Kinase

Salt Enhances Disease Resistance and Suppresses Cell Death in Ceramide Kinase Mutants

Sphingolipids act as structural components of cellular membranes and as signals in a variety of plant developmental processes and defense responses, including programmed cell death. Recent studies have uncovered an...

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WEE1 kinase inhibitor shows promise

WEE1 kinase inhibitor shows promise Source link

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Systematic gene silencing identified Cryptosporidium nucleoside diphosphate kinase and other molecules as targets for suppression of parasite proliferation in human intestinal cells

Systematic gene silencing identified Cryptosporidium nucleoside diphosphate kinase and other molecules as targets for suppression of parasite proliferation in human intestinal cells Source link

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Lipid signaling pathway may enhance T cell-mediated immunotherapy

The immune system surveils our body looking for things that don't belong, often bacteria and viruses. While cancer cells are abnormal cells that undergo unregulated cell growth, they are good...

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Targeted pancreatic cancer drug shows promise in clinical trials

Researchers have conducted clinical trials with a new drug targeting pancreatic cancer and the initial results are promising. Source link

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Researchers find new target for disease of the heart's smallest blood vessels

When we race walk, for example, part of our healthy heart muscle may want a little more blood and oxygen, so our tiniest blood vessels send a message upstream to...

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LTK is an ER-resident receptor tyrosine kinase that regulates secretion

The endoplasmic reticulum (ER) is a key regulator of cellular proteostasis because it controls folding, sorting, and degradation of secretory proteins. Much has been learned about how environmentally triggered signaling...

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Discovery of protective protein could open door to better treatment of fast-growing cancer cells

The discovery that an essential protein plays a protective role during cell division, could open the door to better targeted treatment of fast-growing cancer cells. Source link

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Researchers identify toxin responsible for Legionella growth

Pneumonia resulting from exposure to Legionella - although uncommon and affecting only 1 in 100,000 in Europe - has a higher than 10% fatality rate. Source link

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Thylakoid Protein Phosphorylation Dynamics in a Moss Mutant Lacking SERINE/THREONINE PROTEIN KINASE STN8

In all eukaryotes, protein phosphorylation is a key regulatory mechanism in several cellular processes, including the acclimation of photosynthesis to environmental cues. Despite being a well-conserved regulatory mechanism in the...

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Cell Cycle Kinase Polo Is Controlled by a Widespread 3' Untranslated Region Regulatory Sequence in Drosophila melanogaster [Research Article]

Alternative polyadenylation generates transcriptomic diversity, although the physiological impact and regulatory mechanisms involved are still poorly understood. The cell cycle kinase Polo is controlled by alternative polyadenylation in the 3'...

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Selective Kinase Inhibition Shows That Bur1 (Cdk9) Phosphorylates the Rpb1 Linker In Vivo [Research Article]

Cyclin-dependent kinases play multiple roles in RNA polymerase II transcription. Cdk7/Kin28, Cdk9/Bur1, and Cdk12/Ctk1 phosphorylate the polymerase and other factors to drive the dynamic exchange of initiation and elongation complex...

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Neuropathy with vascular endothelial growth factor receptor tyrosine kinase inhibitors: A meta-analysis

Objective To explore the association of peripheral neuropathy with vascular endothelial growth factor receptor tyrosine kinase inhibitors (VEGFR-TKIs) use in patients with cancer. Methods Published data search up to November...

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Histomorphology of pancreatic cancer in patients with inherited ATM serine/threonine kinase pathogenic variants

Histomorphology of pancreatic cancer in patients with inherited ATM serine/threonine kinase pathogenic variants Source link

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Scientists uncover new pathway to make cancers self-destruct

For years, researchers have been trying to target a gene called MYC that is known to drive tumor growth in multiple cancer types when it is mutated or over-expressed, but...

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Unexpected mechanism allows a protein kinase to decode calcium signaling in the brain

A new study from researchers at Max Planck Florida Institute for Neuroscience (MPFI) has shed light on the unexpected mechanism that allows calcium/calmodulin-dependent protein kinase, or CaMKII, to decode and...

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UAB scientists identify new target for drug intervention in Alzheimer's disease

Scientists at the University of Alabama at Birmingham have identified an enzyme in the brain that may be an intriguing target for interventions against Alzheimer's disease and other dementias. Source...

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Evolution of protein kinase substrate recognition at the active site

by David Bradley, Pedro Beltrao Protein kinases catalyse the phosphorylation of target proteins, controlling most cellular processes. The specificity of serine/threonine kinases is partly determined by interactions with a few...

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Researchers identify enzymes that protect people from diabetic kidney disease

A new study from Joslin Diabetes Center has proven that certain biological protective factors play a large role in preventing diabetic kidney disease in certain people. The study was published...

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Rice qGL3/OsPPKL1 Functions with the GSK3/SHAGGY-Like Kinase OsGSK3 to Modulate Brassinosteroid Signaling

Brassinosteroids (BRs) are steroid hormones that play essential roles in plant growth and development. We previously cloned qGL3, a major quantitative trait locus regulating grain length in rice (Oryza sativa)....

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