Green fluorescent protein

Adult bone marrow progenitors become decidual cells and contribute to embryo implantation and pregnancy

by Reshef Tal, Shafiq Shaikh, Pallavi Pallavi, Aya Tal, Francesc López-Giráldez, Fang Lyu, Yuan-Yuan Fang, Shruti Chinchanikar, Ying Liu, Harvey J. Kliman, Myles Alderman III, Nicola Pluchino, Jehanzeb Kayani, Ramanaiah...

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β-glucan–dependent shuttling of conidia from neutrophils to macrophages occurs during fungal infection establishment

by Vahid Pazhakh, Felix Ellett, Ben A. Croker, Joanne A. O’Donnell, Luke Pase, Keith E. Schulze, R. Stefan Greulich, Aakash Gupta, Constantino Carlos Reyes-Aldasoro, Alex Andrianopoulos, Graham J. Lieschke The...

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Reticulon and CLIMP-63 regulate nanodomain organization of peripheral ER tubules

by Guang Gao, Chengjia Zhu, Emma Liu, Ivan R. Nabi The endoplasmic reticulum (ER) is an expansive, membrane-enclosed organelle composed of smooth peripheral tubules and rough, ribosome-studded central ER sheets...

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Selective suppression and recall of long-term memories in <i>Drosophila</i>

by Dominique Siegenthaler, Benjamin Escribano, Vanessa Bräuler, Jan Pielage Adaptive decision-making depends on the formation of novel memories. In Drosophila, the mushroom body (MB) is the site of associative olfactory...

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MDT-15/MED15 permits longevity at low temperature via enhancing lipidostasis and proteostasis

by Dongyeop Lee, Seon Woo A. An, Yoonji Jung, Yasuyo Yamaoka, Youngjae Ryu, Grace Ying Shyen Goh, Arshia Beigi, Jae-Seong Yang, Gyoo Yeol Jung, Dengke K. Ma, Chang Man Ha,...

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N-terminal β-strand underpins biochemical specialization of an ATG8 isoform

by Erin K. Zess, Cassandra Jensen, Neftaly Cruz-Mireles, Juan Carlos De la Concepcion, Jan Sklenar, Madlen Stephani, Richard Imre, Elisabeth Roitinger, Richard Hughes, Khaoula Belhaj, Karl Mechtler, Frank L. H....

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LATS1/2 suppress NFκB and aberrant EMT initiation to permit pancreatic progenitor differentiation

by Caitlin M. Braitsch, D. Berfin Azizoglu, Yadanar Htike, Haley R. Barlow, Ulrike Schnell, Christopher P. Chaney, Thomas J. Carroll, Ben Z. Stanger, Ondine Cleaver The Hippo pathway directs cell...

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Global proteomic analyses define an environmentally contingent Hsp90 interactome and reveal chaperone-dependent regulation of stress granule proteins and the R2TP complex in a fungal pathogen

by Teresa R. O’Meara, Matthew J. O’Meara, Elizabeth J. Polvi, M. Reza Pourhaghighi, Sean D. Liston, Zhen-Yuan Lin, Amanda O. Veri, Andrew Emili, Anne-Claude Gingras, Leah E. Cowen Hsp90 is...

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DPPA2/4 and SUMO E3 ligase PIAS4 opposingly regulate zygotic transcriptional program

by Yao-Long Yan, Chao Zhang, Jing Hao, Xue-Lian Wang, Jia Ming, Li Mi, Jie Na, Xinli Hu, Yangming Wang The molecular mechanism controlling the zygotic genome activation (ZGA) in mammals...

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Selective use of primate CD4 receptors by HIV-1

by Cody J. Warren, Nicholas R. Meyerson, Obaiah Dirasantha, Emily R. Feldman, Gregory K. Wilkerson, Sara L. Sawyer Individuals chronically infected with HIV-1 harbor complex viral populations within their bloodstreams....

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Rapamycin directly activates lysosomal mucolipin TRP channels independent of mTOR

by Xiaoli Zhang, Wei Chen, Qiong Gao, Junsheng Yang, Xueni Yan, Han Zhao, Lin Su, Meimei Yang, Chenlang Gao, Yao Yao, Ken Inoki, Dan Li, Rong Shao, Shiyi Wang, Nirakar...

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Reversible association with motor proteins (RAMP): A streptavidin-based method to manipulate organelle positioning

by Carlos M. Guardia, Raffaella De Pace, Aritra Sen, Amra Saric, Michal Jarnik, David A. Kolin, Ambarish Kunwar, Juan S. Bonifacino We report the development and characterization of a method,...

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mRNA association by aminoacyl tRNA synthetase occurs at a putative anticodon mimic and autoregulates translation in response to tRNA levels

by Ofri Levi, Yoav Arava Aminoacyl-tRNA synthetases (aaRSs) are well studied for their role in binding and charging tRNAs with cognate amino acids. Recent RNA interactome studies had suggested that...

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Cellular labeling of endogenous retrovirus replication (CLEVR) reveals de novo insertions of the gypsy retrotransposable element in cell culture and in both neurons and glial cells of aging fruit flies

by Yung-Heng Chang, Richard M. Keegan, Lisa Prazak, Josh Dubnau Evidence is rapidly mounting that transposable element (TE) expression and replication may impact biology more widely than previously thought. This...

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Simu-dependent clearance of dying cells regulates macrophage function and inflammation resolution

by Hannah Grace Roddie, Emma Louise Armitage, Jonathon Alexis Coates, Simon Andrew Johnston, Iwan Robert Evans Macrophages encounter and clear apoptotic cells during normal development and homeostasis, including at numerous...

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High-resolution mapping reveals that microniches in the gastric glands control <i>Helicobacter pylori</i> colonization of the stomach

by Connie Fung, Shumin Tan, Mifuyu Nakajima, Emma C. Skoog, Luis Fernando Camarillo-Guerrero, Jessica A. Klein, Trevor D. Lawley, Jay V. Solnick, Tadashi Fukami, Manuel R. Amieva Lifelong infection of...

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Amot and Yap1 regulate neuronal dendritic tree complexity and locomotor coordination in mice

by Katarzyna O. Rojek, Joanna Krzemień, Hubert Doleżyczek, Paweł M. Boguszewski, Leszek Kaczmarek, Witold Konopka, Marcin Rylski, Jacek Jaworski, Lars Holmgren, Tomasz J. Prószyński The angiomotin (Amot)–Yes-associated protein 1 (Yap1)...

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Dhh1 promotes autophagy-related protein translation during nitrogen starvation

by Xu Liu, Zhiyuan Yao, Meiyan Jin, Sim Namkoong, Zhangyuan Yin, Jun Hee Lee, Daniel J. Klionsky Macroautophagy (hereafter autophagy) is a well-conserved cellular process through which cytoplasmic components are...

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Up-regulation of FOXD1 by YAP alleviates senescence and osteoarthritis

by Lina Fu, Yuqiong Hu, Moshi Song, Zunpeng Liu, Weiqi Zhang, Fa-Xing Yu, Jun Wu, Si Wang, Juan Carlos Izpisua Belmonte, Piu Chan, Jing Qu, Fuchou Tang, Guang-Hui Liu Cellular...

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CRISPR screening using an expanded toolkit of autophagy reporters identifies TMEM41B as a novel autophagy factor

by Christopher J. Shoemaker, Tina Q. Huang, Nicholas R. Weir, Nicole Polyakov, Sebastian W. Schultz, Vladimir Denic The power of forward genetics in yeast is the foundation on which the...

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