Kinase – Newsemia

Genetic Analyses of the Arabidopsis ATG1 Kinase Complex Reveal Both Kinase-Dependent and Independent Autophagic Routes during Fixed-Carbon Starvation

NewsemiaDecember 13, 2019

by NewsemiaDecember 13, 201900

Under nutrient and energy-limiting conditions, plants up-regulate sophisticated catabolic pathways such as autophagy to remobilize nutrients and restore energy homeostasis. Autophagic flux is tightly regulated...

Latest News

Irutinib-based therapy provides superior clinical outcomes in majority of CLL patients

NewsemiaDecember 9, 2019

by NewsemiaDecember 9, 201900

The ECOG-ACRIN Cancer Research Group (ECOG-ACRIN) today announced results from an extended follow-up analysis of patients in its randomized Phase 3 clinical trial, E1912. Source...

Biology

Identification of the Arabidopsis Calmodulin-Dependent NAD+ Kinase That Sustains the Elicitor-Induced Oxidative Burst

NewsemiaDecember 8, 2019

by NewsemiaDecember 8, 201900

NADP(H) is an essential cofactor of multiple metabolic processes in all living organisms, and in plants, NADP(H) is required as the substrate of Ca2+-dependent NADPH...

AI/ML

HKPocket: human kinase pocket database for drug design

NewsemiaDecember 3, 2019

by NewsemiaDecember 3, 201900

The kinase pocket structural information is important for drug discovery targeting cancer or other diseases. Although some kinase sequence, structure or drug databases have been...

Latest News

Janus kinase inhibition for autoinflammation in DNASE2 deficiency

NewsemiaDecember 3, 2019

by NewsemiaDecember 3, 201900

Hong, Y; Capitani, M; Murphy, C; Pandey, S; Cavounidis, A; Takeshita, H; Nanthapisal, S; … Brogan, P; + view all Hong, Y; Capitani, M; Murphy,...

Biology

HDAC4 and 5 repression of TBX5 is relieved by protein kinase D1

NewsemiaDecember 1, 2019

by NewsemiaDecember 1, 201900

HDAC4 and 5 repression of TBX5 is relieved by protein kinase D1 Source link...

Latest News

ICR scientists carry out first comprehensive assessment of chemical probe resources

NewsemiaNovember 29, 2019

by NewsemiaNovember 29, 201900

A new report urges biomedical researchers to use online web resources very carefully, taking into account their complementary benefits and weaknesses, when selecting small-molecule chemical...

Biology

JASPer controls interphase histone H3S10 phosphorylation by chromosomal kinase JIL-1 in Drosophila

NewsemiaNovember 27, 2019

by NewsemiaNovember 27, 201900

JASPer controls interphase histone H3S10 phosphorylation by chromosomal kinase JIL-1 in Drosophila Source link...

Biology

Integrin-linked kinase controls retinal angiogenesis and is linked to Wnt signaling and exudative vitreoretinopathy

NewsemiaNovember 21, 2019

by NewsemiaNovember 21, 201900

Integrin-linked kinase controls retinal angiogenesis and is linked to Wnt signaling and exudative vitreoretinopathy Source link...

Biology

CASE PhD studentship: Intercepting CLAVATA receptor-like kinase function to engineer ear size in wheat

NewsemiaNovember 18, 2019

by NewsemiaNovember 18, 201900

Supervisors: Jill Harrison, Keith Edwards and Chris Burt (RAGT Seeds) Project Description Summary: Ensuring continuous global food security will be a major challenge of the...

Pharma / Biotech

A phase 1 dose-escalation study of checkpoint kinase 1 (CHK1) inhibitor prexasertib in combination with p38 mitogen-activated protein kinase (p38 MAPK) inhibitor ralimetinib in patients with advanced or metastatic cancer.

NewsemiaNovember 12, 2019

by NewsemiaNovember 12, 201900

Related Articles A phase 1 dose-escalation study of checkpoint kinase 1 (CHK1) inhibitor prexasertib in combination with p38 mitogen-activated protein kinase (p38 MAPK) inhibitor ralimetinib...

Biology

Redox-Mediated Endocytosis of a Receptor-Like Kinase during Distal Stem Cell Differentiation Depends on Its Tumor Necrosis Factor Receptor Domain

NewsemiaNovember 6, 2019

by NewsemiaNovember 6, 201900

Cellular redox status plays critical roles in cell division and differentiation, but the underlying mechanism is unclear. Here we explored the effect of redox status...

Biology

Atypical Receptor Kinase RINRK1 Required for Rhizobial Infection But Not Nodule Development in Lotus japonicus

NewsemiaOctober 31, 2019

by NewsemiaOctober 31, 201900

During the legume-rhizobium symbiotic interaction, rhizobial invasion of legumes is primarily mediated by a plant-made tubular invagination called an infection thread (IT). Here, we identify...

Latest News

New cellular immunotherapy for cancers

NewsemiaOctober 26, 2019

by NewsemiaOctober 26, 201900

A new study published in the journal Nature Communications on 22 October 2019 reports a new approach to cancer treatment that increases the immune capability...

Biology

Correction of Glycogen Synthase Kinase 3{beta} in Myotonic Dystrophy 1 Reduces the Mutant RNA and Improves Postnatal Survival of DMSXL Mice [Research Article]

NewsemiaOctober 25, 2019

by NewsemiaOctober 25, 201900

Myotonic dystrophy type 1 (DM1) is a multisystem neuromuscular disease without cure. One of the possible therapeutic approaches for DM1 is correction of the RNA-binding...

Biology

Enrichment of Aurora B kinase at the inner kinetochore controls outer kinetochore assembly

NewsemiaOctober 19, 2019

by NewsemiaOctober 19, 201900

Outer kinetochore assembly enables chromosome attachment to microtubules and spindle assembly checkpoint (SAC) signaling in mitosis. Aurora B kinase controls kinetochore assembly by phosphorylating the...

Biology

Aurora B kinase activity is regulated by SET/TAF1 on Sgo2 at the inner centromere

NewsemiaOctober 18, 2019

by NewsemiaOctober 18, 201900

The accurate regulation of phosphorylation at the kinetochore is essential for establishing chromosome bi-orientation. Phosphorylation of kinetochore proteins by the Aurora B kinase destabilizes improper...

Latest News

Newly synthesized anticancer compound can block cancer signaling mechanism

NewsemiaSeptember 24, 2019

by NewsemiaSeptember 24, 201900

Of the various different functions that proteins perform in a cell, a crucial one is the recognition and transmission of certain “signals,” collectively referred to...

Pharma / Biotech

Hypoxia-selective radiosensitisation by SN38023, a bioreductive prodrug of DNA-dependent protein kinase inhibitor IC87361.

NewsemiaSeptember 22, 2019

by NewsemiaSeptember 22, 201900

Related Articles Hypoxia-selective radiosensitisation by SN38023, a bioreductive prodrug of DNA-dependent protein kinase inhibitor IC87361. Biochem Pharmacol. 2019 Sep 18;:113641 Authors: Wong WW, Jackson RK,...

Biology

Mutual Regulation of Receptor-Like Kinase SIT1 and B'{kappa}-PP2A Shapes the Early Response of Rice to Salt Stress

NewsemiaSeptember 19, 2019

by NewsemiaSeptember 19, 201900

The receptor-like kinase SIT1 acts as a sensor in rice (Oryza sativa) roots, relaying salt stress signals via elevated kinase activity to enhance salt sensitivity....