Tag : Kinase

Biology

Protein kinase A negatively regulates Ca<sup>2+</sup> signalling in <i>Toxoplasma gondii</i>

Newsemia
by Alessandro D. Uboldi, Mary-Louise Wilde, Emi A. McRae, Rebecca J. Stewart, Laura F. Dagley, Luning Yang, Nicholas J. Katris, Sanduni V. Hapuarachchi, Michael J....
Biology

Ribosomal RACK1:Protein Kinase C {beta}II Modulates Intramolecular Interactions between Unstructured Regions of Eukaryotic Initiation Factor 4G (eIF4G) That Control eIF4E and eIF3 Binding [Research Article]

Newsemia
The receptor for activated C kinase (RACK1), a conserved constituent of eukaryotic ribosomes, mediates phosphorylation of eukaryotic initiation factor 4G1(S1093) [eIF4G1(S1093)] and eIF3a(S1364) by protein...
Biology

Ribosomal RACK1:Protein Kinase C {beta}II Phosphorylates Eukaryotic Initiation Factor 4G1 at S1093 To Modulate Cap-Dependent and -Independent Translation Initiation [Research Article]

Newsemia
Eukaryotic ribosomes contain the high-affinity protein kinase C βII (PKCβII) scaffold, receptor for activated C kinase (RACK1), but its role in protein synthesis control remains...
Latest News

New research on molecular mechanistic understanding of drug delivery and drug delivery systems

Newsemia
Today, Insilico Medicine, Inc., a Rockville-based next-generation artificial intelligence company specializing in the application of deep learning for target identification, drug discovery and aging research...
AI/ML

Machine Learning Predicts the Yeast Metabolome from the Quantitative Proteome of Kinase Knockouts.

Newsemia
Related Articles Machine Learning Predicts the Yeast Metabolome from the Quantitative Proteome of Kinase Knockouts. Cell Syst. 2018 Aug 20;: Authors: Zelezniak A, Vowinckel J,...
Cardiology

Amelioration of mitochondrial dysfunction in heart failure through S-sulfhydration of Ca2+/calmodulin-dependent protein kinase II.

Newsemia
Related Articles Amelioration of mitochondrial dysfunction in heart failure through S-sulfhydration of Ca2+/calmodulin-dependent protein kinase II. Redox Biol. 2018 Aug 22;19:250-262 Authors: Wu D, Hu...
Gastroenterology

NCCN updates Clinical Practice Guidelines to include new recommendations for CABOMETYX tablets

Newsemia
Exelixis, Inc. today announced that the National Comprehensive Cancer Network updated its Clinical Practice Guidelines to include new recommendations for CABOMETYX tablets. Source link...
Pharma / Biotech

Clinical Pharmacokinetic and Pharmacodynamic Overview of Nilotinib, a Selective Tyrosine Kinase Inhibitor.

Newsemia
Related Articles Clinical Pharmacokinetic and Pharmacodynamic Overview of Nilotinib, a Selective Tyrosine Kinase Inhibitor. J Clin Pharmacol. 2018 Sep 04;: Authors: Tian X, Zhang H,...
Biology

Effects of GS-9876, a novel spleen tyrosine kinase inhibitor, on platelet function and systemic hemostasis.

Newsemia
Related Articles Effects of GS-9876, a novel spleen tyrosine kinase inhibitor, on platelet function and systemic hemostasis. Thromb Res. 2018 Aug 23;170:109-118 Authors: Clarke AS,...
Neurology

Eisai: EC approves marketing of LENVIMA as first-line treatment for hepatocellular carcinoma

Newsemia
Eisai Co., Ltd. and Merck & Co., Inc., Kenilworth N.J., U.S.A., known as MSD outside of the United States and Canada, announced today that the...
Biology

Receptor-Like Cytoplasmic Kinases Directly Link Diverse Pattern Recognition Receptors to the Activation of Mitogen-Activated Protein Kinase Cascades in Arabidopsis

Newsemia
Plants deploy numerous cell surface-localized pattern-recognition receptors (PRRs) to perceive host- and microbe-derived molecular patterns that are specifically released during infection and activate defense responses....
Cardiology

AMP-activated protein kinase sparks the fire of cardioprotection against myocardial ischemia and cardiac ageing.

Newsemia
Related Articles AMP-activated protein kinase sparks the fire of cardioprotection against myocardial ischemia and cardiac ageing. Ageing Res Rev. 2018 Aug 12;: Authors: Gu C,...

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