gene expression

Decoding How Brain Circuits Control Behavior

neurosciencestuff: Janelia and Allen Institute scientists team up, combining genetic analyses, anatomical maps, and detailed studies of neuronal activity to reveal brain cells’ roles in controlling movement. (Image caption: Inside the...

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Human visual cortex is organized along two genetically opposed hierarchical gradients with unique developmental and evolutionary origins

by Jesse Gomez, Zonglei Zhen, Kevin S. Weiner Human visual cortex is organized with striking consistency across individuals. While recent findings demonstrate an unexpected coupling between functional and cytoarchitectonic regions...

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Dissecting the transcriptome landscape of the human fetal neural retina and retinal pigment epithelium by single-cell RNA-seq analysis

by Yuqiong Hu, Xiaoye Wang, Boqiang Hu, Yunuo Mao, Yidong Chen, Liying Yan, Jun Yong, Ji Dong, Yuan Wei, Wei Wang, Lu Wen, Jie Qiao, Fuchou Tang The developmental pathway...

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Targeted genetic screening in mice through haploid embryonic stem cells identifies critical genes in bone development

by Meizhu Bai, Yujiao Han, Yuxuan Wu, Jiaoyang Liao, Lin Li, Lijun Wang, Qing Li, Wenhui Xing, Luonan Chen, Weiguo Zou, Jinsong Li Mutagenic screening is powerful for identifying key...

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Researchers find a way to divide patients with ulcerative colitis into groups

Researchers at Karolinska Institutet in Sweden have found a way of using gene expression conserved across species to divide patients with the inflammatory bowel disease ulcerative colitis into two distinct...

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Cells in humans are affected by thirdhand smoke, study shows

Thirdhand smoke can damage epithelial cells in the respiratory system by stressing cells and causing them to fight for survival, a research team led by scientists at the University of...

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Scientists investigate genomic pillars behind transition from healthy hearts to heart failure

Scientists investigating heart failure have been limited to studying diseased heart tissue in the lab -- understandably, as people don't tend to pluck out a healthy heart for the sake...

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DPPA2/4 and SUMO E3 ligase PIAS4 opposingly regulate zygotic transcriptional program

by Yao-Long Yan, Chao Zhang, Jing Hao, Xue-Lian Wang, Jia Ming, Li Mi, Jie Na, Xinli Hu, Yangming Wang The molecular mechanism controlling the zygotic genome activation (ZGA) in mammals...

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AMPK regulates germline stem cell quiescence and integrity through an endogenous small RNA pathway

by Pratik Kadekar, Richard Roy During suboptimal growth conditions, Caenorhabditis elegans larvae undergo a global developmental arrest called “dauer.” During this stage, the germline stem cells (GSCs) become quiescent in...

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Study uncovers pigment cells that change their identity during normal development

A new study by researchers at the University of Virginia and other institutions has discovered a type of pigment cell in zebrafish that can transform after development into another cell...

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Gut bacteria linked to metabolic changes and autism in new study

Researchers have made an important discovery that may explain how gut bacteria could contribute to autism-like behaviors. Source link

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New fluorescent probe specifically labels microglia cells

Part of the immune system in the brain is made up of so-called microglia cells. Korean and Singaporean researchers have now developed a fluorescent probe that specifically labels this type...

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'Eye-in-a-dish' model helps scientists to uncover 'surprising' AMD gene variant

Researchers have discovered a new genetic variant responsible for blood vessel dysregulation in the development of age-related macular degeneration (AMD). Source link

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Researchers discover new function of ribosomes in human cells

Researchers from the Stowers Institute for Medical Research have discovered a new function of ribosomes in human cells that may show the protein-making particle's role in destroying healthy mRNAs, the...

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Foxp1 is critical for the maintenance of regulatory T-cell homeostasis and suppressive function

by Jiazi Ren, Lei Han, Jinyi Tang, Yuanhua Liu, Xiaoxue Deng, Qiuyue Liu, Pei Hao, Xiaoming Feng, Bin Li, Hui Hu, Haikun Wang Regulatory T (Treg) cells play central roles...

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Research sheds new light on the function of frequently mutated cancer protein

New research from The Wistar Institute sheds light on the function of the ARID1A protein, encoded by a gene that is among the most frequently mutated across human cancers. Source...

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Chemosensory sensilla of the <i>Drosophila</i> wing express a candidate ionotropic pheromone receptor

by Zhe He, Yichen Luo, Xueying Shang, Jennifer S. Sun, John R. Carlson The Drosophila wing was proposed to be a taste organ more than 35 years ago, but there...

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Inhibition of protein may prevent spread of castration-resistant prostate cancer

Researchers at Boston University School of Medicine have discovered that blocking a specific protein, may be a promising strategy to prevent the spread of castration-resistant prostate cancer. Source link

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Big data helps determine better research models to fight the spread of breast cancer

[ad_1] Scientists are using a lot of genomic data to identify medical issues sooner in patients, but they're also using it to assist their scientific counterparts in researching diseases better....

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Fat body–specific vitellogenin expression regulates host-seeking behaviour in the mosquito <i>Aedes albopictus</i>

by Jessica Dittmer, Ayad Alafndi, Paolo Gabrieli The high vector competence of mosquitoes is intrinsically linked to their reproductive strategy because females need a vertebrate blood meal to develop large...

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