Research provides new insights into molecular basis of X-chromosome inactivation
Researchers at the European Molecular Biology Laboratory in Heidelberg and Institut Curie in Paris have shown that the protein SPEN plays a crucial role in...
Tag : gene expression
Cannabis exposure during pregnancy has measurable impact on placental and fetal growth
A new study from researchers at Western University and Queen’s University definitively shows that regular exposure to THC, the main psychoactive ingredient in cannabis, during...
Yap suppresses T-cell function and infiltration in the tumor microenvironment
by Eleni Stampouloglou, Nan Cheng, Anthony Federico, Emily Slaby, Stefano Monti, Gregory L. Szeto, Xaralabos Varelas A major challenge for cancer immunotherapy is sustaining T-cell...
A new book on ovarian cancer
An opening discussion of contemporary management of this disease presents commentary on surgery and clinical trials: neoadjuvant, dose-dense, and heated intraperitoneal chemotherapy (HIPEC}, as well...
Study opens up new treatment possibilities for Wilms' tumor
As an embryo develops, its cells must learn what to do with the thousands of genes they’ve been equipped with. That’s why each cell comes...
Targeting specific nuclear transport systems may lead to possible therapeutic strategies for cancer
Although less often the focus of cancer research, recent studies have hinted at the possible importance of a type of protein known as nuclear transport...
Researchers identify novel genes associated with severity of peanut allergy
Researchers at the Icahn School of Medicine at Mount Sinai have identified novel genes associated with the severity of peanut allergy, as well as ways...
Perinatal exposure of rats to flame retardants changes the liver epigenome
Studies have shown that perinatal exposure of rats and mice to common flame retardants found in household items permanently reprograms liver metabolism, often leading later...
Photosensing and quorum sensing are integrated to control <i>Pseudomonas aeruginosa</i> collective behaviors
by Sampriti Mukherjee, Matthew Jemielita, Vasiliki Stergioula, Mikhail Tikhonov, Bonnie L. Bassler Bacteria convert changes in sensory inputs into alterations in gene expression, behavior, and...
Changes in placenta could mean males born to older mothers more prone to heart problems
A new study in rats shows that older mother rats develop poorer placentas which are in turn related to later risk of heart problems in...
Loss of adenomatous polyposis coli function renders intestinal epithelial cells resistant to the cytokine IL-22
by Yu Chen, Maud Vandereyken, Ian P. Newton, Ignacio Moraga, Inke S. Näthke, Mahima Swamy Interleukin-22 (IL-22) is a critical immune defence cytokine that maintains...
GPCRs show widespread differential mRNA expression and frequent mutation and copy number variation in solid tumors
by Krishna Sriram, Kevin Moyung, Ross Corriden, Hannah Carter, Paul A. Insel G protein-coupled receptors (GPCRs) are the most widely targeted gene family for Food...
Discovery in C. difficile biology opens new window to developing treatments for dangerous infections
A process called sporulation that helps the dangerous bacterium Clostridium difficile (C. difficile) to survive inhospitable conditions and spread is regulated by epigenetics, factors that...