Ireland, Nicholas Bernstein, Nicole L. Fong, Kevin M. Wright, Megan Smith, David Finkle, Baby...
Biology

KHDC3L mutation causes recurrent pregnancy loss by inducing genomic instability of human early embryonic cells

Newsemia
by Weidao Zhang, Zhongliang Chen, Dengfeng Zhang, Bo Zhao, Lu Liu, Zhengyuan Xie, Yonggang Yao, Ping Zheng Recurrent pregnancy loss (RPL) is an important complication...
Biology

Resurrection of the ancestral RH5 invasion ligand provides a molecular explanation for the origin of <i>P. falciparum</i> malaria in humans

Newsemia
by Francis Galaway, Ryan Yu, Anastasia Constantinou, Franck Prugnolle, Gavin J. Wright Many important infectious diseases are the result of zoonoses, in which pathogens that...
Biology

Widespread selection and gene flow shape the genomic landscape during a radiation of monkeyflowers

Newsemia
by Sean Stankowski, Madeline A. Chase, Allison M. Fuiten, Murillo F. Rodrigues, Peter L. Ralph, Matthew A. Streisfeld Speciation genomic studies aim to interpret patterns...
Biology

Mysteries in embryonic development: How can errors arise so frequently at the beginning of mammalian life?

Newsemia
by Isabell Schneider, Jan Ellenberg Chromosome segregation errors occur frequently during female meiosis but also in the first mitoses of mammalian preimplantation development. Such errors...
Biology

Time-dependent Pax3-mediated chromatin remodeling and cooperation with Six4 and Tead2 specify the skeletal myogenic lineage in developing mesoderm

Newsemia
by Alessandro Magli, June Baik, Lauren J. Mills, Il-Youp Kwak, Bridget S. Dillon, Ricardo Mondragon Gonzalez, David A. Stafford, Scott A. Swanson, Ron Stewart, James...
Biology

Heterochromatin delays CRISPR-Cas9 mutagenesis but does not influence the outcome of mutagenic DNA repair

Newsemia
by Eirini M. Kallimasioti-Pazi, Keerthi Thelakkad Chathoth, Gillian C. Taylor, Alison Meynert, Tracy Ballinger, Martijn J. E. Kelder, Sébastien Lalevée, Ildem Sanli, Robert Feil, Andrew...
Biology

Long-distance communication: Looping of human papillomavirus genomes regulates expression of viral oncogenes

Newsemia
by Adityarup Chakravorty, Bill Sugden High-risk human papillomaviruses (HPVs) are a major cause of cancers. HPVs infect epithelial cells, and viral oncogenes disrupt several cellular...
Biology

Similarities and differences in the regulation of <i>HoxD</i> genes during chick and mouse limb development

Newsemia
by Nayuta Yakushiji-Kaminatsui, Lucille Lopez-Delisle, Christopher Chase Bolt, Guillaume Andrey, Leonardo Beccari, Denis Duboule In all tetrapods examined thus far, the development and patterning of...
Biology

Noncoding RNA Ginir functions as an oncogene by associating with centrosomal proteins

Newsemia
by Suchismita Panda, Meenakshi Setia, Navjot Kaur, Varsha Shepal, Vivek Arora, Divya Kumari Singh, Abir Mondal, Abhishek Teli, Madhura Tathode, Rajendra Gajula, L. C. Padhy,...
Biology

Anthropoid primate–specific retroviral element THE1B controls expression of <i>CRH</i> in placenta and alters gestation length

Newsemia
by Caitlin E. Dunn-Fletcher, Lisa M. Muglia, Mihaela Pavlicev, Gernot Wolf, Ming-An Sun, Yueh-Chiang Hu, Elizabeth Huffman, Shivani Tumukuntala, Katri Thiele, Amrita Mukherjee, Sandra Zoubovsky,...
Biology

<i>Plasmodium vivax</i>-like genome sequences shed new insights into <i>Plasmodium vivax</i> biology and evolution

Newsemia
by Aude Gilabert, Thomas D. Otto, Gavin G. Rutledge, Blaise Franzon, Benjamin Ollomo, Céline Arnathau, Patrick Durand, Nancy D. Moukodoum, Alain-Prince Okouga, Barthélémy Ngoubangoye, Boris...
Biology

<i>Plasmodium vivax</i>-like genome sequences shed new insights into <i>Plasmodium vivax</i> biology and evolution

Newsemia
by Aude Gilabert, Thomas D. Otto, Gavin G. Rutledge, Blaise Franzon, Benjamin Ollomo, Céline Arnathau, Patrick Durand, Nancy D. Moukodoum, Alain-Prince Okouga, Barthélémy Ngoubangoye, Boris...

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