Tag : inhibitors

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Plasma monitoring of EGFR mutations in NSCLC may help predict resistance to tyrosine kinase inhibitors

Newsemia
Oncotarget Volume 11, Issue 11 reported that at clinical progression, 64 EGFR T790M plasma positive patients were subjected to second line-treatment with osimertinib and strictly...
Gastroenterology

Real-world effectiveness and safety of sofosbuvir and nonstructural protein 5A inhibitors for chronic hepatitis C genotype 1, 2, 3, 4, or 6: a multicentre cohort study

Newsemia
We investigated real-world effectiveness and safety of sofosbuvir and the nonstructural protein 5A inhibitors in the treatment of patients infected with hepatitis C virus (HCV)...
Pharma / Biotech

Skeletal restoration by phosphodiesterase 5 inhibitors in osteopenic mice: Evidence of osteoanabolic and osteoangiogenic effects of the drugs.

Newsemia
Related Articles Skeletal restoration by phosphodiesterase 5 inhibitors in osteopenic mice: Evidence of osteoanabolic and osteoangiogenic effects of the drugs. Bone. 2020 Feb 29;:115305 Authors:...
Cardiology

Aromatase Inhibitors and the Risk of Cardiovascular Outcomes in Women With Breast Cancer: A Population-Based Cohort Study.

Newsemia
Aromatase Inhibitors and the Risk of Cardiovascular Outcomes in Women With Breast Cancer: A Population-Based Cohort Study. Circulation. 2020 Feb 18;141(7):549-559 Authors: Khosrow-Khavar F, Filion...
Latest News

Comparative cardiovascular risk in users versus non-users of xanthine oxidase inhibitors and febuxostat versus allopurinol users

Newsemia
Ju, C; Lai, RWC; Li, KHC; Hung, JKF; Lai, JCL; Ho, J; Liu, Y; … Tse, G; + view all Ju, C; Lai, RWC; Li,...
Pharma / Biotech

Structure-guided screening of chemical database to identify NS3-NS2B inhibitors for effective therapeutic application in dengue infection.

Newsemia
Related Articles Structure-guided screening of chemical database to identify NS3-NS2B inhibitors for effective therapeutic application in dengue infection. J Mol Recognit. 2020 Feb 14;:e2838 Authors:...
Pharma / Biotech

Factor Xa inhibitors in clinical practice: Comparison of pharmacokinetic profiles.

Newsemia
Related Articles Factor Xa inhibitors in clinical practice: Comparison of pharmacokinetic profiles. Drug Metab Pharmacokinet. 2019 Oct 25;: Authors: Goto E, Horinaka S, Ishimitsu T,...
Gastroenterology

6 NOVEL BRD4 INHIBITORS BLOCK THE PATHOLOGICAL ACTIVATION OF BRD4-NFκB SIGNALING AND SUPPRESS COLONIC INFLAMMATION IN IBD MOUSE MODELS

Newsemia
Ulcerative Colitis (UC) and Crohn’s Disease (CD) are two major types of inflammatory bowel disease (IBD), with recurrent symptoms and significant morbidity. Long-term persistence of...
Latest News

Patients with type 2 diabetes can achieve cardiovascular protection from use of SGLT2 inhibitors

Newsemia
All type 2 diabetes patient subgroups are likely to achieve cardiovascular protection from the use of SGLT2 inhibitors, according to a large multi-study review published...
Gastroenterology

P152 EVALUATING THE EFFICACY OF GLUTAMATE CARBOXYPEPTIDASE II (GCPII) INHIBITORS IN “WILD-TYPE” MICE: LESSONS LEARNED FROM THE DEDICATOR OF CYTOKINESIS 2 MUTANT MOUSE

Newsemia
Glutamate carboxypeptidase II (GCPII) is highly upregulated in human IBD and is a therapeutic target under active investigation by our laboratory. We recently published that...

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