Tag : Kinase

Latest News

FDA approves LORBRENA for treatment of patients with ALK-positive metastatic NSCLC

Newsemia
Pfizer Inc. today announced that the U.S. Food and Drug Administration has approved LORBRENA, a third-generation anaplastic lymphoma kinase tyrosine kinase inhibitor for patients with...
Pharma / Biotech

The Connection Between the Cardiac Glycoside-Induced Senescent Cell Morphology and Rho/Rho Kinase Pathway.

Newsemia
Related Articles The Connection Between the Cardiac Glycoside-Induced Senescent Cell Morphology and Rho/Rho Kinase Pathway. Cytoskeleton (Hoboken). 2018 Oct 28;: Authors: Şimay YD, Özdemir A,...
Neurology

AMP-Activated Protein Kinase Is Essential for the Maintenance of Energy Levels during Synaptic Activation.

Newsemia
Related Articles AMP-Activated Protein Kinase Is Essential for the Maintenance of Energy Levels during Synaptic Activation. iScience. 2018 Oct 12;9:1-13 Authors: Marinangeli C, Didier S,...
Gastroenterology

Study: Targeting specific genomic mutation in breast cancer improves survival

Newsemia
Targeting a common mutation in patients with hormone receptor positive (HR+) HER2 negative (HER2-) advanced breast cancer with the alpha-specific phosphatidylinositol-3-kinase (PI3K) inhibitor alpelisib significantly...
Gastroenterology

Takeda announces positive Phase 3 ALTA-1L data in first-line therapy for advanced ALK+ NSCLC

Newsemia
Takeda Pharmaceutical Company Limited today announced that intracranial efficacy data from the Phase 3 ALTA-1L (ALK in Lung Cancer Trial of BrigAtinib in 1st Line)...
Gastroenterology

CHMP adopts positive opinion of Takeda’s ALUNBRIG for treatment of ALK+ non-small cell lung cancer

Newsemia
Takeda Pharmaceutical Company Limited today announced that the European Medicines Agency’s Committee for Medicinal Products for Human Use has adopted a positive opinion, recommending the...
Biology

Protein kinase A negatively regulates Ca<sup>2+</sup> signalling in <i>Toxoplasma gondii</i>

Newsemia
by Alessandro D. Uboldi, Mary-Louise Wilde, Emi A. McRae, Rebecca J. Stewart, Laura F. Dagley, Luning Yang, Nicholas J. Katris, Sanduni V. Hapuarachchi, Michael J....
Biology

Ribosomal RACK1:Protein Kinase C {beta}II Modulates Intramolecular Interactions between Unstructured Regions of Eukaryotic Initiation Factor 4G (eIF4G) That Control eIF4E and eIF3 Binding [Research Article]

Newsemia
The receptor for activated C kinase (RACK1), a conserved constituent of eukaryotic ribosomes, mediates phosphorylation of eukaryotic initiation factor 4G1(S1093) [eIF4G1(S1093)] and eIF3a(S1364) by protein...
Biology

Ribosomal RACK1:Protein Kinase C {beta}II Phosphorylates Eukaryotic Initiation Factor 4G1 at S1093 To Modulate Cap-Dependent and -Independent Translation Initiation [Research Article]

Newsemia
Eukaryotic ribosomes contain the high-affinity protein kinase C βII (PKCβII) scaffold, receptor for activated C kinase (RACK1), but its role in protein synthesis control remains...
Latest News

New research on molecular mechanistic understanding of drug delivery and drug delivery systems

Newsemia
Today, Insilico Medicine, Inc., a Rockville-based next-generation artificial intelligence company specializing in the application of deep learning for target identification, drug discovery and aging research...
AI/ML

Machine Learning Predicts the Yeast Metabolome from the Quantitative Proteome of Kinase Knockouts.

Newsemia
Related Articles Machine Learning Predicts the Yeast Metabolome from the Quantitative Proteome of Kinase Knockouts. Cell Syst. 2018 Aug 20;: Authors: Zelezniak A, Vowinckel J,...

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