Green fluorescent protein

DPPA2/4 and SUMO E3 ligase PIAS4 opposingly regulate zygotic transcriptional program

by Yao-Long Yan, Chao Zhang, Jing Hao, Xue-Lian Wang, Jia Ming, Li Mi, Jie Na, Xinli Hu, Yangming Wang The molecular mechanism controlling the zygotic genome activation (ZGA) in mammals...

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Selective use of primate CD4 receptors by HIV-1

by Cody J. Warren, Nicholas R. Meyerson, Obaiah Dirasantha, Emily R. Feldman, Gregory K. Wilkerson, Sara L. Sawyer Individuals chronically infected with HIV-1 harbor complex viral populations within their bloodstreams....

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Rapamycin directly activates lysosomal mucolipin TRP channels independent of mTOR

by Xiaoli Zhang, Wei Chen, Qiong Gao, Junsheng Yang, Xueni Yan, Han Zhao, Lin Su, Meimei Yang, Chenlang Gao, Yao Yao, Ken Inoki, Dan Li, Rong Shao, Shiyi Wang, Nirakar...

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Reversible association with motor proteins (RAMP): A streptavidin-based method to manipulate organelle positioning

by Carlos M. Guardia, Raffaella De Pace, Aritra Sen, Amra Saric, Michal Jarnik, David A. Kolin, Ambarish Kunwar, Juan S. Bonifacino We report the development and characterization of a method,...

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mRNA association by aminoacyl tRNA synthetase occurs at a putative anticodon mimic and autoregulates translation in response to tRNA levels

by Ofri Levi, Yoav Arava Aminoacyl-tRNA synthetases (aaRSs) are well studied for their role in binding and charging tRNAs with cognate amino acids. Recent RNA interactome studies had suggested that...

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Cellular labeling of endogenous retrovirus replication (CLEVR) reveals de novo insertions of the gypsy retrotransposable element in cell culture and in both neurons and glial cells of aging fruit flies

by Yung-Heng Chang, Richard M. Keegan, Lisa Prazak, Josh Dubnau Evidence is rapidly mounting that transposable element (TE) expression and replication may impact biology more widely than previously thought. This...

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Simu-dependent clearance of dying cells regulates macrophage function and inflammation resolution

by Hannah Grace Roddie, Emma Louise Armitage, Jonathon Alexis Coates, Simon Andrew Johnston, Iwan Robert Evans Macrophages encounter and clear apoptotic cells during normal development and homeostasis, including at numerous...

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High-resolution mapping reveals that microniches in the gastric glands control <i>Helicobacter pylori</i> colonization of the stomach

by Connie Fung, Shumin Tan, Mifuyu Nakajima, Emma C. Skoog, Luis Fernando Camarillo-Guerrero, Jessica A. Klein, Trevor D. Lawley, Jay V. Solnick, Tadashi Fukami, Manuel R. Amieva Lifelong infection of...

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Amot and Yap1 regulate neuronal dendritic tree complexity and locomotor coordination in mice

by Katarzyna O. Rojek, Joanna Krzemień, Hubert Doleżyczek, Paweł M. Boguszewski, Leszek Kaczmarek, Witold Konopka, Marcin Rylski, Jacek Jaworski, Lars Holmgren, Tomasz J. Prószyński The angiomotin (Amot)–Yes-associated protein 1 (Yap1)...

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Dhh1 promotes autophagy-related protein translation during nitrogen starvation

by Xu Liu, Zhiyuan Yao, Meiyan Jin, Sim Namkoong, Zhangyuan Yin, Jun Hee Lee, Daniel J. Klionsky Macroautophagy (hereafter autophagy) is a well-conserved cellular process through which cytoplasmic components are...

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Up-regulation of FOXD1 by YAP alleviates senescence and osteoarthritis

by Lina Fu, Yuqiong Hu, Moshi Song, Zunpeng Liu, Weiqi Zhang, Fa-Xing Yu, Jun Wu, Si Wang, Juan Carlos Izpisua Belmonte, Piu Chan, Jing Qu, Fuchou Tang, Guang-Hui Liu Cellular...

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CRISPR screening using an expanded toolkit of autophagy reporters identifies TMEM41B as a novel autophagy factor

by Christopher J. Shoemaker, Tina Q. Huang, Nicholas R. Weir, Nicole Polyakov, Sebastian W. Schultz, Vladimir Denic The power of forward genetics in yeast is the foundation on which the...

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HSP-4/BiP expression in secretory cells is regulated by a developmental program and not by the unfolded protein response

by Ji Zha, Mingjie Ying, Jasmine Alexander-Floyd, Tali Gidalevitz Differentiation of secretory cells leads to sharp increases in protein synthesis, challenging endoplasmic reticulum (ER) proteostasis. Anticipatory activation of the unfolded...

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Feather arrays are patterned by interacting signalling and cell density waves

[ad_1] by William K. W. Ho, Lucy Freem, Debiao Zhao, Kevin J. Painter, Thomas E. Woolley, Eamonn A. Gaffney, Michael J. McGrew, Athanasia Tzika, Michel C. Milinkovitch, Pascal Schneider, Armin...

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A single pair of leucokinin neurons are modulated by feeding state and regulate sleep–metabolism interactions

[ad_1] by Maria E. Yurgel, Priyanka Kakad, Meet Zandawala, Dick R. Nässel, Tanja A. Godenschwege, Alex C. Keene Dysregulation of sleep and feeding has widespread health consequences. Despite extensive epidemiological...

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Developmental regulation of regenerative potential in <i>Drosophila</i> by ecdysone through a bistable loop of ZBTB transcription factors

[ad_1] by Karine Narbonne-Reveau, Cédric Maurange In many organisms, the regenerative capacity of tissues progressively decreases as development progresses. However, the developmental mechanisms that restrict regenerative potential remain unclear. In...

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The Cdk8/19-cyclin C transcription regulator functions in genome replication through metazoan Sld7

[ad_1] by Kerstin Köhler, Luis Sanchez-Pulido, Verena Höfer, Anika Marko, Chris P. Ponting, Ambrosius P. Snijders, Regina Feederle, Aloys Schepers, Dominik Boos Accurate genome duplication underlies genetic homeostasis. Metazoan Mdm2...

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Avoidance response to CO<sub>2</sub> in the lateral horn

[ad_1] by Nélia Varela, Miguel Gaspar, Sophie Dias, Maria Luísa Vasconcelos In flies, the olfactory information is carried from the first relay in the brain, the antennal lobe, to the...

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MEKK3 coordinates with FBW7 to regulate WDR62 stability and neurogenesis

[ad_1] by Dan Xu, Minghui Yao, Yaqing Wang, Ling Yuan, Joerg D. Hoeck, Jingwen Yu, Liang Liu, Yvonne Y. C. Yeap, Weiya Zhang, Feng Zhang, Yinghang Feng, Tiantian Ma, Yujie...

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EGFR signaling coordinates patterning with cell survival during <i>Drosophila</i> epidermal development

[ad_1] by Samuel H. Crossman, Sebastian J. Streichan, Jean-Paul Vincent Extensive apoptosis is often seen in patterning mutants, suggesting that tissues can detect and eliminate potentially harmful mis-specified cells. Here,...

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