Tag : Haplotypes

Pharma / Biotech

Next Challenge From the Variance in Individual Physiologically-Based Pharmacokinetic Model-Predicted to Observed Morphine Concentration in Critically Ill Neonates.

Newsemia
Related Articles Next Challenge From the Variance in Individual Physiologically-Based Pharmacokinetic Model-Predicted to Observed Morphine Concentration in Critically Ill Neonates. Clin Pharmacol Ther. 2020 02;107(2):319-320...
Gastroenterology

Underpowered PANTS: a response to the conclusions of “Extended Analysis Identifies Drug-Specific Association of Two Distinct HLA Class II Haplotypes for Development of Immunogenicity to Adalimumab and Infliximab”

Newsemia
Underpowered PANTS: a response to the conclusions of “Extended Analysis Identifies Drug-Specific Association of Two Distinct HLA Class II Haplotypes for Development of Immunogenicity to...
Biology

A comparison of humans and baboons suggests germline mutation rates do not track cell divisions

Newsemia
by Felix L. Wu, Alva I. Strand, Laura A. Cox, Carole Ober, Jeffrey D. Wall, Priya Moorjani, Molly Przeworski In humans, most germline mutations are...
Biology

Haplotype of the astrocytic water channel AQP4 is associated with slow wave energy regulation in human NREM sleep

Newsemia
by Sara Marie Ulv Larsen, Hans-Peter Landolt, Wolfgang Berger, Maiken Nedergaard, Gitte Moos Knudsen, Sebastian Camillo Holst Cerebrospinal fluid (CSF) flow through the brain parenchyma...
Gastroenterology

Extended Analysis Identifies Drug-Specific Association of Two Distinct HLA Class II Haplotypes for Development of Immunogenicity to Adalimumab and Infliximab

Newsemia
Extended Analysis Identifies Drug-Specific Association of Two Distinct HLA Class II Haplotypes for Development of Immunogenicity to Adalimumab and Infliximab Source link...
Gastroenterology

Single-molecular real-time deep sequencing reveals the dynamics of multi-drug resistant haplotypes and structural variations in the hepatitis C virus genome

Newsemia
Single-molecular real-time deep sequencing reveals the dynamics of multi-drug resistant haplotypes and structural variations in the hepatitis C virus genome Source link...
Biology

Inferring the distribution of fitness effects of spontaneous mutations in <i>Chlamydomonas reinhardtii</i>

Newsemia
by Katharina B. Böndel, Susanne A. Kraemer, Toby Samuels, Deirdre McClean, Josianne Lachapelle, Rob W. Ness, Nick Colegrave, Peter D. Keightley Spontaneous mutations are the...
Biology

Genetic redundancy fuels polygenic adaptation in <i>Drosophila</i>

Newsemia
by Neda Barghi, Raymond Tobler, Viola Nolte, Ana Marija Jakšić, François Mallard, Kathrin Anna Otte, Marlies Dolezal, Thomas Taus, Robert Kofler, Christian Schlötterer The genetic...
Biology

QTL mapping of natural variation reveals that the developmental regulator <i>bruno</i> reduces tolerance to <i>P</i>-element transposition in the <i>Drosophila</i> female germline

Newsemia
by Erin S. Kelleher, Jaweria Jaweria, Uchechukwu Akoma, Lily Ortega, Wenpei Tang Transposable elements (TEs) are obligate genetic parasites that propagate in host genomes by...
Latest News

Sixteen diverse laboratory mouse reference genomes define strain-specific haplotypes and novel functional loci

Newsemia
Lilue, J; Doran, AG; Fiddes, IT; Abrudan, M; Armstrong, J; Bennett, R; Chow, W; … Keane, TM; + view all Lilue, J; Doran, AG; Fiddes,...
Biology

Repeated translocation of a gene cassette drives sex-chromosome turnover in strawberries

Newsemia
by Jacob A. Tennessen, Na Wei, Shannon Straub, Rajanikanth Govindarajulu, Aaron Liston, Tia-Lynn Ashman Turnovers of sex-determining systems represent important diversifying forces across eukaryotes. Shifts...

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