Tag: Kinase

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New platform prioritizes synergistic drug combinations against SARS-CoV-2

Newsemia
Researchers in the U.S. have used a new web-based platform to help identify synergistic and antagonistic drug combinations and their underlying mechanisms of action in...
Cardiology

Combined effects of AKT serine/threonine kinase 1 polymorphisms and environment on congenital heart disease risk: A case-control study.

Newsemia
Related Articles Combined effects of AKT serine/threonine kinase 1 polymorphisms and environment on congenital heart disease risk: A case-control study. Medicine (Baltimore). 2020 Jun 26;99(26):e20400...
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Structural and functional analysis of the fission yeast Sty1 stress-activated MAP kinase pathway

Newsemia
Wilkinson, Marc G.; (1998) Structural and functional analysis of the fission yeast Sty1 stress-activated MAP kinase pathway. Doctoral thesis (Ph.D), UCL (University College London). Green...
Biology

Nocodazole-Induced Expression and Phosphorylation of Anillin and Other Mitotic Proteins Are Decreased in DNA-Dependent Protein Kinase Catalytic Subunit-Deficient Cells and Rescued by Inhibition of the Anaphase-Promoting Complex/Cyclosome with proTAME but Not Apcin [Research Article]

Newsemia
The DNA-dependent protein kinase catalytic subunit (DNA-PKcs) has well-established roles in DNA double-strand break repair, and recently, nonrepair functions have also been reported. To better...
Pharma / Biotech

Pediatric high-grade glioma: aberrant epigenetics and kinase signaling define emerging therapeutic opportunities.

Newsemia
Related Articles Pediatric high-grade glioma: aberrant epigenetics and kinase signaling define emerging therapeutic opportunities. J Neurooncol. 2020 Jun 05;: Authors: Sun Y, Bailey CP, Sadighi...
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New strategy identified to address the underlying cause of LAD1 patients' symptoms

Newsemia
Owing to a rare genetic mutation, individuals with leukocyte adhesion deficiency type 1 (LAD1) experience a suite of symptoms that trace back to an immune...
Gastroenterology

Protein Kinase D1, Reduced in Human Pancreatic Tumors, Increases Secretion of Small Extracellular Vesicles From Cancer Cells That Promote Metastasis to Lung in Mice

Newsemia
Pancreatic tumor cells release extracellular vesicles (sEVs, exosomes) that contain lipids and proteins, RNA, and DNA molecules might promote formation of metastases. It is not...
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Adenosine kinase and adenosine receptors A1 R and A2A R in temporal lobe epilepsy and hippocampal sclerosis and association with risk factors for SUDEP.

Newsemia
Patodia, S; Paradiso, B; Garcia, M; Ellis, M; Diehl, B; Thom, M; Devinsky, O; (2020) Adenosine kinase and adenosine receptors A1 R and A2A R...
Gastroenterology

CME Exam 3: Safety of Janus Kinase Inhibitors in Patients With Inflammatory Bowel Diseases or Other Immune-mediated Diseases: A Systematic Review and Meta-analysis

Newsemia
CME Exam 3: Safety of Janus Kinase Inhibitors in Patients With Inflammatory Bowel Diseases or Other Immune-mediated Diseases: A Systematic Review and Meta-analysis Source link...

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