Tag : Kinase

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Plasma monitoring of EGFR mutations in NSCLC may help predict resistance to tyrosine kinase inhibitors

Newsemia
Oncotarget Volume 11, Issue 11 reported that at clinical progression, 64 EGFR T790M plasma positive patients were subjected to second line-treatment with osimertinib and strictly...
Pharma / Biotech

Safety, Pharmacokinetics and Pharmacodynamics of Branebrutinib (BMS-986195), a Covalent, Irreversible Inhibitor of Bruton's Tyrosine Kinase: Randomised Phase I, Placebo-Controlled Trial in Healthy Participants.

Newsemia
Safety, Pharmacokinetics and Pharmacodynamics of Branebrutinib (BMS-986195), a Covalent, Irreversible Inhibitor of Bruton’s Tyrosine Kinase: Randomised Phase I, Placebo-Controlled Trial in Healthy Participants. Br J...
Biology

A Redox-Sensitive Thiol in Wis1 Modulates the Fission Yeast Mitogen-Activated Protein Kinase Response to H2O2 and Is the Target of a Small Molecule [Research Article]

Newsemia
Oxidation of a highly conserved cysteine (Cys) residue located in the kinase activation loop of mitogen-activated protein kinase kinases (MAPKK) inactivates mammalian MKK6. This residue...
Biology

The receptor tyrosine kinase Ror is required for dendrite regeneration in <i>Drosophila</i> neurons

Newsemia
by Derek M. R. Nye, Richard M. Albertson, Alexis T. Weiner, J. Ian Hertzler, Matthew Shorey, Deborah C. I. Goberdhan, Clive Wilson, Kevin A. Janes,...
Latest News

Drugging the catalytically inactive state of RET kinase in RET-rearranged tumors

Newsemia
Plenker, D; Riedel, M; Braegelmann, J; Dammert, MA; Chauhan, R; Knowles, PP; Lorenz, C; … Sos, ML; + view all Plenker, D; Riedel, M; Braegelmann,...
Gastroenterology

Imatinib in combination with phosphoinositol kinase inhibitor buparlisib in patients with gastrointestinal stromal tumour who failed prior therapy with imatinib and sunitinib: a Phase 1b, multicentre study

Newsemia
Imatinib in combination with phosphoinositol kinase inhibitor buparlisib in patients with gastrointestinal stromal tumour who failed prior therapy with imatinib and sunitinib: a Phase 1b,...
Pharma / Biotech

LC-MS/MS determination of buparlisib, a phosphoinositide 3 kinase inhibitor in rat plasma: application to a pharmacokinetic study.

Newsemia
Related Articles LC-MS/MS determination of buparlisib, a phosphoinositide 3 kinase inhibitor in rat plasma: application to a pharmacokinetic study. Biomed Chromatogr. 2020 Feb 28;:e4816 Authors:...
Latest News

Prolonged exposure to a pair of antioxidant proteins may fuel liver enlargement

Newsemia
All life is challenged by oxidants — reactive molecules or compounds that remove electrons from other molecules — often with adverse effect, commonly referred to...
Biology

Priming Phosphorylation of TANK-Binding Kinase 1 by I{kappa}B Kinase {beta} Is Essential in Toll-Like Receptor 3/4 Signaling [Research Article]

Newsemia
TRIF is an essential adaptor for Toll-like receptor 3/4 (TLR3/4) signaling to activate transcription factor interferon regulatory factor 3 (IRF-3). We examined the molecular mechanism...
Pharma / Biotech

Development of a potent and orally active activator of adenosine monophosphate-activated protein kinase (AMPK), ASP4132, as a clinical candidate for the treatment of human cancer.

Newsemia
Related Articles Development of a potent and orally active activator of adenosine monophosphate-activated protein kinase (AMPK), ASP4132, as a clinical candidate for the treatment of...
Biology

Dynamic Phosphorylation and Dephosphorylation of Cyclase-Associated Protein 1 by Antagonistic Signaling through Cyclin-Dependent Kinase 5 and cAMP Are Critical for the Protein Functions in Actin Filament Disassembly and Cell Adhesion [Research Article]

Newsemia
Cyclase-associated protein 1 (CAP1) is a conserved actin-regulating protein that enhances actin filament dynamics and also regulates adhesion in mammalian cells. We previously found that...
Gastroenterology

Safety of Janus Kinase Inhibitors in Patients with Inflammatory Bowel Diseases or Other Immune-mediated Diseases: a Systematic Review and Meta-Analysis

Newsemia
Inhibitors of Janus kinases (JAKs) are being developed for treatment of inflammatory bowel diseases and other immune-mediated diseases. Tofacitinib is effective in treatment of ulcerative...
Latest News

PAK4 Kinase Activity Plays a Crucial Role in the Podosome Ring of Myeloid Cells

Newsemia
Foxall, E; Staszowska, A; Hirvonen, LM; Georgouli, M; Ciccioli, M; Rimmer, A; Williams, L; … Wells, CM; + view all Foxall, E; Staszowska, A; Hirvonen,...
Pharma / Biotech

Pharmacology of tyrosine kinase inhibitors in chronic myeloid leukemia; a clinician's perspective.

Newsemia
Related Articles Pharmacology of tyrosine kinase inhibitors in chronic myeloid leukemia; a clinician’s perspective. Daru. 2020 Jan 03;: Authors: Pushpam D, Bakhshi S Abstract OBJECTIVE:...

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