Kinase

Neuropathy with vascular endothelial growth factor receptor tyrosine kinase inhibitors: A meta-analysis

Objective To explore the association of peripheral neuropathy with vascular endothelial growth factor receptor tyrosine kinase inhibitors (VEGFR-TKIs) use in patients with cancer. Methods Published data search up to November...

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Histomorphology of pancreatic cancer in patients with inherited ATM serine/threonine kinase pathogenic variants

Histomorphology of pancreatic cancer in patients with inherited ATM serine/threonine kinase pathogenic variants Source link

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Scientists uncover new pathway to make cancers self-destruct

For years, researchers have been trying to target a gene called MYC that is known to drive tumor growth in multiple cancer types when it is mutated or over-expressed, but...

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Unexpected mechanism allows a protein kinase to decode calcium signaling in the brain

A new study from researchers at Max Planck Florida Institute for Neuroscience (MPFI) has shed light on the unexpected mechanism that allows calcium/calmodulin-dependent protein kinase, or CaMKII, to decode and...

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UAB scientists identify new target for drug intervention in Alzheimer's disease

Scientists at the University of Alabama at Birmingham have identified an enzyme in the brain that may be an intriguing target for interventions against Alzheimer's disease and other dementias. Source...

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Evolution of protein kinase substrate recognition at the active site

by David Bradley, Pedro Beltrao Protein kinases catalyse the phosphorylation of target proteins, controlling most cellular processes. The specificity of serine/threonine kinases is partly determined by interactions with a few...

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Researchers identify enzymes that protect people from diabetic kidney disease

A new study from Joslin Diabetes Center has proven that certain biological protective factors play a large role in preventing diabetic kidney disease in certain people. The study was published...

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Rice qGL3/OsPPKL1 Functions with the GSK3/SHAGGY-Like Kinase OsGSK3 to Modulate Brassinosteroid Signaling

Brassinosteroids (BRs) are steroid hormones that play essential roles in plant growth and development. We previously cloned qGL3, a major quantitative trait locus regulating grain length in rice (Oryza sativa)....

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GP78 Cooperates with Dual-Specificity Phosphatase 1 To Stimulate Epidermal Growth Factor Receptor-Mediated Extracellular Signal-Regulated Kinase Signaling [Research Article]

GP78 is an autocrine motility factor (AMF) receptor (AMFR) with E3 ubiquitin ligase activity that plays a significant role in tumor cell proliferation, motility, and metastasis. Aberrant extracellular signal-regulated kinase...

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A First-Time-in-Human Study of GSK2636771, a Phosphoinositide 3 Kinase Beta-Selective Inhibitor, in Patients with Advanced Solid Tumors

[ad_1] Mateo, J; Ganji, G; Lemech, C; Burris, HA; Han, S-W; Swales, K; Decordova, S; ... Arkenau, H-T; + view all Mateo, J; Ganji, G; Lemech, C; Burris, HA; Han,...

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Study finds promising new treatment for infants with Noonan Syndrome

[ad_1] Noonan Syndrome is a rare genetic syndrome typically evident at birth and often linked to early-onset severe heart disease. Source link [ad_2]

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Natural polymorphism in protein kinase G modulates functional senescence in Drosophila melanogaster [RESEARCH ARTICLE]

Stephanie P. Kelly and Ken Dawson-Scully The common fruit fly, Drosophila melanogaster, is a well-characterized model for neurological disorders and is widely used to investigate the biology of aging, stress...

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FDA Approves First FGFR Kinase Inhibitor for Advanced Bladder Ca

The FDA granted accelerated approval to erdafitinib (Balversa, Janssen) for the treatment of adults with locally advanced or metastatic urothelial cancer with susceptible fibroblast growth factor receptor alterations that has...

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The Molecular Chaperone Heat Shock Protein 70 Controls Liver Cancer Initiation and Progression by Regulating Adaptive DNA Damage and Mitogen-Activated Protein Kinase/Extracellular Signal-Regulated Kinase Signaling Pathways [Research Article]

Delineating the mechanisms that drive hepatic injury and hepatocellular carcinoma (HCC) progression is critical for development of novel treatments for recurrent and advanced HCC but also for the development of...

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MST1R kinase accelerates pancreatic cancer progression via effects on both epithelial cells and macrophages

[ad_1] MST1R kinase accelerates pancreatic cancer progression via effects on both epithelial cells and macrophages Source link [ad_1]

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Mutation in Huntington’s disease may alter interactions of Huntingtin protein with Rac1

Since 1993, when the gene that causes Huntington's disease was identified, there has been intense focus on understanding how this genetic mutation causes the disease's severe progressive neural deterioration. Source...

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Nucleoside analogue activators of cyclic AMP-independent protein kinase A of Trypanosoma

The post Nucleoside analogue activators of cyclic AMP-independent protein kinase A of Trypanosoma appeared first on Biochemistry Blog: Biochemistry Help. Source link

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Comprehensive profiling of the STE20 kinase family defines features essential for selective substrate targeting and signaling output

by Chad J. Miller, Hua Jane Lou, Craig Simpson, Bert van de Kooij, Byung Hak Ha, Oriana S. Fisher, Natasha L. Pirman, Titus J. Boggon, Jesse Rinehart, Michael B. Yaffe,...

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Natural polymorphism in protein kinase G modulates functional senescence in D. melanogaster [RESEARCH ARTICLE]

Stephanie P. Kelly and Ken Dawson-ScullyThe common fruit fly, Drosophila melanogaster, is a well-characterized model for neurological disorders and is widely used to investigate the biology of aging, stress tolerance,...

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Increased Expression of MicroRNA 551a by c-Fos Reduces Focal Adhesion Kinase Levels and Blocks Tumorigenesis [Research Article]

Breast cancer is a recurrent type of cancer among women worldwide. Despite remarkable progress in the prevention, detection, and treatment of breast cancer, it still remains a major chronic problem...

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