Tag : Kinase

Biology

Priming Phosphorylation of TANK-Binding Kinase 1 by I{kappa}B Kinase {beta} Is Essential in Toll-Like Receptor 3/4 Signaling [Research Article]

Newsemia
TRIF is an essential adaptor for Toll-like receptor 3/4 (TLR3/4) signaling to activate transcription factor interferon regulatory factor 3 (IRF-3). We examined the molecular mechanism...
Pharma / Biotech

Development of a potent and orally active activator of adenosine monophosphate-activated protein kinase (AMPK), ASP4132, as a clinical candidate for the treatment of human cancer.

Newsemia
Related Articles Development of a potent and orally active activator of adenosine monophosphate-activated protein kinase (AMPK), ASP4132, as a clinical candidate for the treatment of...
Biology

Dynamic Phosphorylation and Dephosphorylation of Cyclase-Associated Protein 1 by Antagonistic Signaling through Cyclin-Dependent Kinase 5 and cAMP Are Critical for the Protein Functions in Actin Filament Disassembly and Cell Adhesion [Research Article]

Newsemia
Cyclase-associated protein 1 (CAP1) is a conserved actin-regulating protein that enhances actin filament dynamics and also regulates adhesion in mammalian cells. We previously found that...
Gastroenterology

Safety of Janus Kinase Inhibitors in Patients with Inflammatory Bowel Diseases or Other Immune-mediated Diseases: a Systematic Review and Meta-Analysis

Newsemia
Inhibitors of Janus kinases (JAKs) are being developed for treatment of inflammatory bowel diseases and other immune-mediated diseases. Tofacitinib is effective in treatment of ulcerative...
Latest News

PAK4 Kinase Activity Plays a Crucial Role in the Podosome Ring of Myeloid Cells

Newsemia
Foxall, E; Staszowska, A; Hirvonen, LM; Georgouli, M; Ciccioli, M; Rimmer, A; Williams, L; … Wells, CM; + view all Foxall, E; Staszowska, A; Hirvonen,...
Pharma / Biotech

Pharmacology of tyrosine kinase inhibitors in chronic myeloid leukemia; a clinician's perspective.

Newsemia
Related Articles Pharmacology of tyrosine kinase inhibitors in chronic myeloid leukemia; a clinician’s perspective. Daru. 2020 Jan 03;: Authors: Pushpam D, Bakhshi S Abstract OBJECTIVE:...
Biology

Genetic Analyses of the Arabidopsis ATG1 Kinase Complex Reveal Both Kinase-Dependent and Independent Autophagic Routes during Fixed-Carbon Starvation

Newsemia
Under nutrient and energy-limiting conditions, plants up-regulate sophisticated catabolic pathways such as autophagy to remobilize nutrients and restore energy homeostasis. Autophagic flux is tightly regulated...
Latest News

Irutinib-based therapy provides superior clinical outcomes in majority of CLL patients

Newsemia
The ECOG-ACRIN Cancer Research Group (ECOG-ACRIN) today announced results from an extended follow-up analysis of patients in its randomized Phase 3 clinical trial, E1912. Source...
Latest News

Janus kinase inhibition for autoinflammation in DNASE2 deficiency

Newsemia
Hong, Y; Capitani, M; Murphy, C; Pandey, S; Cavounidis, A; Takeshita, H; Nanthapisal, S; … Brogan, P; + view all Hong, Y; Capitani, M; Murphy,...
Latest News

ICR scientists carry out first comprehensive assessment of chemical probe resources

Newsemia
A new report urges biomedical researchers to use online web resources very carefully, taking into account their complementary benefits and weaknesses, when selecting small-molecule chemical...

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