Tag : Kinases

Gastroenterology

Integrated analysis of multiple receptor tyrosine kinases identifies Axl as a therapeutic target and mediator of resistance to sorafenib in hepatocellular carcinoma

Newsemia
Integrated analysis of multiple receptor tyrosine kinases identifies Axl as a therapeutic target and mediator of resistance to sorafenib in hepatocellular carcinoma Source link...
Biology

Irreversible Activation of Rho-activated Kinases Resulted from Evolution of Proteolytic Sites within Disordered Regions in Coiled-coil Domain

Newsemia
Abstract Activation of Rho-associated protein kinase 1 (ROCK1) and myotonic dystrophy kinase-related CDC42-binding kinase alpha (MRCK╬▒) by caspases during apoptosis in vertebrates represents a prototypical...
Pharma / Biotech

Chemically reprogramming the phospho-transfer reaction to crosslink protein kinases to their substrates.

Newsemia
Related Articles Chemically reprogramming the phospho-transfer reaction to crosslink protein kinases to their substrates. Protein Sci. 2019 Jan 13;: Authors: Wong AW, Urisman A, Burlingame...
Biology

Adaptation to Endoplasmic Reticulum Stress Requires Transphosphorylation within the Activation Loop of Protein Kinases Kin1 and Kin2, Orthologs of Human Microtubule Affinity-Regulating Kinase [Research Article]

Newsemia
Perturbations in endoplasmic reticulum (ER) homeostasis, a condition termed ER stress, activate the unfolded protein response (UPR), an intracellular network of signaling pathways. Recently, we...
Biology

EBP1: A crucial growth regulator downstream of receptor kinases across kingdoms

Newsemia
by Martin Stegmann Controlling organ growth and development is crucial for all multicellular organisms and is controlled by plasma membrane localized receptor kinases (RKs) across...
Pharma / Biotech

Involvement of vascular endothelial growth factor (VEGF) and mitogen-activated protein kinases (MAPK) in the mechanism of neuroleptic drugs.

Newsemia
Related Articles Involvement of vascular endothelial growth factor (VEGF) and mitogen-activated protein kinases (MAPK) in the mechanism of neuroleptic drugs. Pharmacol Rep. 2018 Aug 22;70(5):1032-1039...
Biology

Receptor-Like Cytoplasmic Kinases Directly Link Diverse Pattern Recognition Receptors to the Activation of Mitogen-Activated Protein Kinase Cascades in Arabidopsis

Newsemia
Plants deploy numerous cell surface-localized pattern-recognition receptors (PRRs) to perceive host- and microbe-derived molecular patterns that are specifically released during infection and activate defense responses....
Latest News

Inositol Polyphosphate Kinases, Fungal Virulence and Drug Discovery

Newsemia
Li, C; Lev, S; Saiardi, A; Desmarini, D; Sorrell, TC; Djordjevic, JT; (2016) Inositol Polyphosphate Kinases, Fungal Virulence and Drug Discovery. Journal of Fungi ,...

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