hypercholesterolemia
- December 7, 2019
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- Tags: ClinicallydefinedfamilialFamilial hypercholesterolemia;Family cosegregation;Mutation-negative familial hypercholesterolemia;STAP1hypercholesterolemiaMutationsPathogenicpredictedSTAP1
Related Articles Predicted pathogenic mutations in STAP1 are not associated with clinically defined familial hypercholesterolemia. Atherosclerosis. 2019 Nov 29;292:143-151 Authors: Lamiquiz-Moneo I, Restrepo-Córdoba MA, Mateo-Gallego R, Bea AM, Del Pino...
Read moreReply: Familial Hypercholesterolemia Causes Sudden Death Source link
Read more- December 4, 2019
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- Tags: deathfamilialhypercholesterolemiaSudden
Familial Hypercholesterolemia Causes Sudden Death Source link
Read more- November 27, 2019
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- Tags: ACSacute coronary syndromeacute coronary syndrome (acs)ASCVDatherosclerosisatherosclerotic cardiovascular diseaseatherosclerotic heart diseaseCardiovascularcardiovascular diseclinical guidelinescommoncoronary atherosclerosiscoronary heart diseaseCVdrug (lipid lowering)Goalsguidelineshypercholesterolemiahypertensionischemic heart diseaseLDLClipid lowering drugslipid managementlipidsNhanesPINNACLEStatinUnmet
Two studies of patients with ASCVD -- NHANES and the PINNACLE registry -- show 'a large burden of non- and undertreatment' and 'room for improvement' to lower LDL-C levels, say...
Read more- November 11, 2019
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- Tags: EfficacyEvolocumabhypercholesterolemiaLongTermpatientssafety
AbstractBackground Evolocumab and other anti-PCSK9 antibodies reduced adverse cardiovascular outcomes in clinical trials of high-risk patients over <3 years median treatment duration. Objectives The OSLER-1 trial (Open Label Study of Long...
Read more- November 8, 2019
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- Tags: Dyslipidemia;Hypercholesterolemia;Ischemic heart disease;Nigeria;PrevalencehypercholesterolemiametaanalysisNigeriaprevalenceReviewSystematic
Related Articles Prevalence of hypercholesterolemia in Nigeria: a systematic review and meta-analysis. Public Health. 2019 Nov 04;178:167-178 Authors: Adeloye D, Abaa DQ, Owolabi EO, Ale BM, Mpazanje RG, Dewan MT,...
Read more- November 1, 2019
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- Tags: AcidattenuatesBileGuthypercholesterolemiaMetabolismmicrobiotaModulationPuerhteaTheabrownin
Theabrownin from Pu-erh tea attenuates hypercholesterolemia via modulation of gut microbiota and bile acid metabolism Source link
Read more- October 27, 2019
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- Tags: EfficacyenduringEvolocumabhypercholesterolemiaOSLER1safetytolerabilitytreatmentyears
Evolocumab Treatment of Hypercholesterolemia in OSLER-1: Enduring Efficacy, Tolerability, and Safety Over 5 Years Source link
Read moreImproved low-density lipoprotein levels and reduced cardiovascular event risk were shown after 20 years of statin treatment in children with FH. Source link
Read more- September 7, 2019
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- Tags: AchievementadultamongCardiovascularCardiovascular disease;Familial hypercholesterolemia;LDL cholesterol goal achievement;Low density lipoprotein (LDL) cholesterol;PCSK9 inhibitorcascadecholesterolDensityfamilialFHGoalhypercholesterolemiaLipoproteinlongitudinalOutcomespatientsRegistry
Related Articles Longitudinal low density lipoprotein cholesterol goal achievement and cardiovascular outcomes among adult patients with familial hypercholesterolemia: The CASCADE FH registry. Atherosclerosis. 2019 Aug 19;289:85-93 Authors: Duell PB, Gidding...
Read more- September 5, 2019
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- Tags: attenuatescholesterolFailuregene therapy;heart failure;hypercholesterolemia;oxidative stress;transverse aortic constrictionhearthypercholesterolemiaLoweringmiceMildOverloadInducedpressure
Related Articles Cholesterol lowering attenuates pressure overload-induced heart failure in mice with mild hypercholesterolemia. Aging (Albany NY). 2019 Sep 04;11: Authors: Muthuramu I, Mishra M, Aboumsallem JP, Postnov A, Gheysens...
Read morePolygenic Risk Scores in Familial Hypercholesterolemia Source link
Read more- July 27, 2019
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- Tags: atheroscleroticdiseasefamilialhypercholesterolemiamonogenicpatientsPolygenicPrematurerisk
AbstractBackground A pathogenic variant in LDLR, APOB, or PCSK9 can be identified in 30% to 80% of patients with clinically-diagnosed familial hypercholesterolemia (FH). Alternatively, ~20% of clinical FH is thought...
Read more- July 13, 2019
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- Tags: 039DoubleACSacute coronary syndromeacute coronary syndrome (acs)atherosclerosisCardiovascularCVdiabetes mellitusdiabetes mellitus type 2diabetes mellitus type iiDiabetesACSFithypercholesterolemiainhibitorslipid managementlipidsPCSK9proprotein convertase subtilisin/kexin type 9type 2 diabetesWhammy039
Patients with diabetes as well as ACS and uncontrolled high cholesterol have a "double whammy" that makes them candidates for PCSK9 inhibitors to prevent CV events, says expert. Medscape Medical...
Read more- July 1, 2019
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- Tags: adiposebacteriabacteriumCardiovascularcardiovascular diseasediabetesdrugshypercholesterolemiaInsulinInsulin ResistanceLimitobesitypeoplePlaceboprobioticresearchrisksshowsstudysupplementstype 2 diabetes
In 2007, Patrice Cani (FNRS-WELBIO researcher) and his team at the Louvain Drug Research Institute of University of Louvain, in close collaboration with Willem de Vos, professor at UWageningen, discovered...
Read more- June 25, 2019
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- Tags: Alirocumab;Evolocumab;FH;Familial hypercholesterolemia;LDL-C;ScreenPro FHcooperationfamilialFHhypercholesterolemiaimpactInternationalprojectResultsscreeningScreenProtreatment
The Impact of the International Cooperation On Familial Hypercholesterolemia Screening and Treatment: Results from the ScreenPro FH Project. Curr Atheroscler Rep. 2019 Jun 22;21(9):36 Authors: Ceska R, Latkovskis G, Ezhov...
Read more- May 15, 2019
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- Tags: amongASSESSMENTclockfamilialhypercholesterolemiaInfarctsPrematurestarttime
[ad_1] Hypercholesterolemia Among Premature Infarcts: Time to Start the Clock of Familial Hypercholesterolemia Assessment Source link [ad_2]
Read more- May 15, 2019
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- Tags: Adultsamongfamilialhypercholesterolemiainfarctionmyocardialyoung
[ad_1] AbstractBackground There are limited data on the prevalence and treatment of familial hypercholesterolemia (FH) among U.S. adults who experience a myocardial infarction (MI) at a young age. Objectives This...
Read more[ad_1] (HealthDay)—A machine learning classifier can effectively identify patients at risk for familial hypercholesterolemia (FH), according to a study published online April 11 in npj Digital Medicine. Source link [ad_2]
Read more- March 15, 2019
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- Tags: atherosclerosisbloodbraincardiovascular diseasecholesterolcholesterolloweringcoronary heart diseaseDrugEnzymeheartheart attackheart diseasehypercholesterolemiaLipoproteinlivermedicinemusclePeripheral Arterial DiseasePlaceboStatinstrokeSuccess
[ad_1] A new, oral drug that effectively lowers LDL or "bad" cholesterol, looks set for clinical approval. Source link [ad_2]
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