Kinase – Newsemia

Plasma monitoring of EGFR mutations in NSCLC may help predict resistance to tyrosine kinase inhibitors

NewsemiaMarch 22, 2020

by NewsemiaMarch 22, 2020030

Oncotarget Volume 11, Issue 11 reported that at clinical progression, 64 EGFR T790M plasma positive patients were subjected to second line-treatment with osimertinib and strictly...

Pharma / Biotech

Safety, Pharmacokinetics and Pharmacodynamics of Branebrutinib (BMS-986195), a Covalent, Irreversible Inhibitor of Bruton's Tyrosine Kinase: Randomised Phase I, Placebo-Controlled Trial in Healthy Participants.

NewsemiaMarch 22, 2020

by NewsemiaMarch 22, 2020026

Safety, Pharmacokinetics and Pharmacodynamics of Branebrutinib (BMS-986195), a Covalent, Irreversible Inhibitor of Bruton’s Tyrosine Kinase: Randomised Phase I, Placebo-Controlled Trial in Healthy Participants. Br J...

Biology

A Redox-Sensitive Thiol in Wis1 Modulates the Fission Yeast Mitogen-Activated Protein Kinase Response to H2O2 and Is the Target of a Small Molecule [Research Article]

NewsemiaMarch 21, 2020

by NewsemiaMarch 21, 2020026

Oxidation of a highly conserved cysteine (Cys) residue located in the kinase activation loop of mitogen-activated protein kinase kinases (MAPKK) inactivates mammalian MKK6. This residue...

Biology

The receptor tyrosine kinase Ror is required for dendrite regeneration in <i>Drosophila</i> neurons

NewsemiaMarch 13, 2020

by NewsemiaMarch 13, 2020032

by Derek M. R. Nye, Richard M. Albertson, Alexis T. Weiner, J. Ian Hertzler, Matthew Shorey, Deborah C. I. Goberdhan, Clive Wilson, Kevin A. Janes,...

Biology

A Kinase and a Glycosylase Catabolize Pseudouridine in the Peroxisome to Prevent Toxic Pseudouridine Monophosphate Accumulation

NewsemiaMarch 12, 2020

by NewsemiaMarch 12, 2020042

Pseudouridine () is a frequent nucleoside modification that occurs in both noncoding RNAs and mRNAs. In pseudouridine, C5 of uracil is attached to the Rib...

Latest News

Drugging the catalytically inactive state of RET kinase in RET-rearranged tumors

NewsemiaMarch 11, 2020

by NewsemiaMarch 11, 202004

Plenker, D; Riedel, M; Braegelmann, J; Dammert, MA; Chauhan, R; Knowles, PP; Lorenz, C; … Sos, ML; + view all Plenker, D; Riedel, M; Braegelmann,...

Biology

The CYCLIN-DEPENDENT KINASE Module of the Mediator Complex Promotes Flowering and Reproductive Development in Pea

NewsemiaMarch 9, 2020

by NewsemiaMarch 9, 202008

Control of flowering time has been a major focus of comparative genetic analyses in plant development. This study reports on a forward genetic approach to...

Gastroenterology

Imatinib in combination with phosphoinositol kinase inhibitor buparlisib in patients with gastrointestinal stromal tumour who failed prior therapy with imatinib and sunitinib: a Phase 1b, multicentre study

NewsemiaMarch 9, 2020

by NewsemiaMarch 9, 2020012

Imatinib in combination with phosphoinositol kinase inhibitor buparlisib in patients with gastrointestinal stromal tumour who failed prior therapy with imatinib and sunitinib: a Phase 1b,...

Biology

Metabolite Regulatory Interactions Control Plant Respiratory Metabolism via Target of Rapamycin (TOR) Kinase Activation

NewsemiaMarch 2, 2020

by NewsemiaMarch 2, 202008

Respiration rate measurements provide an important readout of energy expenditure and mitochondrial activity in plant cells during the night. As plants inhabit a changing environment,...

Pharma / Biotech

LC-MS/MS determination of buparlisib, a phosphoinositide 3 kinase inhibitor in rat plasma: application to a pharmacokinetic study.

NewsemiaMarch 1, 2020

by NewsemiaMarch 1, 2020038

Related Articles LC-MS/MS determination of buparlisib, a phosphoinositide 3 kinase inhibitor in rat plasma: application to a pharmacokinetic study. Biomed Chromatogr. 2020 Feb 28;:e4816 Authors:...

Cardiology

Salt-inducible kinase 1 maintains HDAC7 stability to promote pathologic cardiac remodeling.

NewsemiaFebruary 28, 2020

by NewsemiaFebruary 28, 2020021

Salt-inducible kinase 1 maintains HDAC7 stability to promote pathologic cardiac remodeling. J Clin Invest. 2020 Feb 27;: Authors: Hsu A, Duan Q, McMahon S, Huang...

Latest News

Prolonged exposure to a pair of antioxidant proteins may fuel liver enlargement

NewsemiaFebruary 25, 2020

by NewsemiaFebruary 25, 2020024

All life is challenged by oxidants — reactive molecules or compounds that remove electrons from other molecules — often with adverse effect, commonly referred to...

Biology

Priming Phosphorylation of TANK-Binding Kinase 1 by I{kappa}B Kinase {beta} Is Essential in Toll-Like Receptor 3/4 Signaling [Research Article]

NewsemiaFebruary 13, 2020

by NewsemiaFebruary 13, 2020038

TRIF is an essential adaptor for Toll-like receptor 3/4 (TLR3/4) signaling to activate transcription factor interferon regulatory factor 3 (IRF-3). We examined the molecular mechanism...

Pharma / Biotech

Development of a potent and orally active activator of adenosine monophosphate-activated protein kinase (AMPK), ASP4132, as a clinical candidate for the treatment of human cancer.

NewsemiaFebruary 5, 2020

by NewsemiaFebruary 5, 2020012

Related Articles Development of a potent and orally active activator of adenosine monophosphate-activated protein kinase (AMPK), ASP4132, as a clinical candidate for the treatment of...

Biology

Dynamic Phosphorylation and Dephosphorylation of Cyclase-Associated Protein 1 by Antagonistic Signaling through Cyclin-Dependent Kinase 5 and cAMP Are Critical for the Protein Functions in Actin Filament Disassembly and Cell Adhesion [Research Article]

NewsemiaFebruary 3, 2020

by NewsemiaFebruary 3, 2020033

Cyclase-associated protein 1 (CAP1) is a conserved actin-regulating protein that enhances actin filament dynamics and also regulates adhesion in mammalian cells. We previously found that...

Latest News

PerkinElmer provides newborn screening assay for PPMD’s New York State pilot program

NewsemiaJanuary 14, 2020

by NewsemiaJanuary 14, 202006

PerkinElmer, Inc., a global leader committed to innovating for a healthier world, today announced that it is providing the newborn screening assay for Parent Project...

Gastroenterology

Safety of Janus Kinase Inhibitors in Patients with Inflammatory Bowel Diseases or Other Immune-mediated Diseases: a Systematic Review and Meta-Analysis

NewsemiaJanuary 10, 2020

by NewsemiaJanuary 10, 2020037

Inhibitors of Janus kinases (JAKs) are being developed for treatment of inflammatory bowel diseases and other immune-mediated diseases. Tofacitinib is effective in treatment of ulcerative...

Latest News

PAK4 Kinase Activity Plays a Crucial Role in the Podosome Ring of Myeloid Cells

NewsemiaJanuary 6, 2020

by NewsemiaJanuary 6, 2020022

Foxall, E; Staszowska, A; Hirvonen, LM; Georgouli, M; Ciccioli, M; Rimmer, A; Williams, L; … Wells, CM; + view all Foxall, E; Staszowska, A; Hirvonen,...

Pharma / Biotech

Pharmacology of tyrosine kinase inhibitors in chronic myeloid leukemia; a clinician's perspective.

NewsemiaJanuary 5, 2020

by NewsemiaJanuary 5, 2020014

Related Articles Pharmacology of tyrosine kinase inhibitors in chronic myeloid leukemia; a clinician’s perspective. Daru. 2020 Jan 03;: Authors: Pushpam D, Bakhshi S Abstract OBJECTIVE:...

Biology

Dual Activities of Plant cGMP-Dependent Protein Kinase and Its Roles in Gibberellin Signaling and Salt Stress

NewsemiaDecember 31, 2019

by NewsemiaDecember 31, 201908

Cyclic GMP (cGMP) is an important regulator in eukaryotes, and cGMP-dependent protein kinase (PKG) plays a key role in perceiving cellular cGMP in diverse physiological...