Tag: LCMSMS

Pharma / Biotech

Development and validation of a LC-MS/MS method for simultaneous determination of TQ-A3326 and its major metabolites in human plasma, urine and feces: application to pharmacokinetic assay.

Newsemia
Related Articles Development and validation of a LC-MS/MS method for simultaneous determination of TQ-A3326 and its major metabolites in human plasma, urine and feces: application...
Pharma / Biotech

Utilising magnetically isolated lysosomes for direct quantification of intralysosomal drug concentrations by LC-MS/MS analysis: An investigatory study with imipramine.

Newsemia
Related Articles Utilising magnetically isolated lysosomes for direct quantification of intralysosomal drug concentrations by LC-MS/MS analysis: An investigatory study with imipramine. J Pharm Sci. 2020...
Pharma / Biotech

LC-MS/MS determination of buparlisib, a phosphoinositide 3 kinase inhibitor in rat plasma: application to a pharmacokinetic study.

Newsemia
Related Articles LC-MS/MS determination of buparlisib, a phosphoinositide 3 kinase inhibitor in rat plasma: application to a pharmacokinetic study. Biomed Chromatogr. 2020 Feb 28;:e4816 Authors:...
Pharma / Biotech

Bioactive indanes: Development and validation of an LC-MS/MS bioanalytical method for the determination of PH46A, a new potential anti-inflammatory agent, in dog and rat plasma and its application to a pharmacokinetic study in dog.

Newsemia
Related Articles Bioactive indanes: Development and validation of an LC-MS/MS bioanalytical method for the determination of PH46A, a new potential anti-inflammatory agent, in dog and...
Pharma / Biotech

Optimization of chromatography to overcome matrix effect for reliable estimation of four small molecular drugs from biological fluids using LC-MS/MS.

Newsemia
Related Articles Optimization of chromatography to overcome matrix effect for reliable estimation of four small molecular drugs from biological fluids using LC-MS/MS. Biomed Chromatogr. 2019...
Pharma / Biotech

Development and application of a rapid and sensitive LC-MS/MS method for simultaneous quantification of six diterpene lactones in rats after oral administration of Rhizoma Dioscoreae Bulbiferae extract.

Newsemia
Related Articles Development and application of a rapid and sensitive LC-MS/MS method for simultaneous quantification of six diterpene lactones in rats after oral administration of...
Pharma / Biotech

Pharmacokinetics, bioavailability and urinary excretion of scopolin and its metabolite scopoletin in Sprague-Dawley rats by LC-MS/MS.

Newsemia
Related Articles Pharmacokinetics, bioavailability and urinary excretion of scopolin and its metabolite scopoletin in Sprague-Dawley rats by LC-MS/MS. Biomed Chromatogr. 2019 Aug 14;:e4678 Authors: Li...
Pharma / Biotech

Simultaneous determination of five active alkaloids from Compound Kushen Injection in rat plasma by LC-MS/MS and its application to a comparative pharmacokinetic study in normal and NSCLC nude rats.

Newsemia
Related Articles Simultaneous determination of five active alkaloids from Compound Kushen Injection in rat plasma by LC-MS/MS and its application to a comparative pharmacokinetic study...
Pharma / Biotech

Challenges in simultaneous extraction and chromatographic separation of metformin and three SGLT-2 inhibitors in human plasma using LC-MS/MS.

Newsemia
Related Articles Challenges in simultaneous extraction and chromatographic separation of metformin and three SGLT-2 inhibitors in human plasma using LC-MS/MS. J Pharm Biomed Anal. 2019...
Pharma / Biotech

Pharmacokinetics, bioavailability, and tissue distribution studies of rhodojaponin III in mice using QTRAP LC-MS/MS.

Newsemia
Pharmacokinetics, bioavailability, and tissue distribution studies of rhodojaponin III in mice using QTRAP LC-MS/MS. Biomed Chromatogr. 2019 Jul 13;:e4649 Authors: Zhang JQ, Zhao CC, Yang...
Pharma / Biotech

Simultaneous determination of paclitaxel and lansoprazole in rat plasma by LC-MS/MS method and its application to a preclinical pharmacokinetic study of investigational PTX-LAN-PLGA nanoformulation.

Newsemia
Related Articles Simultaneous determination of paclitaxel and lansoprazole in rat plasma by LC-MS/MS method and its application to a preclinical pharmacokinetic study of investigational PTX-LAN-PLGA...
Pharma / Biotech

Development and validation of a sensitive LC-MS/MS method for determination of gefitinib and its major metabolites in human plasma and its application in non-small cell lung cancer patients.

Newsemia
Related Articles Development and validation of a sensitive LC-MS/MS method for determination of gefitinib and its major metabolites in human plasma and its application in...
Pharma / Biotech

A reliable LC-MS/MS method for the quantification of five bioactive saponins of crude and processed Bupleurum scorzonerifolium in rat plasma and its application to a pharmacokinetic study.

Newsemia
A reliable LC-MS/MS method for the quantification of five bioactive saponins of crude and processed Bupleurum scorzonerifolium in rat plasma and its application to a...
Pharma / Biotech

Development and validation of a sensitive LC-MS/MS method for the determination of 6-hydroxykynurenic acid in rat plasma and its application to pharmacokinetics study.

Newsemia
Related Articles Development and validation of a sensitive LC-MS/MS method for the determination of 6-hydroxykynurenic acid in rat plasma and its application to pharmacokinetics study....
Pharma / Biotech

Simultaneous determination of three saponins in human plasma after oral administration of compound danshen dripping pills by LC-MS/MS and its application in a pharmacokinetic study.

Newsemia
Related Articles Simultaneous determination of three saponins in human plasma after oral administration of compound danshen dripping pills by LC-MS/MS and its application in a...
Pharma / Biotech

Development and validation of a specific and sensitive LC-MS/MS method for determination of eslicarbazepine in human plasma and its clinical pharmacokinetic study.

Newsemia
Related Articles Development and validation of a specific and sensitive LC-MS/MS method for determination of eslicarbazepine in human plasma and its clinical pharmacokinetic study. J...
Pharma / Biotech

Therapeutic drug monitoring of teicoplanin using an LC-MS/MS method: Analysis of 421 measurements in a naturalistic clinical setting.

Newsemia
Related Articles Therapeutic drug monitoring of teicoplanin using an LC-MS/MS method: Analysis of 421 measurements in a naturalistic clinical setting. J Pharm Biomed Anal. 2019...

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