Tag: glutamate

Biology

Bacterially produced metabolites protect <i>C</i>. <i>elegans</i> neurons from degeneration

Newsemia
by Arles Urrutia, Víctor A. García-Angulo, Andrés Fuentes, Mauricio Caneo, Marcela Legüe, Sebastián Urquiza, Scarlett E. Delgado, Juan Ugalde, Paula Burdisso, Andrea Calixto Caenorhabditis elegans...
Gastroenterology

P152 EVALUATING THE EFFICACY OF GLUTAMATE CARBOXYPEPTIDASE II (GCPII) INHIBITORS IN “WILD-TYPE” MICE: LESSONS LEARNED FROM THE DEDICATOR OF CYTOKINESIS 2 MUTANT MOUSE

Newsemia
Glutamate carboxypeptidase II (GCPII) is highly upregulated in human IBD and is a therapeutic target under active investigation by our laboratory. We recently published that...
Cardiology

NCX and EAAT transporters in ischemia: At the crossroad between glutamate metabolism and cell survival.

Newsemia
Related Articles NCX and EAAT transporters in ischemia: At the crossroad between glutamate metabolism and cell survival. Cell Calcium. 2020 Jan 13;86:102160 Authors: Piccirillo S,...
Biology

The deubiquitinase USP6 affects memory and synaptic plasticity through modulating NMDA receptor stability

Newsemia
by Fanwei Zeng, Xuehai Ma, Lin Zhu, Qiang Xu, Yuzhe Zeng, Yue Gao, Guilin Li, Tiantian Guo, Haibin Zhang, Xiaoyan Tang, Ziqiang Wang, Zesen Ye,...
Cardiology

Ischemic Neuroprotectant PKCε Restores Mitochondrial Glutamate Oxaloacetate Transaminase in the Neuronal NADH Shuttle after Ischemic Injury.

Newsemia
Related Articles Ischemic Neuroprotectant PKCε Restores Mitochondrial Glutamate Oxaloacetate Transaminase in the Neuronal NADH Shuttle after Ischemic Injury. Transl Stroke Res. 2019 Aug 31;: Authors:...
Latest News

Glutamate Imaging Reveals Multiple Sites of Stochastic Release in the CA3 Giant Mossy Fiber Boutons

Newsemia
Rama, S; Jensen, TP; Rusakov, DA; (2019) Glutamate Imaging Reveals Multiple Sites of Stochastic Release in the CA3 Giant Mossy Fiber Boutons. Frontiers in Cellular...
Biology

NGL-3 in the regulation of brain development, Akt/GSK3b signaling, long-term depression, and locomotive and cognitive behaviors

Newsemia
by Hyejin Lee, Wangyong Shin, Kyungdeok Kim, Suho Lee, Eun-Jae Lee, Jihye Kim, Hanseul Kweon, Eunee Lee, Haram Park, Muwon Kang, Esther Yang, Hyun Kim,...
Biology

Fast calcium transients in dendritic spines driven by extreme statistics

Newsemia
by Kanishka Basnayake, David Mazaud, Alexis Bemelmans, Nathalie Rouach, Eduard Korkotian, David Holcman Fast calcium transients (<10 ms) remain difficult to analyse in cellular microdomains,...
Biology

Structures suggest a mechanism for energy coupling by a family of organic anion transporters

Newsemia
by Jonathan B. Leano, Samir Batarni, Jacob Eriksen, Narinobu Juge, John E. Pak, Tomomi Kimura-Someya, Yaneth Robles-Colmenares, Yoshinori Moriyama, Robert M. Stroud, Robert H. Edwards...
Latest News

Multiplex imaging relates quantal glutamate release to presynaptic Ca2+ homeostasis at multiple synapses in situ

Newsemia
Jensen, TP; Zheng, K; Cole, N; Marvin, JS; Looger, LL; Rusakov, DA; (2019) Multiplex imaging relates quantal glutamate release to presynaptic Ca2+ homeostasis at multiple...
Neurology

An enzyme-based electrochemical biosensor probe with sensitivity to detect astrocytic versus glioma uptake of glutamate in real time in vitro.

Newsemia
Related Articles An enzyme-based electrochemical biosensor probe with sensitivity to detect astrocytic versus glioma uptake of glutamate in real time in vitro. Biosens Bioelectron. 2018...
AI/ML

Corticostriatal network dysfunction in Huntington's disease: Deficits in neural processing, glutamate transport, and ascorbate release.

Newsemia
Related Articles Corticostriatal network dysfunction in Huntington’s disease: Deficits in neural processing, glutamate transport, and ascorbate release. CNS Neurosci Ther. 2018 04;24(4):281-291 Authors: Rebec GV...
Biology

The C9ORF72 Gene, Implicated in Amyotrophic Lateral Sclerosis and Frontotemporal Dementia, Encodes a Protein That Functions in Control of Endothelin and Glutamate Signaling [Research Article]

Newsemia
A GGGGCC repeat expansion in the C9ORF72 (C9) gene is the most common known cause of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia. Several mechanisms...
Neurology

WITHDRAWN: Therapeutic potential of metabotropic glutamate receptor 4-positive allosteric modulator TAS-4 in rodent models of movement disorders

Newsemia
This article has been withdrawn at the request of the author(s) and/or editor. The Publisher apologizes for any inconvenience this may cause.The full Elsevier Policy...
Pharma / Biotech

Effects of Modafinil on Clonic Seizure Threshold Induced by Pentylenetetrazole in Mice: Involvement of Glutamate, Nitric oxide, GABA, and Serotonin Pathways.

Newsemia
Related Articles Effects of Modafinil on Clonic Seizure Threshold Induced by Pentylenetetrazole in Mice: Involvement of Glutamate, Nitric oxide, GABA, and Serotonin Pathways. Neurochem Res....

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