Kinase

Rice qGL3/OsPPKL1 Functions with the GSK3/SHAGGY-Like Kinase OsGSK3 to Modulate Brassinosteroid Signaling

Brassinosteroids (BRs) are steroid hormones that play essential roles in plant growth and development. We previously cloned qGL3, a major quantitative trait locus regulating grain length in rice (Oryza sativa)....

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GP78 Cooperates with Dual-Specificity Phosphatase 1 To Stimulate Epidermal Growth Factor Receptor-Mediated Extracellular Signal-Regulated Kinase Signaling [Research Article]

GP78 is an autocrine motility factor (AMF) receptor (AMFR) with E3 ubiquitin ligase activity that plays a significant role in tumor cell proliferation, motility, and metastasis. Aberrant extracellular signal-regulated kinase...

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A First-Time-in-Human Study of GSK2636771, a Phosphoinositide 3 Kinase Beta-Selective Inhibitor, in Patients with Advanced Solid Tumors

[ad_1] Mateo, J; Ganji, G; Lemech, C; Burris, HA; Han, S-W; Swales, K; Decordova, S; ... Arkenau, H-T; + view all Mateo, J; Ganji, G; Lemech, C; Burris, HA; Han,...

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Study finds promising new treatment for infants with Noonan Syndrome

[ad_1] Noonan Syndrome is a rare genetic syndrome typically evident at birth and often linked to early-onset severe heart disease. Source link [ad_2]

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Natural polymorphism in protein kinase G modulates functional senescence in Drosophila melanogaster [RESEARCH ARTICLE]

Stephanie P. Kelly and Ken Dawson-Scully The common fruit fly, Drosophila melanogaster, is a well-characterized model for neurological disorders and is widely used to investigate the biology of aging, stress...

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FDA Approves First FGFR Kinase Inhibitor for Advanced Bladder Ca

The FDA granted accelerated approval to erdafitinib (Balversa, Janssen) for the treatment of adults with locally advanced or metastatic urothelial cancer with susceptible fibroblast growth factor receptor alterations that has...

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The Molecular Chaperone Heat Shock Protein 70 Controls Liver Cancer Initiation and Progression by Regulating Adaptive DNA Damage and Mitogen-Activated Protein Kinase/Extracellular Signal-Regulated Kinase Signaling Pathways [Research Article]

Delineating the mechanisms that drive hepatic injury and hepatocellular carcinoma (HCC) progression is critical for development of novel treatments for recurrent and advanced HCC but also for the development of...

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MST1R kinase accelerates pancreatic cancer progression via effects on both epithelial cells and macrophages

[ad_1] MST1R kinase accelerates pancreatic cancer progression via effects on both epithelial cells and macrophages Source link [ad_1]

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Mutation in Huntington’s disease may alter interactions of Huntingtin protein with Rac1

Since 1993, when the gene that causes Huntington's disease was identified, there has been intense focus on understanding how this genetic mutation causes the disease's severe progressive neural deterioration. Source...

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Nucleoside analogue activators of cyclic AMP-independent protein kinase A of Trypanosoma

The post Nucleoside analogue activators of cyclic AMP-independent protein kinase A of Trypanosoma appeared first on Biochemistry Blog: Biochemistry Help. Source link

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Comprehensive profiling of the STE20 kinase family defines features essential for selective substrate targeting and signaling output

by Chad J. Miller, Hua Jane Lou, Craig Simpson, Bert van de Kooij, Byung Hak Ha, Oriana S. Fisher, Natasha L. Pirman, Titus J. Boggon, Jesse Rinehart, Michael B. Yaffe,...

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Natural polymorphism in protein kinase G modulates functional senescence in D. melanogaster [RESEARCH ARTICLE]

Stephanie P. Kelly and Ken Dawson-ScullyThe common fruit fly, Drosophila melanogaster, is a well-characterized model for neurological disorders and is widely used to investigate the biology of aging, stress tolerance,...

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Increased Expression of MicroRNA 551a by c-Fos Reduces Focal Adhesion Kinase Levels and Blocks Tumorigenesis [Research Article]

Breast cancer is a recurrent type of cancer among women worldwide. Despite remarkable progress in the prevention, detection, and treatment of breast cancer, it still remains a major chronic problem...

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Correction for A.P. and Laishram, "Nuclear Phosphatidylinositol-Phosphate Type I Kinase {alpha}-Coupled Star-PAP Polyadenylation Regulates Cell Invasion" [Author Correction]

Correction for A.P. and Laishram, "Nuclear Phosphatidylinositol-Phosphate Type I Kinase {alpha}-Coupled Star-PAP Polyadenylation Regulates Cell Invasion" [Author Correction] Source link

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CSB-Dependent Cyclin-Dependent Kinase 9 Degradation and RNA Polymerase II Phosphorylation during Transcription-Coupled Repair [Research Article]

DNA lesions block cellular processes such as transcription, inducing apoptosis, tissue failures, and premature aging. To counteract the deleterious effects of DNA damage, cells are equipped with various DNA repair...

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Reevaluation of the Role of Extracellular Signal-Regulated Kinase 3 in Perinatal Survival and Postnatal Growth Using New Genetically Engineered Mouse Models [Research Article]

[ad_1] The physiological functions of the atypical mitogen-activated protein kinase extracellular signal-regulated kinase 3 (ERK3) remain poorly characterized. Previous analysis of mice with a targeted insertion of the lacZ reporter...

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Germ Line Deletion Reveals a Nonessential Role of Atypical Mitogen-Activated Protein Kinase 6/Extracellular Signal-Regulated Kinase 3 [Research Article]

[ad_1] Mitogen-activated protein kinase 6/extracellular signal-regulated kinase 3 (MAPK6/ERK3) is an atypical member of the MAPKs. An essential role has been suggested by the perinatal lethal phenotype of ERK3 knockout...

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Abscisic Acid Inhibits Rice Protein Phosphatase PP45 via H2O2 and Relieves Repression of the Ca2+/CaM-Dependent Protein Kinase DMI3

[ad_1] In plants, Ca2+/calmodulin-dependent protein kinase (CCaMK) is a positive regulator of abscisic acid (ABA) responses, including root growth, antioxidant defense, and tolerance of both water stress and oxidative stress....

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Researchers discover origin of resistance to lung cancer

[ad_1] For treating cancer, drugs based on molecules known as tyrosine kinase inhibitors are sometimes used. One such tyrosine kinase inhibitor, called osimertinib, has been used to treat EGFR-mutated lung...

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Bio-Rad launches new digital PCR system and kit for monitoring treatment response in CML patients

[ad_1] Bio-Rad Laboratories, Inc., a global leader of life science research and clinical diagnostic products, today announced that its QXDx AutoDG ddPCR System, which uses Bio-Rad's Droplet Digital PCR technology,...

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