Tag : Inhibitor

Gastroenterology

P066 GB004, A NOVEL GUT-TARGETED PROLYL HYDROXYLASE INHIBITOR FOR INFLAMMATORY BOWEL DISEASE: FIRST-IN-HUMAN, MUTLIPLE-DOSE STUDY IN HEALTHY SUBJECTS WITH GUT BIOPSIES

Newsemia
GB004 is a small molecule prolyl hydroxylase inhibitor (PHDi) that stabilizes hypoxia inducible factors (HIF1-α), key transcription factors involved in the protective cellular responses at...
Pharma / Biotech

Imipenem-Cilastatin-Relebactam: A Novel β-Lactam-β-Lactamase Inhibitor Combination for the Treatment of Multidrug-Resistant Gram-Negative Infections.

Newsemia
Related Articles Imipenem-Cilastatin-Relebactam: A Novel β-Lactam-β-Lactamase Inhibitor Combination for the Treatment of Multidrug-Resistant Gram-Negative Infections. Pharmacotherapy. 2020 Feb 15;: Authors: Smith JR, Rybak JM, Claeys...
Cardiology

Long-term clinical outcomes with use of an angiotensin-converting enzyme inhibitor early after heart transplantation.

Newsemia
Related Articles Long-term clinical outcomes with use of an angiotensin-converting enzyme inhibitor early after heart transplantation. Am Heart J. 2020 Jan 09;222:30-37 Authors: Arashi H,...
Cardiology

Cardiovascular complications of anti-cancer immune checkpoint inhibitor therapy and their combinations: are we ready for challenges ahead?

Newsemia
The use of immune checkpoint inhibitors (ICIs) has transformed the treatment landscape for a number of tumour types over the past decade. Targeting cytotoxic T-lymphocyte-associated...
Gastroenterology

Prevalence and predictors of proton pump inhibitor partial response in gastroesophageal reflux disease in systemic sclerosis: a prospective study

Newsemia
Prevalence and predictors of proton pump inhibitor partial response in gastroesophageal reflux disease in systemic sclerosis: a prospective study Source link...
Gastroenterology

Phase 2 study of vismodegib, a hedgehog inhibitor, combined with gemcitabine and nab-paclitaxel in patients with untreated metastatic pancreatic adenocarcinoma

Newsemia
Phase 2 study of vismodegib, a hedgehog inhibitor, combined with gemcitabine and nab-paclitaxel in patients with untreated metastatic pancreatic adenocarcinoma Source link...
Neurology

'Spark of Hope' for Tau Inhibitor in Alzheimer's Disease

Newsemia
Low-dose hydromethylthionine may help prevent both cognitive decline and brain atrophy in early Alzheimer’s disease, new exploratory research suggests. Medscape Medical News Source link...
Gastroenterology

Effects of Belapectin, an Inhibitor of Galectin-3, in Patients with Nonalcoholic Steatohepatitis With Cirrhosis And Portal Hypertension

Newsemia
Increased levels of galectin 3 have been associated with nonalcoholic steatohepatitis (NASH) and contributes to toxin-induced liver fibrosis in mice. GR-MD-02 (belapectin) is an inhibitor...
Pharma / Biotech

Dotinurad: a clinical pharmacokinetic study of a novel, selective urate reabsorption inhibitor in subjects with hepatic impairment.

Newsemia
Related Articles Dotinurad: a clinical pharmacokinetic study of a novel, selective urate reabsorption inhibitor in subjects with hepatic impairment. Clin Exp Nephrol. 2019 Nov 23;:...

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