Newsemia

• October 1, 2018
• 0
• Category:
  • Pharma / Biotech
• Tags: abdominal crampsAdverse reactions associated with levothyroxine sodium tablets therapy are primarily those of hyperthyroidism due to therapeutic overdosage [see Warnings and Precautions (5)anginaanxietyarrhythmiascardiac arrest • Respiratory: dyspnea • Gastrointestinal: diarrheaelevations in liver function tests • Dermatologic: hair lossemotional labilityexcessive sweating • Central nervous system: headachefeverflushingheart failureheat intolerancehyperactivityincreased appetiteincreased pulse and blood pressureinsomnia • Musculoskeletal: tremorsirritabilitymuscle spasm • Cardiovascular: palpitationsmuscle weaknessmyocardial infarctionnervousnessOverdosage (10)]. They include the following: • General: fatiguerash • Endocrine: decreased bone mineral density • Reproductive: menstrual irregularitiestachycardiavomitingweight loss

Updated Date: Oct 1, 2018 EST

• September 28, 2018
• 0
• Category:
  • Pharma / Biotech
• Tags: a variety of other AEsabnormal lacrimationacnealopeciaangioedema. In additionanxiety/restlessnessastheniaback/neck painBisoprolol Fumarate In clinical trials worldwidebronchitisbronchospasmchest painclaudicationcold extremitiescongestive heart failureconstipationcutaneous vasculitis. Special Senses: Visual disturbancescystitisdecreased concentration/memory. Cardiovascular: Bradycardiadecreased hearingdepressiondermatitisdiarrheadizzinessdry mouth. Musculoskeletal: Arthralgiadyspepsiadyspneadyspnea on exertion. Gastrointestinal: Gastric/epigastric/abdominal painearacheeczemaedemaexfoliative dermatitis (very rarely)flushinggastritishave been reported. While in many cases it is not known whether a causal relationship exists between bisoprolol and these AEsheadachehyperesthesiahypoesthesiahypotensionin addition to those listed aboveinsomniamalaisemuscle crampsmuscle/joint painnauseaocular pain/pressureor in postmarketing experienceorthostatic hypotensionpalpitations and other rhythm disturbancesparesthesiapeptic ulcerPeyronie’s disease (very rarely)pharyngitispolyuria. General: Fatigueprurituspsoriasispurpurarenal colicrhinitissinusitisskin irritationsleep disturbance/vivid dreamssomnolencesweatingsyncopetaste abnormalities. Metabolic: Gout. Respiratory: Asthmathey are listed to alert the physician to a possible relationship. Central Nervous System: Unsteadinesstinnitustwitching/tremor. Skin: RashURI (upper respiratory infection). Genitourinary: Decreased libido/impotencevertigovomitingweight gain

Updated Date: Sep 28, 2018 EST

• September 26, 2018
• 0
• Category:
  • Pharma / Biotech
• Tags: ALBUTEROLand difficulty in micturition. Rare cases of urticariaand drying or irritation of the oropharynx. In controlled clinical trials of adult patients conducted in the United Statesand oropharyngeal edema have been reported after the use of albuterol. In additionand palpitations. Less frequent adverse reactions are muscle crampsanginaangioedemabronchospasmcan cause adverse reactions such as hypertensioncentral nervous system stimulationchest discomfortdizzinessdrowsinessflushingheadacheinsomniairritabilitylike other sympathomimetic agentsnausearashrestlessnesstachycardiaThe adverse reactions to albuterol are similar in nature to reactions to other sympathomimetic agents. The most frequent adverse reactions to albuterol are nervousnesstremorunusual tastevertigovomitingweakness

Updated Date: Sep 26, 2018 EST

• September 26, 2018
• 0
• Category:
  • Pharma / Biotech
• Tags: Additional NSAID Adverse Experiences Reported Occasionally with NSAIDs or Etodolac Extended-Release Tablets Include Body as a whole - allergic reactionanaphylactic/anaphylactoid reactions (including shock)chillscholestatic hepatitischolestatic jaundiceconfusiondepressiondream abnormalitiesdry mouthduodenitisecchymosiseosinophiliaeructationesophagitisfeverflushinggastric/peptic ulcersgastritisglossitishematemesishemolytic anemiahepatic failurehepatitisinsomniaintestinal ulcerationjaundiceleukopenialiver necrosismelenanervousnessneutropeniapalpitationspancreatitispancytopeniaparesthesiapurpurarectal bleedingsepsis Cardiovascular system - congestive heart failuresomnolencestomatitis Hemic and lymphatic system - agranulocytosissyncopetachycardiathrombocytopenia Metabolic and nutritional - hyperglycemia in previously controlled diabetic patients Nervous system - anxietytremorsvasculitis (including necrotizing and allergic) Digestive system - anorexia

Updated Date: Sep 26, 2018 EST

• September 25, 2018
• 0
• Category:
  • Pharma / Biotech
• Tags: abdominal crampsAdverse reactions associated with levothyroxine sodium tablets therapy are primarily those of hyperthyroidism due to therapeutic overdosage [see Warnings and Precautions (5)anginaanxietyarrhythmiascardiac arrest • Respiratory: dyspnea • Gastrointestinal: diarrheaelevations in liver function tests • Dermatologic: hair lossemotional labilityexcessive sweating • Central nervous system: headachefeverflushingheart failureheat intolerancehyperactivityincreased appetiteincreased pulse and blood pressureinsomnia • Musculoskeletal: tremorsirritabilitymuscle spasm • Cardiovascular: palpitationsmuscle weaknessmyocardial infarctionnervousnessOverdosage (10)]. They include the following: • General: fatiguerash • Endocrine: decreased bone mineral density • Reproductive: menstrual irregularitiestachycardiavomitingweight loss

Updated Date: Sep 25, 2018 EST

• September 25, 2018
• 0
• Category:
  • Pharma / Biotech
• Tags: abdominal discomfortabdominal painabdominal pain lowerabdominal tenderness General disorders and administration site conditions: malaiseabnormal dreamsAdverse Reactions Observed in the Phase 2/3 Studies Most common (≥10%): constipationanorexiaanxietyarthralgiaaspartate aminotransferase increased Musculoskeletal and connective tissue disorders: myalgiaastheniachillscold sweatconfusional statecoordination abnormal Psychiatric disorders: disorientationdecreased appetitedepressiondiarrheadisturbance in attentiondizzinessdrug withdrawal syndrome Hepatobiliary disorders: cholecystitis Investigations: alanine aminotransferase increaseddry mouthdyspepsiadysuria Reproductive system and breast disorders: erectile dysfunction Respiratoryedema peripheraleuphoric moodfatiguefecalomafeeling jitteryflatulenceflushinghallucinationheadachehot flushHyperhidrosisinsomniairritabilitylethargymemory impairmentmental impairmentmental status changesmood swingsmuscle spasmsmuscular weakness Nervous system disorders: depressed level of consciousnessnauseanervousness Renal and urinary disorders: urinary retentionnight sweats Vascular disorders: hypotensionorthostatic hypotension Gastrointestinal disorders: abdominal distensionpancreatitisparesthesiapiloerectionpruritusrestlessnessrhinorrhea Skin and subcutaneous tissue disorders: rashsedation Less common (<1%): Eye disorders: vision blurredsomnolence Common (≥1% to <10%): vomitingstomach discomfortstuporthinking abnormalthoracic and mediastinal disorders: dyspneatremor

Updated Date: Sep 25, 2018 EST

• September 25, 2018
• 0
• Category:
  • Pharma / Biotech
• Tags: Adverse reactions with hydrALAZINE are usually reversible when dosage is reduced. HoweverAGRANULOCYTOSISand rarelyand tingling; dizziness; tremors; muscle cramps; psychotic reactions characterized by depressionangina pectoris. Less Frequent:Digestive: constipationanorexiaarthralgiabut there has not been enough systematic collection of data to support an estimate of their frequency. Common: Headachechillsconjunctivitis. Closeconsisting of reduction in hemoglobin and red cell countdiarrheadisorientationedema. Respiratory: dyspnea. Neurologic: peripheral neuritiseosinophiliaevidenced by paresthesiafeverflushinghepatitis. Other: nasal congestionin some cases it may be necessary to discontinue the drug. The following adverse reactions have been observedlacrimationleukopenianauseanumbnessor anxiety. Genitourinary: difficulty in urination. Hematologic: blood dyscrasiaspalpitationsparadoxical pressor responseparalytic ileus. Cardiovascular: hypotensionprurituspurpura; lymphadenopathy; splenomegaly. Hypersensitive Reactions: rashtachycardiaurticariavomiting

Updated Date: Sep 25, 2018 EST

• August 31, 2018
• 0
• Category:
  • Dermatology
• Tags: ArthroscopicArthroscopic flushing fluid;Cartilage regeneration;Hydrogel;Mesenchymal stem cellscartilageCellsCrosslinkedEncapsulatedFluidderivedflushingHydrogelmesenchymalOnesteprapidregenerationstem

Related Articles Cartilage Regeneration Using Arthroscopic Flushing Fluid-derived Mesenchymal Stem Cells Encapsulated in a One-step Rapid Cross-linked Hydrogel. Acta Biomater. 2018 Aug 27;: Authors: Li J, Huang Y, Song J,...

• August 9, 2018
• 0
• Category:
  • Neurology
• Tags: caseCHILDCongenitalEpisodicfacialflushingharlequinInfantneurologyRareReviewsyndrome

Congenital harlequin syndrome is rare dysautonomia of the face most often reported in adults and rarely in infants and children. It is a diagnosis of exclusion and a seemingly benign...

• July 20, 2018
• 0
• Category:
  • Pharma / Biotech
• Tags: 5.2 Serotonin Syndrome The development a potentially life-threatening serotonin syndrome has been reported with SNRIs and SSRIs5.2 Serotonin Syndrome The development of a potentially life-threatening serotonin syndrome has been reported with SNRIs and SSRIsagitationalone but particularly with concomitant use of other serotonergic drugs (including triptansamphetaminesand coma)and St. John’s Wort) and with drugs that impair metabolism of serotonin (in particularand/or gastrointestinal symptoms (e.g.autonomic instability (e.g.both those intended to treat psychiatric disorders and also othersbuspironedeliriumdiaphoresisdiarrhea). Patients should be monitored for the emergence of serotonin syndrome. Serotonin syndrome symptoms may include mental status changes (e.g.dizzinessfentanylflushinghallucinationshyperreflexiahyperthermiaincluding fluoxetineincoordinationlabile blood pressurelithiumMAOIsmyoclonusnauseaneuromuscular symptoms (e.g.rigidityseizuressuch as linezolid and intravenous methylene blue). Serotonin syndrome symptoms may include mental status changes (e.g.such as linezolid and intravenous methylene blue). The development of a potentially life-threatening serotonin syndrome has been reported with SNRIs and SSRIstachycardiatramadoltremortricyclic antidepressantstryptophanvomiting

Updated Date: Jul 20, 2018 EST

• July 20, 2018
• 0
• Category:
  • Pharma / Biotech
• Tags: abdominal crampsAdverse reactions associated with levothyroxine sodium tablets therapy are primarily those of hyperthyroidism due to therapeutic overdosage [see Warnings and Precautions (5)anginaanxietyarrhythmiascardiac arrest • Respiratory: dyspnea • Gastrointestinal: diarrheaelevations in liver function tests • Dermatologic: hair lossemotional labilityexcessive sweating • Central nervous system: headachefeverflushingheart failureheat intolerancehyperactivityincreased appetiteincreased pulse and blood pressureinsomnia • Musculoskeletal: tremorsirritabilitymuscle spasm • Cardiovascular: palpitationsmuscle weaknessmyocardial infarctionnervousnessOverdosage (10)]. They include the following: • General: fatiguerash • Endocrine: decreased bone mineral density • Reproductive: menstrual irregularitiestachycardiavomitingweight loss

Updated Date: Jul 20, 2018 EST

• July 18, 2018
• 0
• Category:
  • Pharma / Biotech
• Tags: acarodermatitisacneactive-controlledalanine aminotransferase increasedamenorrheaand anorgasmia Renal and Urinary Disorders: enuresisand Mediastinal Disorders: wheezingand open-label studies of RISPERDAL ® in adults and pediatric patients. Blood and Lymphatic System Disorders: anemiaanorexia Musculoskeletal and Connective Tissue Disorders: joint stiffnessaptyalism General Disorders: edema peripheralatrioventricular block Ear and Labyrinth Disorders: ear painatrioventricular block first degreeblood glucose increasedblood pressure decreasedblood prolactin increasedblunted affectbody temperature decreasedbreast enlargement Respiratorybronchitisbronchopneumoniabundle branch block leftbundle branch block rightcellulitiscerebral ischemiacerebrovascular accidentcerebrovascular disordercheilitischest discomfortchillsconfusional stateconjunctivitiscoordination abnormalcystitisdepressed level of consciousnessdiabetic comadiscomfortdisturbance in attentiondrug withdrawal syndromedry eyedysarthriadyskinesiadysphoniadysuriaear infectionedemaejaculation disorderelectrocardiogram abnormaleosinophil count increasederectile dysfunctioneye dischargeeye infectioneye rollingeye swellingeyelid edemaeyelid margin crustingface edemafecal incontinencefecalomafeeling abnormal Immune System Disorders: drug hypersensitivity Infections and Infestations: pneumoniaflushinggait disturbancegalactorrheagastritisgeneralized edemaglaucomagranulocytopeniaGynecomastiahead titubation Psychiatric Disorders: agitationhematocrit decreasedhemoglobin decreasedhyperkeratosishyperventilationhypoesthesiainfluenzainfluenza-like illnessjoint swellinglacrimation increasedlibido decreasedlip swellinglistlessnesslocalized infectionloss of consciousnessmalaisemenstrual disordermiddle insomniamovement disordermuscular weaknessmusculoskeletal chest painmyalgianasal edema Skin and Subcutaneous Tissue Disorders: erythemaneck painnervousnessneuroleptic malignant syndromeneutropenia Cardiac Disorders: sinus bradycardiaonychomycosisOther Adverse Reactions Observed During the Clinical Trial Evaluation of Risperidone The following additional adverse reactions occurred across all placebo-controlledotitis mediaotitis media chronic Investigations: body temperature increasedperipheral coldnesspharyngitisphotophobiapitting edemapneumonia aspirationpollakiuriapolydipsiaposture abnormalproductive coughprurituspulmonary congestionralesrash erythematousrash generalizedrash maculopapularrash papularrespiratory disorderrespiratory tract congestionrespiratory tract infectionretrograde ejaculationrhabdomyolysis Nervous System Disorders: balance disorderseborrheic dermatitis Vascular Disorders: hypotensionsexual dysfunctionsinus congestionsinus tachycardiaskin discolorationskin disorderskin lesionsleep disordersluggishnessspeech disordersyncopetardive dyskinesiathirstThoracictinnitus Endocrine Disorders: hyperprolactinemia Eye Disorders: ocular hyperemiatonsillitistracheobronchitistransaminases increased Metabolism and Nutrition Disorders: decreased appetitetransient ischemic attackunresponsive to stimuliurinary incontinence Reproductive System and Breast Disorders: menstruation irregularvaginal dischargeviral infectionvisual acuity reduced Gastrointestinal Disorders: dysphagiawhite blood cell count decreased

Updated Date: Jul 18, 2018 EST

• July 18, 2018
• 0
• Category:
  • Pharma / Biotech
• Tags: Adverse reactions reported coincident with the administration of methocarbamol include: Body as a whole: Anaphylactic reactionangioneurotic edemafeverflushingheadache Cardiovascular system: Bradycardiahypotensionsyncope

Updated Date: Jul 18, 2018 EST

• July 17, 2018
• 0
• Category:
  • Pharma / Biotech
• Tags: Adverse reactions reported coincident with the administration of methocarbamol include: Body as a whole : Anaphylactic reactionangioneurotic edemaconfusionconjunctivitisdiplopiadizziness or lightheadednessdrowsinessfeverflushingheadache Cardiovascular system : Bradycardiahypotensioninsomniajaundice (including cholestatic jaundice)metallic tastemild muscular incoordinationnasal congestionnausea and vomiting Hemic and lymphatic system: Leukopenia Immune system : Hypersensitivity reactions Nervous system: Amnesianystagmuspruritusrashsedationseizures (including grand mal)syncopethrombophlebitis Digestive system: DyspepsiaurticarialClosevertigo Skin and special senses : Blurred vision

Updated Date: Jul 17, 2018 EST

• July 11, 2018
• 0
• Category:
  • Pharma / Biotech
• Tags: Adverse reactions with hydrALAZINE are usually reversible when dosage is reduced. HoweverAGRANULOCYTOSISand rarelyand tingling; dizziness; tremors; muscle cramps; psychotic reactions characterized by depressionangina pectoris. Less Frequent:Digestive: constipationanorexiaarthralgiabut there has not been enough systematic collection of data to support an estimate of their frequency. Common: Headachechillsconjunctivitis. Closeconsisting of reduction in hemoglobin and red cell countdiarrheadisorientationedema. Respiratory: dyspnea. Neurologic: peripheral neuritiseosinophiliaevidenced by paresthesiafeverflushinghepatitis. Other: nasal congestionin some cases it may be necessary to discontinue the drug. The following adverse reactions have been observedlacrimationleukopenianauseanumbnessor anxiety. Genitourinary: difficulty in urination. Hematologic: blood dyscrasiaspalpitationsparadoxical pressor responseparalytic ileus. Cardiovascular: hypotensionprurituspurpura; lymphadenopathy; splenomegaly. Hypersensitive Reactions: rashtachycardiaurticariavomiting

Updated Date: Jul 11, 2018 EST

• July 11, 2018
• 0
• Category:
  • Pharma / Biotech
• Tags: agitationblurring of vision. Gastrointestinal: Dryness of the mouthCardiovascular: Palpitationchanges in libido.Closeconstipationdiarrheadizzinessdysuriaelevated blood pressure. Central Nervous System: Overstimulationflushingheadacheinsomnianauseapsychotic staterestlessnessstomach pain. Genitourinary: Urinary frequencysweatingtachycardiatremor

Updated Date: Jul 11, 2018 EST