Kinase

PUMPKIN, the Sole Plastid UMP Kinase, Associates with Group II Introns and Alters Their Metabolism

[ad_1] The chloroplast hosts photosynthesis and a variety of metabolic pathways that are essential for plant viability and acclimation processes. In this study, we show that the sole plastid UMP...

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Researchers identify promising therapeutic option to treat multiple sclerosis

[ad_1] With funding provided by the German Research Foundation for the Collaborative Research Center/Transregio 128, researchers at the Medical Center of Johannes Gutenberg University Mainz (JGU) identified an innovative and...

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Hypoxia Restrains Lipid Utilization via Protein Kinase A and Adipose Triglyceride Lipase Downregulation through Hypoxia-Inducible Factor [Research Article]

[ad_1] Oxygen is a key molecule for efficient energy production in living organisms. Although aerobic organisms have adaptive processes to survive in low-oxygen environments, it is poorly understood how lipolysis,...

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A high-performance liquid chromatography-tandem mass spectrometry method for the determination of lifrafenib, a novel RAF kinase and EGFR inhibitor, in human plasma and urine and its application in clinical pharmacokinetic study.

[ad_1] Related Articles A high-performance liquid chromatography-tandem mass spectrometry method for the determination of lifrafenib, a novel RAF kinase and EGFR inhibitor, in human plasma and urine and its application...

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Efficient Replication of the Plastid Genome Requires an Organellar Thymidine Kinase

[ad_1] Thymidine kinase (TK) is a key enzyme of the salvage pathway that recycles thymidine nucleosides to produce deoxythymidine triphosphate. Here, we identified the single TK of maize (Zea mays),...

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A Temperature-Sensitive Misfolded bri1-301 Receptor Requires Its Kinase Activity to Promote Growth

[ad_1] BRASSINOSTEROID-INSENSITIVE1 (BRI1) is a leucine-rich-repeat receptor-like kinase that functions as the cell surface receptor for brassinosteroids (BRs). Previous studies showed that BRI1 requires its kinase activity to transduce the...

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Statins associated with low risk of side effects

[ad_1] The cholesterol-lowering drugs called statins have demonstrated substantial benefits in reducing the risk of heart attacks and strokes caused by blood clots (ischemic strokes) in at-risk patients. Source link...

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Researchers report novel findings on plant hormone

[ad_1] Jasmonic acid is not just the aromatic odor of the plant Jasminum grandiflorum used in cosmetics and perfume industries. Plants wounded by e.g. chewing herbivores produce jasmonic acid as...

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The diacylglycerol kinase α (DGKα)/Akt/NF-κB feedforward loop promotes esophageal squamous cell carcinoma (ESCC) progression via FAK-dependent and FAK-independent manner

[ad_1] The diacylglycerol kinase α (DGKα)/Akt/NF-κB feedforward loop promotes esophageal squamous cell carcinoma (ESCC) progression via FAK-dependent and FAK-independent manner Source link [ad_1]

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MKK6 Functions in Two Parallel MAP Kinase Cascades in Immune Signaling

[ad_1] Arabidopsis (Arabidopsis thaliana) MAP KINASE (MPK) proteins can function in multiple MAP kinase cascades and physiological processes. For instance, MPK4 functions in regulating development as well as in plant...

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Expression of the Alternative Oxidase Influences Jun N-Terminal Kinase Signaling and Cell Migration [Research Article]

[ad_1] Downregulation of Jun N-terminal kinase (JNK) signaling inhibits cell migration in diverse model systems. In Drosophila pupal development, attenuated JNK signaling in the thoracic dorsal epithelium leads to defective...

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Hsp70 Interacts with Mitogen-Activated Protein Kinase (MAPK)-Activated Protein Kinase 2 To Regulate p38MAPK Stability and Myoblast Differentiation during Skeletal Muscle Regeneration [Research Article]

[ad_1] The regenerative process of injured muscle is dependent on the fusion and differentiation of myoblasts derived from muscle stem cells. Hsp70 is important for maintaining skeletal muscle homeostasis and...

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ALS-associated missense and nonsense TBK1 mutations can both cause loss of kinase function

[ad_1] de Majo, M; Topp, SD; Smith, BN; Nishimura, AL; Chen, H-J; Gkazi, AS; Miller, J; ... Shaw, CE; + view all de Majo, M; Topp, SD; Smith, BN; Nishimura,...

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FDA grants accelerated approval to oncology drug for treatment of key genetic driver of cancer

[ad_1] The U.S. Food and Drug Administration today granted accelerated approval to Vitrakvi (larotrectinib), a treatment for adult and pediatric patients whose cancers have a specific genetic feature (biomarker). Source...

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Development of Inflammatory Immune Response-Related Drugs Based on G Protein-Coupled Receptor Kinase 2.

[ad_1] Related Articles Development of Inflammatory Immune Response-Related Drugs Based on G Protein-Coupled Receptor Kinase 2. Cell Physiol Biochem. 2018 Nov 21;51(2):729-745 Authors: Han C, Li Y, Wang Y, Cui...

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Scientists identify novel target for neuron regeneration, functional recovery in spinal cord injury

[ad_1] Restoring the ability to walk following spinal cord injury requires neurons in the brain to reestablish communication pathways with neurons in the spinal cord. Source link [ad_2]

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Adaptation to Endoplasmic Reticulum Stress Requires Transphosphorylation within the Activation Loop of Protein Kinases Kin1 and Kin2, Orthologs of Human Microtubule Affinity-Regulating Kinase [Research Article]

[ad_1] Perturbations in endoplasmic reticulum (ER) homeostasis, a condition termed ER stress, activate the unfolded protein response (UPR), an intracellular network of signaling pathways. Recently, we have shown that protein...

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An International Delphi Survey for the Definition of New Classification Criteria for Familial Mediterranean Fever, Mevalonate Kinase Deficiency, TNF Receptor-associated Periodic Fever Syndromes, and Cryopyrin-associated Periodic Syndrome

[ad_1] Federici, S; Vanoni, F; Ben-Chetrit, E; Cantarini, L; Frenkel, J; Goldbach-Mansky, R; Gul, A; ... Pediatric Rheumatology International Trials Organization(PRINTO), .; + view all Federici, S; Vanoni, F; Ben-Chetrit,...

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Protein Kinase C Binding Protein 1(PRKCBP1) Inhibits Hypoxia Inducible Factor 1 (HIF-1) in the Heart.

[ad_1] Related Articles Protein Kinase C Binding Protein 1(PRKCBP1) Inhibits Hypoxia Inducible Factor 1 (HIF-1) in the Heart. Cardiovasc Res. 2018 Nov 05;: Authors: Schunke KJ, Walton CB, Veal DR,...

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FDA approves LORBRENA for treatment of patients with ALK-positive metastatic NSCLC

[ad_1] Pfizer Inc. today announced that the U.S. Food and Drug Administration has approved LORBRENA, a third-generation anaplastic lymphoma kinase tyrosine kinase inhibitor for patients with ALK-positive metastatic non-small cell...

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