Tag: ligand

Pharma / Biotech

The Optimisation of a Novel, Weak Bromo and Extra Terminal Domain (BET) Bromodomain Fragment Ligand to a Potent and Selective Second Bromodomain (BD2) Inhibitor.

Newsemia
Related Articles The Optimisation of a Novel, Weak Bromo and Extra Terminal Domain (BET) Bromodomain Fragment Ligand to a Potent and Selective Second Bromodomain (BD2)...
Neurology

Researchers show how upregulation of a single gene by SARs-CoV-2 can trigger cytokine storm

Newsemia
The SARS-CoV-19 virus initially has a limited capability to invade, attacking only one intracellular genetic target, the aryl hydrocarbon receptors (AhRs). Source link...
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Direct structural link between SARS-CoV-2 and essential fatty acid

Newsemia
Now, a new study published on the preprint server bioRxiv in June 2020 reports the discovery of a novel free fatty acid (FFA) binding pocket...
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New family of molecules to join altered receptors in Alzheimer's, Parkinson's and Huntington's

Newsemia
An article published in the Journal of Medicinal Chemistry shows a new family of molecules with high affinity to join imidazoline receptors, which are altered...
Pharma / Biotech

Tuning Ligand Density to Optimize Pharmacokinetics of Targeted Nanoparticles for Dual Protection against Tumor-Induced Bone Destruction.

Newsemia
Related Articles Tuning Ligand Density to Optimize Pharmacokinetics of Targeted Nanoparticles for Dual Protection against Tumor-Induced Bone Destruction. ACS Nano. 2020 Jan 02;: Authors: Vanderburgh...
Pharma / Biotech

The effect of ligand amount, affinity and internalization on PSMA-targeted imaging and therapy: A simulation study using a PBPK model.

Newsemia
Related Articles The effect of ligand amount, affinity and internalization on PSMA-targeted imaging and therapy: A simulation study using a PBPK model. Sci Rep. 2019...
Dentistry

Serum Flt3 ligand is a biomarker of progenitor cell mass and prognosis in acute myeloid leukemia.

Newsemia
Serum Flt3 ligand is a biomarker of progenitor cell mass and prognosis in acute myeloid leukemia. Blood Adv. 2019 Oct 22;3(20):3052-3061 Authors: Milne P, Wilhelm-Benartzi...
Biology

Resurrection of the ancestral RH5 invasion ligand provides a molecular explanation for the origin of <i>P. falciparum</i> malaria in humans

Newsemia
by Francis Galaway, Ryan Yu, Anastasia Constantinou, Franck Prugnolle, Gavin J. Wright Many important infectious diseases are the result of zoonoses, in which pathogens that...
Pharma / Biotech

Exosome-like nanoplatform modified with targeting ligand improves anti-cancer and anti-inflammation effects of imperialine.

Newsemia
Related Articles Exosome-like nanoplatform modified with targeting ligand improves anti-cancer and anti-inflammation effects of imperialine. J Control Release. 2019 Sep 01;: Authors: Lin Q, Qu...

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