Tag : GTPase

Biology

Optogenetics reveals Cdc42 local activation by scaffold-mediated positive feedback and Ras GTPase

Newsemia
by Iker Lamas, Laura Merlini, Aleksandar Vještica, Vincent Vincenzetti, Sophie G. Martin Local activity of the small GTPase Cdc42 is critical for cell polarization. Whereas...
Biology

Allosteric regulation of a prokaryotic small Ras-like GTPase contributes to cell polarity oscillations in bacterial motility

Newsemia
by Jyoti Baranwal, Sébastien Lhospice, Manil Kanade, Sukanya Chakraborty, Priyanka Rajendra Gade, Shrikant Harne, Julien Herrou, Tâm Mignot, Pananghat Gayathri Mutual gliding motility A (MglA),...
Biology

The Inhibitor Endosidin 4 Targets SEC7 Domain-Type ARF GTPase Exchange Factors and Interferes with Subcellular Trafficking in Eukaryotes

Newsemia
The trafficking of subcellular cargos in eukaryotic cells crucially depends on vesicle budding, a process mediated by ARF-GEFs (ADP-ribosylation factor guanine nucleotide exchange factors). In...
Gastroenterology

Overexpression of Rac GTPase activating Protein 1 Contributes to Proliferation of Cancer Cells by Reducing Hippo Signaling to Promote Cytokinesis

Newsemia
Agents designed to block or alter cytokinesis can kill or stop proliferation of cancer cells. We aimed to identify cytokinesis-related proteins that are overexpressed in...

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