Tag: inhibition

Pharma / Biotech

Small Molecule Dysregulation of TEAD Lipidation Induces a Dominant-Negative Inhibition of Hippo Pathway Signaling.

Newsemia
Related Articles Small Molecule Dysregulation of TEAD Lipidation Induces a Dominant-Negative Inhibition of Hippo Pathway Signaling. Cell Rep. 2020 Jun 23;31(12):107809 Authors: Holden JK, Crawford...
Biology

Acute inhibition of centriolar satellite function and positioning reveals their functions at the primary cilium

Newsemia
by Özge Z. Aydin, Sevket Onur Taflan, Can Gurkaslar, Elif Nur Firat-Karalar Centriolar satellites are dynamic, membraneless granules composed of over 200 proteins. They store,...
Biology

Nocodazole-Induced Expression and Phosphorylation of Anillin and Other Mitotic Proteins Are Decreased in DNA-Dependent Protein Kinase Catalytic Subunit-Deficient Cells and Rescued by Inhibition of the Anaphase-Promoting Complex/Cyclosome with proTAME but Not Apcin [Research Article]

Newsemia
The DNA-dependent protein kinase catalytic subunit (DNA-PKcs) has well-established roles in DNA double-strand break repair, and recently, nonrepair functions have also been reported. To better...
Cardiology

Inhibition of chymotrypsin-like activity of the proteasome by ixazomib prevents mitochondrial dysfunction during myocardial ischemia.

Newsemia
Related Articles Inhibition of chymotrypsin-like activity of the proteasome by ixazomib prevents mitochondrial dysfunction during myocardial ischemia. PLoS One. 2020;15(5):e0233591 Authors: Sánchez G, Chalmers S,...
Gastroenterology

Hexosamine pathway inhibition overcomes pancreatic cancer resistance to gemcitabine through unfolded protein response and EGFR-Akt pathway modulation

Newsemia
Hexosamine pathway inhibition overcomes pancreatic cancer resistance to gemcitabine through unfolded protein response and EGFR-Akt pathway modulation Source link...
Pharma / Biotech

In vitro inhibition of human cytochrome P450 enzymes by the novel atypical antipsychotic drug asenapine: a prediction of possible drug-drug interactions.

Newsemia
Related Articles In vitro inhibition of human cytochrome P450 enzymes by the novel atypical antipsychotic drug asenapine: a prediction of possible drug-drug interactions. Pharmacol Rep....
Cardiology

Platelet Inhibition in Acute Coronary Syndrome and Percutaneous Coronary Intervention: Insights from the Past and Present.

Newsemia
Related Articles Platelet Inhibition in Acute Coronary Syndrome and Percutaneous Coronary Intervention: Insights from the Past and Present. Thromb Haemost. 2020 Feb 19;: Authors: Gorog...

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