gene expression

Changes in chromatin accessibility ensure robust cell cycle exit in terminally differentiated cells

by Yiqin Ma, Daniel J. McKay, Laura Buttitta During terminal differentiation, most cells exit the cell cycle and enter into a prolonged or permanent G0 in which they are refractory...

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Lab-grown brain organoids and the brains of preemie babies generate similar electrical impulses

Brain organoids — also called mini-brains — are 3D cellular models that represent aspects of the human brain in the laboratory. Brain organoids help researchers track human development, unravel the...

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Scientists create first detailed map of individual malaria parasite behavior

The first detailed map of individual malaria parasite behavior across each stage of its complicated life cycle has been created by scientists. Source link

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Evolution of intron splicing towards optimized gene expression is based on various <i>Cis</i>- and <i>Trans</i>-molecular mechanisms

by Idan Frumkin, Ido Yofe, Raz Bar-Ziv, Yonat Gurvich, Yen-Yun Lu, Yoav Voichek, Ruth Towers, Dvir Schirman, Heike Krebber, Yitzhak Pilpel Splicing expands, reshapes, and regulates the transcriptome of eukaryotic...

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Influenza A virus host range restricted by dysregulated expression of M gene segment

The host range of the influenza A virus is restricted by dysregulated expression of the M viral gene segment, according to a study published August 15 in the open-access journal...

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The <i>Candida albicans</i> biofilm gene circuit modulated at the chromatin level by a recent molecular histone innovation

by Laxmi Shanker Rai, Rima Singha, Hiram Sanchez, Tanmoy Chakraborty, Bipin Chand, Sophie Bachellier-Bassi, Shantanu Chowdhury, Christophe d’Enfert, David R. Andes, Kaustuv Sanyal Histone H3 and its variants regulate gene...

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Coordinated circadian timing through the integration of local inputs in <i>Arabidopsis thaliana</i>

by Mark Greenwood, Mirela Domijan, Peter D. Gould, Anthony J. W. Hall, James C. W. Locke Individual plant cells have a genetic circuit, the circadian clock, that times key processes...

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MDT-15/MED15 permits longevity at low temperature via enhancing lipidostasis and proteostasis

by Dongyeop Lee, Seon Woo A. An, Yoonji Jung, Yasuyo Yamaoka, Youngjae Ryu, Grace Ying Shyen Goh, Arshia Beigi, Jae-Seong Yang, Gyoo Yeol Jung, Dengke K. Ma, Chang Man Ha,...

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Rhythms in gene expression are highly disrupted in the brains of people with schizophrenia

Rhythms in gene expression in the brain are highly disrupted in people with schizophrenia, according to a new University of Pittsburgh-led study. Source link

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Tagger—A Swiss army knife for multiomics to dissect cell type–specific mechanisms of gene expression in mice

by Lech Kaczmarczyk, Vikas Bansal, Ashish Rajput, Raza-ur Rahman, Wiesław Krzyżak, Joachim Degen, Stefanie Poll, Martin Fuhrmann, Stefan Bonn, Walker Scot Jackson A deep understanding of how regulation of the...

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New computational method reveals genetic patterns in massive jumble of cells

Scientists have devised a new computational method that reveals genetic patterns in the massive jumble of individual cells in the body. Source link

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Ancient RNA from Late Pleistocene permafrost and historical canids shows tissue-specific transcriptome survival

by Oliver Smith, Glenn Dunshea, Mikkel-Holger S. Sinding, Sergey Fedorov, Mietje Germonpre, Hervé Bocherens, M. T. P. Gilbert While sequencing ancient DNA (aDNA) from archaeological material is now commonplace, very...

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Active mode of excretion across digestive tissues predates the origin of excretory organs

by Carmen Andrikou, Daniel Thiel, Juan A. Ruiz-Santiesteban, Andreas Hejnol Most bilaterian animals excrete toxic metabolites through specialized organs, such as nephridia and kidneys, which share morphological and functional correspondences....

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Common feature that makes cancer cells appear bloated could be their potential weak spot

In a study using yeast cells and data from cancer cell lines, Johns Hopkins University scientists report they have found a potential weak spot among cancer cells that have extra...

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Decoding How Brain Circuits Control Behavior

neurosciencestuff: Janelia and Allen Institute scientists team up, combining genetic analyses, anatomical maps, and detailed studies of neuronal activity to reveal brain cells’ roles in controlling movement. (Image caption: Inside the...

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Human visual cortex is organized along two genetically opposed hierarchical gradients with unique developmental and evolutionary origins

by Jesse Gomez, Zonglei Zhen, Kevin S. Weiner Human visual cortex is organized with striking consistency across individuals. While recent findings demonstrate an unexpected coupling between functional and cytoarchitectonic regions...

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Dissecting the transcriptome landscape of the human fetal neural retina and retinal pigment epithelium by single-cell RNA-seq analysis

by Yuqiong Hu, Xiaoye Wang, Boqiang Hu, Yunuo Mao, Yidong Chen, Liying Yan, Jun Yong, Ji Dong, Yuan Wei, Wei Wang, Lu Wen, Jie Qiao, Fuchou Tang The developmental pathway...

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Targeted genetic screening in mice through haploid embryonic stem cells identifies critical genes in bone development

by Meizhu Bai, Yujiao Han, Yuxuan Wu, Jiaoyang Liao, Lin Li, Lijun Wang, Qing Li, Wenhui Xing, Luonan Chen, Weiguo Zou, Jinsong Li Mutagenic screening is powerful for identifying key...

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Researchers find a way to divide patients with ulcerative colitis into groups

Researchers at Karolinska Institutet in Sweden have found a way of using gene expression conserved across species to divide patients with the inflammatory bowel disease ulcerative colitis into two distinct...

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Cells in humans are affected by thirdhand smoke, study shows

Thirdhand smoke can damage epithelial cells in the respiratory system by stressing cells and causing them to fight for survival, a research team led by scientists at the University of...

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