Kinase – Newsemia

Priming Phosphorylation of TANK-Binding Kinase 1 by I{kappa}B Kinase {beta} Is Essential in Toll-Like Receptor 3/4 Signaling [Research Article]

NewsemiaFebruary 13, 2020

by NewsemiaFebruary 13, 2020031

TRIF is an essential adaptor for Toll-like receptor 3/4 (TLR3/4) signaling to activate transcription factor interferon regulatory factor 3 (IRF-3). We examined the molecular mechanism...

Pharma / Biotech

Development of a potent and orally active activator of adenosine monophosphate-activated protein kinase (AMPK), ASP4132, as a clinical candidate for the treatment of human cancer.

NewsemiaFebruary 5, 2020

by NewsemiaFebruary 5, 202009

Related Articles Development of a potent and orally active activator of adenosine monophosphate-activated protein kinase (AMPK), ASP4132, as a clinical candidate for the treatment of...

Biology

Dynamic Phosphorylation and Dephosphorylation of Cyclase-Associated Protein 1 by Antagonistic Signaling through Cyclin-Dependent Kinase 5 and cAMP Are Critical for the Protein Functions in Actin Filament Disassembly and Cell Adhesion [Research Article]

NewsemiaFebruary 3, 2020

by NewsemiaFebruary 3, 2020024

Cyclase-associated protein 1 (CAP1) is a conserved actin-regulating protein that enhances actin filament dynamics and also regulates adhesion in mammalian cells. We previously found that...

Latest News

PerkinElmer provides newborn screening assay for PPMD’s New York State pilot program

NewsemiaJanuary 14, 2020

by NewsemiaJanuary 14, 202005

PerkinElmer, Inc., a global leader committed to innovating for a healthier world, today announced that it is providing the newborn screening assay for Parent Project...

Gastroenterology

Safety of Janus Kinase Inhibitors in Patients with Inflammatory Bowel Diseases or Other Immune-mediated Diseases: a Systematic Review and Meta-Analysis

NewsemiaJanuary 10, 2020

by NewsemiaJanuary 10, 2020037

Inhibitors of Janus kinases (JAKs) are being developed for treatment of inflammatory bowel diseases and other immune-mediated diseases. Tofacitinib is effective in treatment of ulcerative...

Latest News

PAK4 Kinase Activity Plays a Crucial Role in the Podosome Ring of Myeloid Cells

NewsemiaJanuary 6, 2020

by NewsemiaJanuary 6, 2020019

Foxall, E; Staszowska, A; Hirvonen, LM; Georgouli, M; Ciccioli, M; Rimmer, A; Williams, L; … Wells, CM; + view all Foxall, E; Staszowska, A; Hirvonen,...

Pharma / Biotech

Pharmacology of tyrosine kinase inhibitors in chronic myeloid leukemia; a clinician's perspective.

NewsemiaJanuary 5, 2020

by NewsemiaJanuary 5, 2020013

Related Articles Pharmacology of tyrosine kinase inhibitors in chronic myeloid leukemia; a clinician’s perspective. Daru. 2020 Jan 03;: Authors: Pushpam D, Bakhshi S Abstract OBJECTIVE:...

Biology

Dual Activities of Plant cGMP-Dependent Protein Kinase and Its Roles in Gibberellin Signaling and Salt Stress

NewsemiaDecember 31, 2019

by NewsemiaDecember 31, 201908

Cyclic GMP (cGMP) is an important regulator in eukaryotes, and cGMP-dependent protein kinase (PKG) plays a key role in perceiving cellular cGMP in diverse physiological...

Biology

A Structurally-Validated Multiple Sequence Alignment of 497 Human Protein Kinase Domains

NewsemiaDecember 26, 2019

by NewsemiaDecember 26, 201902

A Structurally-Validated Multiple Sequence Alignment of 497 Human Protein Kinase Domains Source link...

Latest News

Immunologists discover new RIPK1 mechanism that leads to cell death

NewsemiaDecember 24, 2019

by NewsemiaDecember 24, 201900

Scientists at St. Jude Children’s Research Hospital have discovered a new way that the molecule RIPK1 leads to cell death in infected, damaged or unwanted...

Neurology

A rare PANK2 deletion in the first north African patient affected with pantothenate kinase associated neurodegeneration

NewsemiaDecember 21, 2019

by NewsemiaDecember 21, 201900

Neurodegeneration with brain iron accumulation (NBIA) disorders are a heterogeneous set of inherited, rare and clinically diverse neurological diseases often characterised by neuropathology of the...

Gastroenterology

Nerve growth factor and Tropomyosin receptor kinase A are increased in the gastric mucosa of patients with functional dyspepsia

NewsemiaDecember 20, 2019

by NewsemiaDecember 20, 201900

Nerve growth factor (NGF) and enteric glial cells (EGCs) are associated with visceral hypersensitivity and gastrointestinal motility disorder, which may represent the pathogenesis of functional...

Biology

Genetic Analyses of the Arabidopsis ATG1 Kinase Complex Reveal Both Kinase-Dependent and Independent Autophagic Routes during Fixed-Carbon Starvation

NewsemiaDecember 13, 2019

by NewsemiaDecember 13, 201900

Under nutrient and energy-limiting conditions, plants up-regulate sophisticated catabolic pathways such as autophagy to remobilize nutrients and restore energy homeostasis. Autophagic flux is tightly regulated...

Latest News

Irutinib-based therapy provides superior clinical outcomes in majority of CLL patients

NewsemiaDecember 9, 2019

by NewsemiaDecember 9, 201900

The ECOG-ACRIN Cancer Research Group (ECOG-ACRIN) today announced results from an extended follow-up analysis of patients in its randomized Phase 3 clinical trial, E1912. Source...

Biology

Identification of the Arabidopsis Calmodulin-Dependent NAD+ Kinase That Sustains the Elicitor-Induced Oxidative Burst

NewsemiaDecember 8, 2019

by NewsemiaDecember 8, 201900

NADP(H) is an essential cofactor of multiple metabolic processes in all living organisms, and in plants, NADP(H) is required as the substrate of Ca2+-dependent NADPH...

AI/ML

HKPocket: human kinase pocket database for drug design

NewsemiaDecember 3, 2019

by NewsemiaDecember 3, 201900

The kinase pocket structural information is important for drug discovery targeting cancer or other diseases. Although some kinase sequence, structure or drug databases have been...

Latest News

Janus kinase inhibition for autoinflammation in DNASE2 deficiency

NewsemiaDecember 3, 2019

by NewsemiaDecember 3, 201900

Hong, Y; Capitani, M; Murphy, C; Pandey, S; Cavounidis, A; Takeshita, H; Nanthapisal, S; … Brogan, P; + view all Hong, Y; Capitani, M; Murphy,...

Biology

HDAC4 and 5 repression of TBX5 is relieved by protein kinase D1

NewsemiaDecember 1, 2019

by NewsemiaDecember 1, 201901

HDAC4 and 5 repression of TBX5 is relieved by protein kinase D1 Source link...

Latest News

ICR scientists carry out first comprehensive assessment of chemical probe resources

NewsemiaNovember 29, 2019

by NewsemiaNovember 29, 201900

A new report urges biomedical researchers to use online web resources very carefully, taking into account their complementary benefits and weaknesses, when selecting small-molecule chemical...

Biology

JASPer controls interphase histone H3S10 phosphorylation by chromosomal kinase JIL-1 in Drosophila

NewsemiaNovember 27, 2019

by NewsemiaNovember 27, 201900

JASPer controls interphase histone H3S10 phosphorylation by chromosomal kinase JIL-1 in Drosophila Source link...